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determined here by in situ hybridization and Northern blotting experiments, glutathione peroxidases (GPx) 1 and 4 and selenoprotein P were moderately expressed, occurring selectively in the follicular cells and in leuko- cytes of germinal follicles of thyroids affected by Hashi- moto’s thyroiditis. Selenoprotein 15 was only marginally expressed and distributed over all cell types. GPx3 mRNA was exclusively localized to the thyrocytes, showed the highest expression levels and was down- regulated in 5 of 6 thyroid cancer samples as compared to matched normal controls. GPx3