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structure demonstrated enhanced leaflet opening and closing as a result of stent deformation and redirected loading. Crimping and subsequent release into the AR model as well as the stent adaption to the target region after expansion proved the suitability of the TAV design for percutaneous application. FEA represented a useful tool for numerical simulation of an entire minimally invasive heart valve prosthesis in relevant clinical scenarios. Keywords: Finite-element analysis, transcatheter aortic valve prosthesis, aortic root model.

(see Figure 3). Only in the normal aortic root a small increase from 3.2 ± 1.2% to 5.2 ± 1.0% was measured (n = 10). Furthermore, the regurgitant fraction increased with grade of stenosis, e.g. from 3.4 ± 1.2% in the normal aortic root to 12.9 ± 0.8% in the mild stenotic root and 16.1 ± 0.9% in the severe stenotic root at a cardiac output of 5 l/min (n = 10), respectively. Figure 3: Regurgitant fraction of a transcatheter aortic valve prosthesis in silicone aortic root models with different grade of stenosis as a function of the

filled with distilled water and tempered to 37°C ± 2°C. With the help of a pump and flow resistances (Figure 1, no. 2-4) a static pres- sure was applied to the TAVP leading to full valve closure. As a result, the measured regurgitation is assumed as solely paravalvular between prosthesis skirt and annulus model. Figure 3: Schematic of transcatheter aortic valve prosthesis in a silicone model of the aortic annulus and implantation depth D which was varied in the range of 0 mm to 6 mm. The static pressure on the valve was increased from