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-collimated configuration with mono-energetic proton beams of 165 MeV and 224 MeV, respectively. Results acquired by means of trans- versal PGS at different phantom depths, ranging from 6 cm before the Bragg peak (BP) to 3.5 cm beyond the BP in 5 mm steps with a 1 cm slit collimation (tungsten) showed a slight decrease of PG yields after the BP. Similar measurements with a semi-opened collimation configuration demonstrated a steeper decrease of PG yields after the BP. Keywords: cerium-bromide, prompt-gamma, time-of-flight, proton therapy, range verification, gamma

compton camera prototype for particle beam range verification Silvia Liprandi, Medizinische Physik, Ludwig Maximilians Universitaet Muenchen, Garching, Deutschland, Saad Aldawood, Medizinische Physik, Ludwig Maximilians Universitaet Muenchen, Garching, Deutschland, Tim Binder, Medizinische Physik, Ludwig Maximilians Universitaet Muenchen, Garching, Deutschland, Georgios Dedes, Medizinische Physik, Ludwig Maximilians Universitaet Muenchen, Garching

Lozano, Katia Parodi, Peter G. Thirolf: LMU München, Medical Physics Department, Germany 656 SCATTERER / TRACKER ABSORBER 50 mm 85 mm e -  10 mm each groups investigate the possibilities for a range verification and in-vivo dosimetry via prompt gamma radiation from nuclear reactions, either employing passively collimated imaging devices or electronically collimated systems based on the Compton-camera principle. 1.1 The Compton camera system In general, a Compton camera setup consists of a scatter and an absorber component. In a conventional

different phantom materials especially in T2-weighted images (except for the bone surrogate). T2- weighted readout of the dosimetric gel allowed approximate proton range verification. Fusing 3D printing with the usage of gels and designing phantoms based on patient imaging data enabled the development of an anthropomorphic multimodality head phantom prototype that successfully underwent every step in proton therapy treatment. Abstracts - BMTMedPhys 2017 – Dresden, September 10–13 • DOI 10.1515/bmt-2017-5103 Biomed. Eng.-Biomed. Tech. 2017; 62(s1): S534–S539 • © by

protocol. Carryover, matrix effect, reference range verification, precision studies for creatinine were performed according to the CLSI EP10-A3, CLSI EP14-A2, CLSI EP28-A3c protocols and CLSI EP05-A2, respectively [ 9 ]. Thus, 40 serum samples from 20 healthy female and male were analyzed by LC-MS/MS method, and the obtained results were compared with the creatinine reference ranges of the Mayo Medical Laboratory. The reference intervals of serum creatinine were 0.8–1.3 mg/dL for adult male (n=20), and 0.6–1.1 mg/dL for adult female (n=20). Statistical analysis

range telescope. The implemented RMF model predicted a mean RBE of 1.26 for the carbon-iCT with a physical dose of 40mGy. This study quantitatively presents the experimental outcomes of a multi-ion iCT comparison and puts forward the clinical potential for range verification in ion-beam therapy, with a focus on the biological dose calculation. Future investigations aim at extending the multi-ion comparison with particular reference to the biological response for low-dose imaging and the use of iCTs for treatment planning. Abstracts - BMTMedPhys 2017 – Dresden


Ion-Beam Therapy Centre (HIT), Germany); Malte Ellerbrock (Heidelberg Ion-Beam Therapy Centre (HIT), Germany); Oliver Jäkel (Heidelberg Ion-Beam Therapy Centre (HIT), Germany; German Cancer Research Centre, Germany) Session 9 Radiation therapy II – Particle therapy I V 37 11.09.2017 08:30 Optimization of a compton camera prototype for particle beam range verification Silvia Liprandi (Ludwig Maximilians Universitaet Muenchen, Germany); Saad Aldawood (Ludwig Maximilians Universitaet Muenchen, Germany; King Saud University, Saudi Arabia); Tim Binder (Ludwig

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 al. Patient study of in vivo verification of beam deliv- ery and range, using positron emission tomography and computed tomography imaging after proton therapy. Int J Radiat Oncol Biol Phys. 2007;68(3):920–934. 21. Knopf A, Parodi K, Paganetti H, et al. Quantitative assessment of the physical potential of proton beam range verification with PET/CT. Phys Med Biol. 2008;53(15):4137–4151. 22. Malyapa R, Lowe M, Bolsi A, et al. Evaluation of robustness to setup and range uncer- tainties for head and neck patients treated with pencil beam scanning proton therapy. Int J

indirect existence proof by turns of phrase so foolish that I cannot reproduce them here. The second part of Ambrose’s article contains clear intimations of Wittgenstein’s verificationist philosophy that prevented him from accepting predicate logic, as in “with general forms of infinite range, ‘verification by exhibition of instances’ is meaningless” (p. 319). That objection against universal quantification has force only if the method 6.2 Stricter than Skolem: Wittgenstein and His Students • 157 of proof by generalization is absent. Another characteristic passage is (p