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References 1. Third European Evidence-based Consensus on Diagnosis and Management of Ulcerative Colitis. Part 1: Definitions, Diagnosis, Extra-intestinal Manifestations, Pregnancy, Cancer Surveillance, Surgery, and Ileo-anal Pouch Disorders, Journal of Crohn’s and Colitis, Volume 11, Issue 6, 1 June 2017, Pages 649–670) 2. Second European evidence-based consensus on the diagnosis and management of ulcerative colitis Part 2: Current management, Journal of Crohn’s and Colitis (2012) 6, 991–1030 3. Christian Maaser at all, ECCO-ESGAR Guideline for Diagnostic

23Plata-Nazar K. et al.: Neopterin in Children with Ulcerative Colitis Pteridines/Vol. 19/No. 1 Correspondence to: Katarzyna Plata-Nazar MD, PhD, Chair and Department of Pediatrics, Pediatric Gastroenterology, Hepatology and Nutrition, Medical University of Gdansk, Poland. Ul. Nowe Ogrody 1-6, 80-803 Gdask, Poland, phone/fax ++48 58 302 25 91, knazar@amg.gda.pl Pteridines Vol. 19, 2008, pp. 23 - 27 Serum Neopterin Concentration in Children with Ulcerative Colitis Katarzyna Plata-Nazar, Grazyna Luczak, Barbara Kaminska, Marta Bogotko-Szarszewska, Joanna Renke

Introduction Ulcerative colitis (UC) is a subcategory of inflammatory bowel disease (IBD) characterized by continuous inflammation in the intestinal mucosa or lamina propria. The disease can progress from mild to severe with many features, e.g. abdominal pain, diarrhea, fatigue, weight loss, rectal bleeding, and bloody stool. In severe cases, blood and mucus in stool, fistula, fissure hemorrhoids, and anemia are observed [ 1] . The incidence of the disease is increasing steadily in industrialized countries, while developing countries have had a rapidly increased

Introduction Ulcerative colitis (UC), a subtype of inflammatory bowel disease (IBD), is a chronic inflammatory condition of the mucosa of the large intestine. The epidemiological trend suggests that its incidence is rising in the developing world and has reached a plateau in the developed world [ 1 ], [ 2 ]. Its prevalence rate varies from 37.5 to 248.6/100,000 in North America and 4.9 to 505/100,000 in Europe, with an annual incidence rate ranging from 0 to 19.2/100,000 in North America and 0.6 to 24.3/100,000 in Europe [3] . In India, the prevalence rate is 44

.5 μmol/ml or 0.25 mg/ml)) include some beers, ciders, and wines. The sulfate content of beer is discussed with particular relation to epidemiological observations which link ingestion of beer with colorectal cancer [ 8 ]. Inflammatory bowel disease (IBD) including ulcerative colitis (UC) or Crohn’s disease is characterized by chronic inflammation of the large intestine in genetically susceptible individuals of unknown etiology [ 9 , 10 ]. One of the hypotheses is that UC is caused by the toxic molecule of H 2 S. In persons with ankylosing spondylitis and, with

: Neuberger J ed. Primary Biliary Cirrhosis. Eastbourne: West End Studios; 2000. p. 41-52. 5. Mackay I-R. Historical reflections on autoimmune hepatitis. World J. Gastroenterol. 2008 Jun 7;14(21):3292-300. 6. Turner D, Otley AR, Mack D, Hyams J, de Bruijne J, Uusoue K, et al. Development, Validation, and Evaluation of a Pediatric Ulcerative Colitis Activity Index: A Prospective Multicenter Study. Gastroenterology. 2007 Aug;133(2):423-32. 7. Schroeder KW, Tremaine WJ, Ilstrup DM. Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A

Clin Chem Lab Med 2009;47(9):1085–1090 2009 by Walter de Gruyter • Berlin • New York. DOI 10.1515/CCLM.2009.248 2009/221 Article in press - uncorrected proof Clinical relevance of circulating midkine in ulcerative colitis Malgorzata Krzystek-Korpacka1,*, Katarzyna Neubauer2 and Malgorzata Matusiewicz1 1 Department of Medical Biochemistry, Wroclaw Medical University, Wroclaw, Poland 2 Department of Gastroenterology and Hepatology, Wroclaw Medical University, Wroclaw, Poland Abstract Background: Non-invasive biochemical markers are needed to support the diagnosis

[1] Torres J, Billioud V, Sachar DB, et al. Ulcerative colitis as a progressive disease: The forgotten evidence. Inflamm Bowel Dis 2012; 18: 1356–1363 http://dx.doi.org/10.1002/ibd.22839 [2] Rellecke P, Strauer BE. Chronic inflammatory bowel disease and cardiovascular complications. Med Klin (Munich) 2006; 101Suppl 1): 56–60 [3] McEniery CM, Wilkinson IB. Large artery stiffness and inflammation. J Hum Hypertens 2005; 19: 507–509 http://dx.doi.org/10.1038/sj.jhh.1001814 [4] Nemes A, Takács R, Gavallér H, et al. Correlations between Arteriograph-derived pulse wave

Colitis ulcerosa Definition: Bei der Colitis ulcerosa besteht eine chronische, meist in Schü- ben verlaufende Entzündung der Rektumschleimhaut, die sich vom Dick- darm kontinuierlich nach proximal ausdehnen kann. Die Prävalenz beträgt 50/100.000 bei einer Inzidenz von 3/100.000/Jahr. Die Manifestation er- folgt in der 2. und 3. Lebensdekade. Mit der Menstruation können neue Schübe ausgelöst werden. Wahrscheinlich ist die Colitis ulcerosa eine Au- toimmunerkrankung mit einer genetischen Disposition (3). OC-Anwendung: OC sind relativ kontraindiziert. Die Colitis

8 2 C l a u d i c a t i o i n t e r m i t t e n s Diagnostik: Röntgen: Aussage: aszendierende Preß-Phlebographie (s. Bein-Phlebographie). beantwortet Fragen nach Ursache der Ch.-v. I., nach ihrem Ausmaß, nach Funktion der venösen Abflüsse, nach Kollateralen, nach Prognose und Therapiemöglichkeiten. Claudicatio intermittens siehe Durchblutungsstörungen Colica mucosa (syn. Colitis mucosa) ätiolog. noch nicht eindeutig geklärt: Sekretionsstörungen, bakterielle, allergische und psy- chische Ursachen? Weibliches Geschlecht bevorzugt befallen. Klinik