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Hormonal regulation of Thyrotropin gene expression W. W. Chin Introduction Thyrotropin (TSH) is the major regulator of thyroid gland growth and function in mammals and lower species. It interacts with its specific receptor on the plasma membrane of thyroid follicular cells to induce the production of thyroid hormones (TH). The T H produced by the thyroid gland then act on many tissues to regulate metabolic functions. Of special note, T H also act on the TSH- producing cell or thyrotrope located in the anterior pituitary gland to inhibit both the release

Neural and Pituitary Mechanisms Involved in Growth Hormone Regulation Marie-Therese Bluet-Pajot, Jerome Bertherat, Jacques Epelbaum and Claude Kordon Unitä de Recherche sur la Dynamique des Systimes Neuroendocriniens (U159), INSERM, Iter rue d'AMsia, 75014 Paris, France As for most pituitary hormones, secretion of growth hormone (GH) exhibits a pulsatile pattern. The frequency and amplitude of GH secretory episodes appear to be a species characteristic; in man there are approximately 4- 5 peaks each day, with a predominant one in the early night hours

HORMONAL REGULATION OF POSTNATAL DEVELOPMENT OF RENAL TUBULAR TRANSPORT PROCESSES H. Bräunlich Institute of Pharmacology and Toxicology, Friedrich Schiller University 3ena, DDR-6900 Oena, G.D.R. Int roduction Weak organic anions were excreted by a carrier-mediated trans- port. The reason for the immaturity of this renal tubular transport system is unknown. It was speculated that a multi- hormonal sensitive receptor site exist regulating the postnatal development of renal tubular cells (1). Thyroid hormones are of importance for imprinting of protein

estrogenic hormones increase lordosis be hav ior is by revving up the transcription of OT and the OT receptor genes. Enkephalin and the Delta Opioid Receptor Gary Romano, whose laboratory skills I lauded earlier, not only wanted to study estrogen effects on the opioid peptide gene for preproenkeph- alin (PPE) but also to determine whether there is a sex difference in ste roid hormone regulation of PPE gene expression. Slot blot hybrid- ization analyses of RNA isolated from the VMH indicated that estrogen treatment increased the PPE mRNA levels in the ventrolateral

Biol. Chem. Hoppe-Seyler Vol. 366, pp. 1033-1039, November 1985 Steroid Hormone Regulation of Prostatic Acid Phosphatase Expression in Cultured Human Prostatic Carcinoma Cells Peter SCHULZ3, Hartwig W. BAUERb and Friedrich FITTLER* a Institut für Physiologische Chemie, Physikalische Biochemie und Zellbiologie der Universität München b Freie Universität Berlin, Universitätsklinikum Steglitz, Urologische Klinik und Poliklinik (Received 12 August 1985) Summary: We have investigated the modulation of prostatic acid phosphatase expression in the human prostatic cancer

21 Biochemical Aspects of Hormonal Regulation of Sex Expression in Cucurbits jehoshua Rudich ABSTRACT. Sex expression in the Cucurbitaceae is affected by day length, tempera- ture, and genetic and hormonal controls. Ethylene may be the primary hormone affecting femaleness in cucumbers, muskmelons, and squash, an involvement sug- gested by the detection of ethylene evolution from flower buds and apices. Gynoecious cucumber cultivars were found to have a higher ethylene evolution than other cucumber genotypes. Environmental factors promoting femaleness

Ohtsuka et al.: Regulation of glycogen synthase and phosphorylase in human leukocytes 679 J. Clin. Chem. Clin. Biochem. Vol. 26, 1988, pp. 679-684 © 1988 Walter de Gruyter & Co. Berlin · New York Hormonal Regulation of Glycogen Synthase and Phosphorylase Activities in Human Polymorphonuclear Leukocytes By Yoshinori Ohtsuka, Takahito Kondo and Yoshikazu Kawakami First Department of Medicine, Hokkaido University School of Medicine, Sapporo 060, Japan (Received April 7/August 16, 1988) Summary: Hormonal regulation of glycogen synthase and phosphorylase activities

Hormonal Regulation of Acetylcholinesterase in an Epithelial Cell Line from Chironomus tentans Margarethe Spindler-Barth Institu t für Zoologie, H einrieh-H eine-U niversität Düsseldorf, U niversitätsstraße 1, D-4000 D üsseldorf, Bundesrepublik D eutschland Z. N aturforsch . 46c, 1089- 1093 (1991); received M ay 10/July 17, 1991 Chirunumus, Cell Line, Acetylcholinesterase, Ecdysteroid, M oulting H orm one A cetylcholinesterase (A chE) can be induced in a non-neuronal, epithelial cell line from Chi­ ronomus tentans by the m oulting horm one 20-OH-ecdysone. M

© Freund Publishing House Ltd., London Journal of Pediatric Endocrinology & Metabolism, 11, 607-613 (1998) Possible Role of Plasma Neurotensin on Growth Hormone Regulation in Neonates Mauro Bozzola1, Agnes Ntodou-Thome2, Gianni Bona3, Michele Autelli4, Maria Luisa Magnani1, Giorgio Radetti5 and Rose-Marie Schimpff2 'Department of Pediatrics, University of Pavia, Pavia, Italy; 2INSERM U 339, Paris, France; 3 Department of Pediatrics, University ofNovara, Novara, Italy; 4Department of Clinical Chemistry, IRCCS Policlinico San Matteo, Pavia, Italy;5

Abstract

Average life span has increased because of medical and environmental factors, but maximal life span remains unchanged. Understanding the mechanisms of aging will help to reduce age-related morbidity and facilitate healthy aging. Unlike female menopause, which is accompanied by an abrupt and permanent cessation of ovarian function (both folliculogenesis and estradiol production), male aging does not result in either cessation of testosterone production or infertility. Although the circulating serum testosterone concentration does decline with aging, in most men this decrease is small, resulting in levels that are generally within the normal range. Age-related hypogonadism has been referred to as andropause or late-onset hypogonadism (LOH), with LOH considered to be the most suitable term for this condition. Hormone therapy (HT) trials have caused both apprehension and confusion about the overall risks and benefits associated with HT treatment. During aging, a gradual decline in the potency of the heat shock response occurs, and this may prevent the repair of protein damage. Thus, the interest in developing pharmacological agents capable of inducing stress responses is growing within the broad frame of hormesis, which underlie strategies for optimal patient treatment of numerous diseases. Vitagenes encode for heat shock proteins, thioredoxin, and sirtuin protein systems. Nutritional antioxidants have recently been demonstrated to be neuroprotective through the activation of hormetic pathways, including vitagenes. Here, we focus on possible signaling mechanisms involved in the activation of vitagenes resulting in enhanced defense against bioenergetic defects leading to degeneration and cell death with consequent impact on longevity processes.