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DOI 10.1515/ntrev-2012-0040      Nanotechnol Rev 2013; 2(2): 201–213 Review Weihsu Claire Chen , Jonathan P. May and Shyh-Dar Li * Immune responses of therapeutic lipid nanoparticles Abstract: Nanoparticle-based drug delivery is an emerging technology for targeting therapeutics to the diseased site for enhanced therapy and reduced toxicity. A number of pharmaceutical products that involve nanotechnol- ogy have been approved for clinical use, and because of altered pharmacokinetics and biodistribution, their pro- files of interaction with host

[1] Ammann, R., W., Eckert, J. (1996): Cestodes: Echinococcus. In: Weinstock, J.V. (Ed) Parasitic diseases of the liver and intestines. Philadelphia PA, Saunders, pp. 655–689 [2] Antolová, D., Reiterová, K. (2010): Influence of Echinococcus multilocularis infection on reproduction and cellular immune response of mice. Parasite Immunol., 32: 384–387. DOI: 10.1111/j.1365-3024.2009.01194.x http://dx.doi.org/10.1111/j.1365-3024.2009.01194.x [3] Auer, H., Hermentin, K., Aspöck, H. (1988): Demonstration of a Specific Echinococcus multilocularis Antigen in the

kinetics of the mucosal immune responses in mice. Exp. Parasitol., 75: 99–111 http://dx.doi.org/10.1016/0014-4894(92)90125-T [7] Dick, T. A., Wright, K. A. (1973): The ultrastructure of cuticle of the nematode Syphacia obvelata (Rudolphi, 1802). I. The body cuticle of larvae males, and females, and observation on its development. Can. J. Zool., 51: 187–196 [8] Gilioli, R., Andrade, L. A. G., Passos, L. A. C., Silva, F. A., Rodrigues, D. M., Guaraldo, A. M. A. (2000): Parasite survey in mouse and rat colonies of Brazilian laboratory animal houses kept under different

Biol. Chem., Vol. 389, pp. 457–467, May 2008 • Copyright by Walter de Gruyter • Berlin • New York. DOI 10.1515/BC.2008.061 2008/302 Article in press - uncorrected proof Review Adaptive immune responses to hepatitis C virus: from viral immunobiology to a vaccine Robert Thimme, Christoph Neumann-Haefelin, Tobias Boettler and Hubert E. Blum* Department of Medicine II, University Hospital Freiburg, D-79106 Freiburg, Germany * Corresponding author e-mail: hubert.blum@uniklinik-freiburg.de Abstract Hepatitis C virus (HCV) causes chronic infection in approximately two

activation of an immune response. 11 Radiotherapy is one of the principal treatment modalities for primary tumors and their metastases. 12 Nowadays, irradiation is widely investigated for its associated effects on priming antitumor immunity. 13 There is growing evidence of irradiation’s effect on the antitumor immune response, inducing immunogenic cell death and generating danger signals. An important danger signal after irradiation is DNA released from the nucleus of dying cells. This DNA is recognized by the immune system as a DAMP, and can promote the activation of

-267. 12. Wuryastuti H.J., Stowe H.D., Bull R.W., Miller E.R.: Effects of vitamin E and selenium on immune responses of peripheral blood, colostrum, and milk leukocytes of sows. J Anim Sci 1993, 71, 2464-2472.

a combination is predominantly observed in under- privileged people of developing countries, particularly in rural regions. Several micronutrients such as trace elements (zinc, iron, selenium) modulate immune function and influence the susceptibility of the host to infection. Nevertheless, the effect of individual mi- cronutrients on components of innate immunity is dif- ficult to design and interpret. Micronutrient defi- ciency, in general, has a widespread effect on nearly all components of the innate immune response. Cha- gas’ disease is a pertinent model to

Clin Chem Lab Med 2007;45(10):1366–1372 2007 by Walter de Gruyter • Berlin • New York. DOI 10.1515/CCLM.2007.278 2007/111 Article in press - uncorrected proof Methylprednisolone, cortisol and the cell-mediated immune response in children after ventricular septal defect repair Stefan Grosek1,*, Alojz Ihan2, Branka Wraber2, Tone Gabrijelcic3, Miro Kosin3, Josko Osredkar4, Günter Gmeiner5, Iztok Grabnar6 and Janez Primozic1 1 Department of Paediatric Surgery and Intensive Care, University Medical Centre Ljubljana, Ljubljana, Slovenia 2 Institute of Microbiology

., Krzyżowska M., Długosz E., Zygner W., Górski P., Wędrychowicz H. 2013b. Molecular cloning and characterisation of in vitro immune response against astacinlike metalloprotease Ace-MTP-2 from Ancylostoma ceylanicum. Experimental Parasitology, 133, 472–482. DOI: 10.1016/j.exppara.2013.01.006. http://dx.doi.org/10.1016/j.exppara.2013.01.006 [4] Clery D.G., Mulcahy G 1998. Lymphocyte and cytokine responses of young cattle during primary infection with Fasciola hepatica. Research in Veterinary Science, 65,169–171. http://dx.doi.org/10.1016/S0034-5288(98)90171-0 [5] De Maere V

acalculous cholecystitis associated with Sarcocystis infection in a patient with AIDS. Acta Parasitol 2014, 59:310–315. 12. Spencer JA, Deinnocentes P, Moyana EM, Guarino AJ, Ellison SE, Bird RC, Blagburn BL. Cytokine gene expression in response to SnSAG1 in horses with equine protozoal myeloencephalitis. Clin Diagn Lab Immunol 2005, 12:644–646. 13. Olias P, Meyer A, Klopfleisch R, Lierz M, Kaspers B, Gruber AD: Modulation of the host Th1 immune response in pigeon protozoal encephalitis caused by Sarcocystis calchasi. Vet Res 2013, 44:10. 14. Shapira S, Speirs K