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Synthesis of a New Cyclic Peptide, Pseudostellarin G Boja Poojarya, K. Harish Kumar, and S. L. Belagalib a Department of Post-Graduate Studies and Research in Chemistry, Mangalore University, Mangalagangotri-574 199, Mangalore, India b Department of Environmental Sciences, University of Mysore, Mysore-575 006, India Reprint requests to Dr. B. Poojary. Fax: 91 824 2287 367. E-mail:bojapoojary@yahoo.com Z. Naturforsch. 59b, 817 – 820 (2004); received January 10, 2004 A new biologically active cyclic peptide, Pseudostellarin G was synthesized and the structure was

Synthesis, Characterization and Biological Evaluation of Cyclic Peptides: Viscumamide, Yunnanin A and Evolidine Boja Poojarya and S. L. Belagalib a Department of Post-Graduate Studies and Research in Chemistry, Mangalore University, Mangalagangotri-574 199, Mangalore, India b Department of Environmental Sciences, University of Mysore, Mysore-575 006, India Reprint requests to Dr. B. Poojary. Fax: 91 824 2287 367. E-mail: bojapoojary@yahoo.com Z. Naturforsch. 60b, 1313 – 1320 (2005); received May 26, 2004 Three biologically active cyclic peptides, viscumamide

and distribution of Microcystis (Cyanobacteria) oligopeptide chemotypes from natural communities studied by single-colony mass spectrometry. Microbiol 2004; 150: 1785-96. Sedmak B, Carmeli S, Eleršek T. >>Non-toxic<< cyclic peptides induce lysis of cyanobacteria - an effective cell population density control mechanism in cyanobacterial blooms. Microb Ecol 2007; DOI 10.1007/s00248-007-9336-9. Starmach K. Cyanophyta - sinice, Glaucophyta - glaucofiti. Flora słodkow. Polski 2. Warszawa: P.W.N.; 1966: 807 pp. Anagnostidis K, Komarek J. Modern approach to the

Biol. Chem., Vol. 389, pp. 1339–1346, October 2008 • Copyright by Walter de Gruyter • Berlin • New York. DOI 10.1515/BC.2008.153 2008/177 Article in press - uncorrected proof Cytotoxic and peptidase inhibitory activities of selected non-hepatotoxic cyclic peptides from cyanobacteria Anja Bubik1, Bojan Sedmak1,*, Marko Novinec2, Brigita Lenarčič2,3 and Tamara T. Lah1,3 1 Department of Genetic Toxicology and Cancer Biology, National Institute of Biology, Večna pot 111, POB 141, SI-1001 Ljubljana, Slovenia 2 Department of Biochemistry, Molecular and Structural

RECENT DEVELOPMENTS IN THE CHEMISTRY AND BIOLOGY OF CYCLIC PEPTIDES Yuri Ovchinnikov, Gunar Chipens* and Vadim Ivanov Shemyakin Institute of Bioorganic Chemistry, USSR Academy of Sciences, 117988 Moscow, USSR *Institute of Organic Synthesis, Latvian Academy of Sciences, Riga, USSR Cyclopeptides comprise a large group of compounds isolated from natural sources or obtained by chemical synthesis. There are many reasons due to which cyclic peptides over a number of decades remain a popular object of study. All cyclic peptides (except cyclic disulfides) are

HOMO- AND HETERONUCLEAR TWO-DIMENSIONAL. NMR SPECTROSCOPY OF 1 ) CYCLIC PEPTIDES ' Horst Kessler, Regina Schuck Institut für Organische Chemie der Universität, Niederurseier Hang, D-6000 Frankfurt, Germany The potential of two-dimensional NMR methods (2D NMR) for conformational studies of peptides and small proteins is now well established (2). But all applications in this field are restricted to homonuclear techniques (Jeener, SECSY, NOESY). We will report here three examples where different hetero- nuclear and homonuclear techniques are used to analyze

Pure & Appl. Chem., Vol. 70, No. 2, pp. 391-396, 1998. Printed in Great Britain. (0 1998 IUPAC Studies directed on the synthesis of Vancomycin and related cyclic peptides A V Rama Rao A V Rama Rao Research Foundation AVRA House, Habshiguda, Hyderabad 500 007, India In recent years considerable interest has been devoted to the vancomycin group of antibiotics, which include related glycopeptides of biological importance. The most important among them is vancomycin (l), the first biologically active antibiotic reported in 1956, and was introduced into

Cameroon. Moringa stenopetala is a smooth-barked deciduous tropical plant distributed in eastern and western Africa. A report on the various uses of M. stenopetala has shown that it is a multipurpose plant of wide use for the community [12]. It has been reported to exhibit antimicrobial activity [13], while its seeds are used as purifiers of muddy and turbid water in Africa [14, 15]. In the present study, a new γ-aminobutyric acid (GABA)-containing cyclic peptide ( 1 ) together with a known congener ( 2 ), were isolated. Details on the isolation and structure

INTERNAL MOBILITY OF A CYCLIC PEPTIDE. A ROTATING FRAME RELAXATION STUDY K.D. Kopple* and Y.-S. Wang Department of Chemistry, Illinois Institute of Technology Chicago, Illinois 60616, U.S.A. *Present address: L-940, Smith Kline & French Laboratories, P.O. Box 7929, Philadelphia, Pennsylvania 19101, U.S.A. When conformation interchanges occur near 105 s. - 1, the nuclear magnetic resonance spectrum of a peptide will still be a narrow line average over the exchanging species. In this rate range, however, conformational fluctuations can contribute

Pure & Appl. Chem., Vol. 68, No. 3, pp. 565-568. 1996. Printed in Great Britain. 0 1996 IUPAC Studies directed towards the development of cyclic peptide-based analogs of macrolide immunosuppressants+ Tushar K Chakraborty Indian Insti tute of Chemica l Technology, Hyderabad 500 007, India Abstract : A simple s t r a t egy for t h e facile synthesis of cyc l ic rapamycin- peptide hybrids is developed and t h e affinit ies of t hese synthe t ic hybrids fo r FKBPl2 a r e evaluated. The results prompted to undertake a syste- m a t i c study on t