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A. Thyroid: biological actions of ‘nonclassical’ thyroid hormones. J Endocrinol. 2014;221(2):R1-12. DOI: 10.1530/JOE-13-0573 8. Gnidehou S, Caillou B, Talbot M, Ohayon R, Kaniewski J, Noël-Hudson MS, et al. Iodotyrosine dehalogenase 1 (DEHAL1) is a transmembrane protein involved in the recycling of iodide close to the thyroglobulin iodination site. FASEB J. 2004;18(13):1574-6. DOI: 10.1096/fj.04-2023fje 9. Maia AL, Goemann IM, Meyer EL, Wajner SM. Deiodinases: the balance of thyroid hormone: type 1 iodothyronine deiodinase in human physiology and disease. J

© Freund Publishing House Ltd., London Journal of Pediatric Endocrinology & Metabolism, 20, 95-98 (2007) Ontogenetic Development of the Iodothyronine Deiodinases Serge Van der Geyten, Carla Verhoelst, Eduard R. Kühn and Veerle M. Darras Laboratory of Comparative Endocrinology, Zoological Institute, K.U.Leuven, Leuven, Belgium Thyroid hormones (TH) are essential for normal embryonic development in all vertebrate species. In humans, this is most evident in the central nervous system where both TH deficiency as well as TH excess result in abnormal brain

propylthiouracil, Br J Clin Pharmacol 1983, 16 549-552. 39. Feng Q, Gao Y, Li H: The effects of propylthiouracil on the fetal thyroid and serum concentration in pregnant women. Zhong Nei Ke Za Zhi 1996, 35 295-8. 40. Forhead AJ, Curtis K, Kaptein E, Visser TJ, Fowden AL: Developmental control of iodothyronine deiodinases by cortisol in the ovine fetus and placenta near term. Endocrinology 2006, 147(12)5988-94. 41. Kuiper GG, Kester MH, Peeters RP, Visser, TJ: Biochemical mechanisms of thyroid hormone deiodination. Thyroid 2005, 15(8):787-798. 42. Koopdonk-Kool JM, de Vijlder JJ

predisposition and severity and accel- erates recovery in a variety of pathologies. Pre-supple- mentation Se levels and sex represent important determinants of these Se-dependent health effects. Accordingly, we previously reported on sexually dimor- phic expression patterns of Se-dependent glutathione peroxidase 1, type I deiodinase, and selenoprotein P in young mice. In the present study we investigated wheth- er these differences vary with age. The strong sexual dimorphic expression of hepatic type I deiodinase that was observed in young mice vanished both at the mRNA and

consumptive hypothyroidism caused by high activity of type 3 iodothyronine deiodinase enzyme (D3) was established. He was started on oral L-thyroxine at 15 μg/kg/day. Because of massive liver enlargement due to multiple haemangiomatous nodules, oral methylprednisolone (2.5 mg/kg/day divided into two doses per day) was initiated, and he was switched to oral propranolol (2 mg/kg/day divided into two doses a day). The progress of hepatic haemangioma in this case was discussed elsewhere recently [ 11 ]. On hospital day 7, repeat TFTs demonstrated an elevated TSH level of 278 mU

could be extracted from thyroidal colloid by incubation with 0.5% sodium dodecyl sulfate indicating that this enzyme is (i) secreted into the follicular lumen and (ii) loosely attached to the colloidal thyroglobulin. These findings are consistent with a role of selenoproteins in the protection of the thyroid from possible damage by H2O2. Particularly, GPx3 might use excess H2O2 and catalyze the polymerization of thyroglobulin to the highly cross-linked storage form present in the colloid. Keywords: deiodinase; glutathione peroxidase 1; glutathione peroxidase 3

di Milano, IRCCS Fondazione Ca ’ Granda, Ospedale Maggiore Policlinico, Milan , Italy Abstract Consumptive hypothyroidism is a rare condition related to massive infantile hemangiomas producing an excess of the thyroid-hormone-inactivating enzyme type 3 iodothy- ronine deiodinase. We report the fi rst case of consumptive hypothyroidism secondary to a large parotid hemangioma, highlighting the diffi culties in selecting an adequate thera- peutic strategy. The affected child was initially referred to our center for congenital hypothyroidism with a hyp

References 1. McKenzie RC, Arthur JR, Miller SM, Rafferty TS, Beckett GJ: Selenium and the immune system. In: Nutrition and Immune Function, CAB International, Oxford, U.K 2002, 229-250. 2. Arthur JR, Nicol F, Beckett GJ: Hepatic iodothyronine 5’ deiodinase. The role of selenium. Biochem J 1990, 272:537-540. 3. Hoffmann PR, Hoge SC, Li PA, Hoffman FV, Hashimoto AC, Berry MJ: The selenoproteome exhibits widely varying, tissue-specific dependence on selenoprotein P for selenium supply, Nucleic Acids Res 2007, 35:3963-3973. 4. Berry MJ, Banu L, Chen YY, Mandel SJ

Introduction The association of hypothyroidism and hepatic hemangioma (HH), first described by Huang et al. in 2000 (1), is now reported with increasing frequency (2). Kulungowski et al. collected a large series of HH in their register: they found that hypothyroidism was documented in 100% of patients with diffuse HH and in 21.4% of patients with multifocal HH (3). Consumptive hypothyroidism in children with HH is due to overexpression of type 3 iodothyronine-deiodinase (D3) by the vascular tumor. This enzyme transforms thyroxine and triiodothyronine by

than 15 prokaryotic seleno- proteins containing the 21st proteinogenic amino acid, selenocysteine, have been identified, partially charac- terized or cloned from several species. Many of these proteins are involved in redox reactions with seleno- cysteine acting as an essential component of the catalytic cycle. Enzyme activities have been assigned to the glutathione peroxidase family, to the thioredoxin reductases, which were recently identified as sele- noproteins, to the iodothyronine deiodinases, which metabolize thyroid hormones, and to the selenophos- phate