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[1] K. Dhingra and G.N. Hortobagyi: “Critical evaluation of prognostic factors”, Sem. Oncol., Vol. 23, (1996), pp. 436–445. [2] J. Sjostrom, C. Blomqvist, P. Heikkila, K.V. Bogulawski, A. Raiseanen-Sokolowski, N.O. Bengtsson, I. Mjaaland, P. Malmstron, B. Ostenstadt, J. Berg, E. Wist, V. Valvere and E. Saksela: “Predictive value of p53, mdm-2, p21, and mib-1 for chemotherapy response in advanced breast cancer”, Clin. Cancer Res., Vol. 6(8), (2000), pp. 3103–3110. [3] K.L. Cheung, C.R. Graves and J.F. Robertson: “Tumour marker measurements in the diagnosis and

Introduction The majority of studies reporting on the incidence of breast cancer during pregnancy include also cases of pregnancy-associated breast cancer (PABC). This term implies breast cancer diagnosed during pregnancy and 12 months postpartum. A swedish population-based cohort study analyzing cancer and multi-generation register estimates the incidence of PABC at 28/100,000 live births [ 1 ]. Most cases were diagnosed after delivery. Breast cancer and melanoma were the two most common malignancies during pregnancy and the postpartum period [ 2 ]. Fortunately

needle biopsie: to excise or not excise? AM J Surg Pathol 2002; 26 : 185-197. Silva OE, Zurrida S. Breast Cancer: A Practical Guide. Elsevier 2000; 11-87. Frank TS, Manley SA, Olopade OI, Cummings S, Garber JE, Bernhardt B, Antman K, Russo D, Wood ME, Mullineau L, Isaacs C, Peshkin B, Buys S, Venne V, Rowley PT, Loader S, Offit K, Robson M, Hampel H, Brener D, Winer EP, Clark S, Weber B, Strong LC, Thomas Thomas A, et al. Seqence analysis of BRCA1 and BRCA2: correlation of mutations with family history and ovarian cancer risk. J Clin Oncol 1997; 16 : 2417

References 1. Peto R. Mortality from breast cancer in UK has decreased suddenly. Bmj. 1998 Aug 15;317(7156):476-7 2. Peto R, Boreham J, Clarke M, Davies C, Beral V. UK and USA breast cancer deaths down 25% in year 2000 at ages 20-69 years. Lancet. 2000 May 20;355(9217):1822 3. Rouanet G., Gardi S., Larra F.: Le cancer du sein ches de Cammes âgccs de moins de 35 ans. Rev. fr. Gynecol obstet 1993 Feb;88(2):89-90. 4. Sondik EJ. Breast cancer trends. Incidence, mortality, and survival. Cancer. 1994 Aug 1;74(3 Suppl):995-9. 5. Foekens JA, Atkins D, Zhang Y, Sweep FC

References Baljet, B. 2000. The painted Amsterdam anatomy lessons: anatomy performances in dissecting rooms? Ann. Anat. 182: 3-11. Batistatou, A., Charalabopoulos, K. A. 2005. The art of science: Transitional cell carcinoma of the bladder and Golconda. Med. Hypotheses 65: 970-971. Baum, M. 2003. La Fornarina: breast cancer or not? Lancet 361: 1129. Belkin, K. L., Healy, F. Martin, G. 2004. Painting and sculpture. In: K. L. Belkin, F. Healy (eds), A house of art. Rubens as collector. Rubenshuis & Rubenianum, Antwerpen, pp 88-259. Bonjer, H. J., Bruining, H. A

Horm Mol Biol Clin Invest 2012;9(2):119–126 © 2012 by Walter de Gruyter • Berlin • Boston. DOI 10.1515/hmbci-2012-0001 Aromatase inhibitors and breast cancer Saranya Chumsri 1 and Angela Brodie 2, * 1 Department of Medicine , University of Maryland School of Medicine, and the Greenebaum Cancer Center, Baltimore, MD 21201 , USA 2 Department of Pharmacology and Experimental Therapeutics , University of Maryland School of Medicine, and the Greenebaum Cancer Center, Baltimore, MD 21201 , USA Abstract Breast cancer is the most prevalent cancer