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-Oleas, Servicio de Inmunologı́a, Edificio de Laboratorios, 3a planta, Hospital Universitario Virgen del Rocı́o, Avenida Manuel Siurot s/n, 41013, Sevilla, Spain Phone: q34-955013231, Fax: q34-955013221, E-mail: Keywords: anti-cyclic citrullinated peptide antibodies (anti-CCP); rheumatoid arthritis; rheumatoid factor; third-generation anti-CCP ELISA. Introduction Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic inflammation of peripheral joints, leading to severe destruction. This disease affects between 0.5% and 1% of

disease control group remained high across all three diagnostic markers. Among the studies included in this review, ELISA, with the kit produced by Orgentec Diagnostika GmbH (Germany), recommended the cutoff value at 20 U/mL; while the POCT LFIA device and other immunological assays were also used, with cutoff set at different values. ELISAs were mainly used to detect anti-CCP2 IgG, however, either the second or the third generation anti-CCP ELISA was popularly used among the studies, causing variable cutoff values ranging between 5 and 25 U/mL. Nephelometry was a