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length) to prevent obstruction. After surgery, rats were housed individually. They were maintained undisturbed for a week recovery period. Apparatus The elevated plus-maze (EPM) was made of wooden and consisted of two open arms, 50 × 10 cm (length per wide), and two closed arms 50 × 10 × 50 cm (length per wide per height). The two arms of each type were opposite to each other. The EPM was elevated to a height of 50 cm. A 60 W bulb 1.5 m above the apparatus illuminated the room. Procedure and Test 15 min before testing rats were injected under manual restraint. A

ABBREVIATIONS NAC - N-acetylcysteine EPM - elevated plus maze TEA - total exploratory activity ROS - reactive oxygen species REFERENCES 1. Bednarski PJ, Korpis K, Westendorf AF, Perfahl S, Grünert R. Effects of light-activated diazido-PtIV complexes on cancer cells in vitro. Philos Trans A Math Phys Eng Sci. 2013;17:371. 2. Pabla N, Dong Z. Cisplatin nephrotoxicity: mechanisms and renoprotective strategies. Kidney Int. 2008;73(9):994-1007. 3. Waseem M, Bhardwaj M, Tabassum H, Raisuddin S, Parvez S. Cisplatin hepatotoxicity mediated by mitochondrial stress. Drug

SHORT COMMUNICATION DOSE-RELATED ANXIOGENIC EFFECT OF GLYCINE IN THE ELEVATED PLUS MAZE AND IN ELECTRODERMAL ACTIVITY Nazan Dolu University of Erciyes, Faculty of Medicine, Department of Physiology, 38039 Kayseri, TURKEY ABSTRACT We investigated effect of glycine on anxiety at different doses using electrodermal activity and an elevated-plus maze. A single dose of glycine was injected intraperitoneally into three different groups of mice at 250 mg/kg, 750 mg/kg, and 1250 mg/kg. The anxiety scores with the elevated-plus maze, consisting of two open

THE EFFECTS OF SERTRALINE AND FLUOXETINE ON ANXIETY IN THE ELEVATED PLUS-MAZE TEST IN MICE Mehmet Kurt1*, Ali Cezmi Arik2 and Suleyman Qelik1 Departments of' Pharmacology and2Psychiatry, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey A B S T R A C T The aim of this study was to evaluate the acute and chronic effects of two SSRIs (sertraline and fluoxetine) on anxiety by the elevated plus-maze test. Diazepam increased the time spent in open arms significantly whereas the anxiogenic m-chlorophenylpiperazine (m- CPP) decreased the time

: Iss. 1, Article 24. DOI: 10.2202/1553-3840.1147 Anxiolytic Effect of Flowers of Salix aegyptiaca L. in Mouse Model of Anxiety Mohammed Rabbani, Seyed Ebrahim Sajjadi, and Fatimeh Rahimi Abstract The aim of the present study was to evaluate the anxiolytic effects of total extract of flowers of Salix aegyptiaca on the elevated plus-maze (EPM) model of anxiety. The extract of the flower parts of the plant was administered by i.p. and p.o. to male NMRI mice, at various doses. Oral and i.p. administration of the S. aegyptiaca significantly increased the percentage of

.2202/1553-3840.1263 Anxiolytic Activity of Canscora decussata in Albino Rats Neeraj K. Sethiya, Alok Nahata, and Vinod K. Dixit Abstract Shankhpushpi is a popular medicinal plant in the Ayurvedic system of medicine for treating mental disorders. The present study was undertaken to investigate the effects of Canscora decussata Schult. (Gentianaceae) commonly known as shankhpushpi on the central nervous system of albino rats. Ethanolic extract of the aerial parts of the plant was evaluated in the elevated plus-maze test, open field exploratory behavior and rotarod performance experiments. In

urine [ 4 ]. However, chronic exposure to aluminium leads to its accumulation in the brain in old age [ 5 ], [ 6 ]. Aluminium is a potential neurotoxin which causes learning difficulties and dementia in rats [ 7 ]. It also causes anxiety disorders in rats, as it is evident from elevated plus maze (EPM) experiments [ 8 ]. The amygdala consists of nuclei such as basolateral amygdala (BLA) and central nucleus of the amygdala (CeA) [ 9 ]. Out of these, the BLA establishes a reciprocal connection with the other brain regions such as orbital prefrontal cortices (PFCs

/kg) or vehicle (10 mL/kg). One hour post drug treatment animals were subjected to the FST. Treatment regimen (anxiolytic evaluation) Male Swiss albino mice (20–25 g) (n=8) were randomly allotted to groups; Group I: vehicle control – 0.5 % gum acacia in normal saline (10 mL/kg, p.o.), Group II-IV: HeMI (6.25, 12.50, and 25 mg/kg, p.o.) and Group V: diazepam (1 mg/kg, p.o.), 1 h post-treatment, the animals were introduced to the EPM. Elevated plus maze test The elevated plus maze test was carried out as described by Braida et al. [ 31 ]. The apparatus consisted of two

, 1990 ; Koob et al., 1993 ; Koob and Heinrichs, 1999 ; Steckler and Holsboer, 1999 ; Reul and Holsboer, 2002 ; Sterner and Kalynchuk, 2010 ; Tovote et al., 2015 ), none provides a global picture on the neuroanatomical basis of exploratory activity in open-field, hole-board, elevated plus-maze, elevated T-maze, defensive withdrawal, and bright-dark box, all at least partially validated tests of anxiety ( File and Wardill, 1975 ; Walsh and Cummins, 1976 ; Roth and Katz, 1979 ; File, 1982 , 2001 ; Crawley, 1985 ; Kulkarni and Sharma, 1991 ; Dawson and

shaker stress on acoustic startle response, pre-pulse inhibition and open fi eld behavior in mice. J Appl Toxicol 27 : 276-283. Dubovicky M, Skultetyova I and Jezova D. (1999). Neonatal stress alters habituation of exploratory behavior in adult male but not female rats. Pharmacol Biochem Behav 64 : 681-686. Ducottet C and Belzung C. (2005). Correlations between behaviours in the elevated plus-maze and sensitivity to unpredictable subchronic mild stress: evidence from inbred strains of mice. Behav Brain Res 156 : 153-162. Effect of long-term caff eine administration