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Pseudo-nitzschia species, TEM. (12–17) P. pseudodelicatissima/P. cuspidata . (12) Linear valve in valve view. (13) Valve apex. (14) Striation showing one row of poroids. (15) Poroids with two hymen sectors. (16) Mid-valve showing a central interspace (arrowhead). (17) Poroids with two to four hymen sectors. (18–21) P. hasleana . (18) Lanceolate valve in valve view. (19) Valve apex. (20) Mid-valve showing a central interspace (arrowhead). (21) Poroids with hymen sectors. Scale bars: 20 μm ( Figure 12 ), 10 μm ( Figure 18 ), 2 μm ( Figure 19 ), 1 μm ( Figure 13 ), 0

REFERENCES 1. Coffey S, Cairns BJ, Iung B. The modern epidemiology of heart valve disease. Heart. 2016 Jan;102(1):75-85. 2. Cribier A. Development of transcatheter aortic valve implantation (TAVI): a 20-year odyssey. Arch Cardiovasc Dis. 2012 Mar;105(3):146-52. 3. Cullen MW, Cabalka AK, Alli OO, Pislaru SV, Sorajja P, Nkomo VT, et al. Transvenous, antegrade Melody valve-in-valve implantation for bioprosthetic mitral and tricuspid valve dysfunction: a case series in children and adults. JACC Cardiovasc Interv. 2013 Jun;6(6):598-605. 4. Schillinger W, Senges J

al. In vitro hemodynamics and valve imaging in passive beating hearts. J Biomech. 2012;45:1133-–9. Leopaldi AM Vismara R Lemma M Valerio L Cervo M Mangini A In vitro hemodynamics and valve imaging in passive beating hearts J Biomech 2012 45 1133 9 [7] Leopaldi AM, Vismara R, Gelpi G, Romagnoni C, Fiore GB, Redaelli A, et al. Intracardiac visualization of transcatheter aortic valve and valve-in-valve implantation in an in vitro passive beating heart. JACC Cardiovasc Interv. 2013;6:92–3. Leopaldi AM Vismara R Gelpi G Romagnoni C Fiore GB Redaelli A Intracardiac

Heart Valve Dis 1999 8 34 41 8. Cheung, AW, Gurvitch, R, Ye, J, Wood, D, Lichtenstein, SV, Thompson, C, et al. Transcatheter transapical mitral valve-in-valve implantations for a failed bioprosthesis: a case series. J Thorac Cardiovasc Surg 2011;141(3):711–5. https://doi.org/10.1016/j.jtcvs.2010.11.026 . 21269643 10.1016/j.jtcvs.2010.11.026 Cheung AW Gurvitch R Ye J Wood D Lichtenstein SV Thompson C Transcatheter transapical mitral valve-in-valve implantations for a failed bioprosthesis: a case series J Thorac Cardiovasc Surg 2011 141 3 711 5 https://doi.org/10

, equipped with a Wild camera, and a (SEM JEOL JSMT 100, Tokyo, Japan) scanning electron microscope. A JEOL 1200 EX (Tokyo, Japan) transmission electron microscope was used for transmission electron microscopy (TEM). Mate- 352 M. Ferrario et al.: Morphology of the diatom Chaetoceros castracanei Figures 8–14. Chaetoceros castracanei: transmission microscopy (TEM) and scanning electron microscopy (SEM). (8) Two sibling valves in valve view, an arrowhead points to the rimoportula, TEM. (9) Internal view of an intercalary valve with the slit of the eccentric rimoportula

prospective pilot study J Cardiovasc Comput Tomograph 2017 11 489 96 https://doi.org/10.1016/j.jcct.2017.09.013 29. Belhaj Soulami, R, Verhoye, JP, Nguyen Duc, H, Castro, M, Auffret, V, Anselmi, A, et al. Computer-assisted transcatheter heart valve implantation in valve-in-valve procedures. Innovations (Phila) 2016;11:193–200. https://doi.org/10.1097/imi.0000000000000259 . 27337529 10.1097/imi.0000000000000259 Belhaj Soulami R Verhoye JP Nguyen Duc H Castro M Auffret V Anselmi A Computer-assisted transcatheter heart valve implantation in valve-in-valve procedures

. Scale bar = 10 μm for all images Figure 2a–g (SEM) Navicula dermochelycola sp. nov.: (a–e) External views of complete valves in valve view, with capitate apices; (f, g) Large and irregular central area with alternating longer and shorter striae (g arrowheads). Note the decussate pattern of areolae. Scale bars 4 μm (a–e); 1 μm (a, f ); 2 μm (g) Figure 3a–d (SEM) Navicula dermochelycola sp. nov. External views: (a) Capitate apex with visible convergent striae. (b) Free open copula without ornamentation. (c) Apex with open copulae and one row of transapically

% a 26-mm Edwards SAPIEN. Two patients exhibited stenosis of biological prostheses and therefore underwent valve-in-valve procedures. Device implantation was successfully performed in all patients. There was no case of conversion to heart surgery, but two patients received AVR within 3 months after the procedure: one because of symptomatic severe paravalvular regurgitation and the other because of delayed dislocation of the device (at day 7). A share of 19% had more than mild (≥II) residual aortic regurgitation. Baseline characteristics of the total group prior to