Biol. Chem., Vol. 388, pp. 1053–1059, October 2007 • Copyright by Walter de Gruyter • Berlin • New York. DOI 10.1515/BC.2007.122
Article in press - uncorrected proof
Selenoproteins of the thyroid gland: expression, localization
and possible function of glutathioneperoxidase3
Cornelia Schmutzler1,*, Birgit Mentrup1,a, Lutz
Schomburg1, Cuong Hoang-Vu2, Volker Herzog3
and Josef Köhrle1
1 Institut für Experimentelle Endokrinologie, Charité –
Universitätsmedizin Berlin, Charitéplatz 1,
D-10117 Berlin, Germany
2 Experimentelle und Chirurgische
., Young M., Hong K. L. and Kyong S. P. GlutathionePeroxidase3 Mediates the Antioxidant Effect of Peroxisome Proliferator-Activated Receptor γ in Human Skeletal Muscle Cells. Mol. Cell. Biol. 2009; 29 (1), pp 20-30.
 Valko M., Rhodes C.J. and Moncol J. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact. 2006; 160(1), PP: 1-40.
 Enkhbaatar P. and Traber D. Pathophysiology of acute lung injury in combined burn and smoke inhalation injury. Clin Sci, 2004; 107, pp: 137- 143.
, induction of cathepsin B by E2 in the ovary was reversed after cotreatment with HPTE, and
ERβ expression was induced by HPTE but not E2. In addition, E2 uniquely upregulated glutathioneperoxidase3, glutathione S-transferase, and cytochrome P450 17α-hydroxylase, with no effect of
HPTE. In male mice, mast cell growth factor, clusterin, cyclin A2, and glutathioneperoxidase3 (GPX3)
mRNAs were significantly induced with either E2 or HPTE treatments in the testes, whereas insulin-
like growth factor 1A (IGF-IA) and UDP-glucuronosyltransferase mRNAs were decreased. In the
Delft, A. C. W. Pike, K. L. Kavanagh, M. Sundstrom, W. H. Lee, S. Muller, B. D. Marsden, C. Bountra, U. Oppermann. GPX3: Human glutathioneperoxidase3 , PDB Code: 2R37 (2007). 28 B. A. Shirley (Ed.). Protein Stability and Folding: Theory and Practice , Humana Press, New York (1995). 29 10.1146/annurev.cellbio.24.110707.175333 , B. S. Mamathambika, J. C. Bardwell. Annu. Rev. Cell Dev. Biol. 24 , 211 (2008). 30 10.1006/taap.1996.0191 , C. V. Smith, D. P. Jones, T. M. Guenther, L. H. Lash, B. H. Lauterburg. Toxicol. Appl. Pharmacol. 140 , 1 (1996). 31 10.1002/macp
K. Suzuki Y. Ishii Y. Asakawa S. Takano H. Ohta N. Kuroiwa H. Tanaka K. Shimizu N. Sugano S. Sato N. Nozaki H. Ogasawara N. Kohara Y. Kuroiwa T. 2004 Genome sequence of the ultrasmall unicellular red alga Cyanidioschyzon merolae 10D Nature 428 653 657 Miao, Y., J. Guo, E. Liu, K. Li, J. Dai, P. Wang, J. Chen and C. Song. 2007. Osmotically stress-regulated the expression of glutathioneperoxidase3 in Arabidopsis. Chinese Sci. Bull. 52 : 127–130. Miao Y. Guo J. Liu E. Li K. Dai J. Wang P. Chen J. Song C. 2007 Osmotically stress-regulated the expression of
, Bober J. [Polymorphisms in the oxidative stress-related genes and cancer risk]. [Article in Polish]. Ann Acad Med Stetin 2013; 59: 18-28. Janicka A Szymańska-Pasternak J Bober J [Polymorphisms in the oxidative stress-related genes and cancer risk]. [Article in Polish] Ann Acad Med Stetin 2013 59 18 28 23 Lin JC, Kuo WR, Chiang FY, Hsiao PJ, Lee KW, Wu CW, et al. Glutathioneperoxidase3 gene polymorphisms and risk of differentiated thyroid cancer. Surgery 2009; 145: 508-13. 10.1016/j.surg.2008.12.008 19375609 Lin JC Kuo WR Chiang FY Hsiao PJ Lee KW Wu CW
Species on N itrogenase o f Anabaena variabilis 413
Table III. Distribution o f oxygen-radical scavenging enzymes in homo-
genates o f vegetative cells and heterocysts o f air-grown and oxygen-
enriched cultures o f Anabaena variabilisa.
Enzymes and Air-grown culture OTenriched culture
metabolites Vegetative Hetero Vegetative Hetero
cells cysts cells cysts
Catalase n.d. n.d. n.d. n.d.
n.d. 46 2.3 33
0.18 1.3 0.10 2.4
Glutathione reductase3 18 10 40 18
Glutathioneperoxidase3 14 16 29 18
dehydrogenase3 49 170
-apoptotic pathways, and recruitment of the inflammatory cells [ 42 , 44 , 45 , 46 , 47 ]. Besides acting as an anti-protease, the rhSLPI also has other important biological properties; in particular, it increases the glutathione levels in the lung as reported by Gillissen A. et al. [ 15 ]. This suggests that the rhSLPI may be particularly well suited for therapy in diseases characterized by an excess of both the serine proteases and the oxidants [ 15 ]. The previous study from Masterson C.H. et al. found that the overexpression of rhSLPI together with glutathionePeroxidase-3
A, Diebold J,
Hermeking H. Functional epigenomics identifies genes
frequently silenced in prostate cancer. Cancer Res 2005;
19. Yu YP, Yu G, Tseng G, Cieply K, Nelson J, Defrances M,
et al. Glutathioneperoxidase3, deleted or methylated in
prostate cancer, suppresses prostate cancer growth and
metastasis. Cancer Res 2007;67:8043–50.
20. Savic-Radojevic A, Mimic-Oka J, Pljesa-Ercegovac M,
Opacic M, Dragicevic D, Kravic T, et al. Glutathione
S-transferase-P1 expression correlates with increased
antioxidant capacity in transitional cell carcinoma of the
estrogen receptor beta in adipose tissue from postmenopausal women. Menopause 2012;19:1347–52. 54. Lundholm L, Putnik M, Otsuki M, Andersson S, Ohlsson C, Gustafsson JA, Dahlman-Wright K. Effects of estrogen on gene expression profiles in mouse hypothalamus and white adipose tissue: target genes include glutathioneperoxidase3 and cell death-inducing DNA fragmentation factor, alpha-subunit-like effector A. J Endocrinol 2008;196:547–57. 55. Penza M, Montani C, Romani A, Vignolini P, Pampaloni B, Tanini A, Brandi ML, Alonso-Magdalena P, Nadal A, Ottobrini L, Parolini O