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-MS/MS system for plant metabolomics. Comput Struct Biotechnol J 4: e201301011. Wang C., Horby P.W., Hayden F.G., Gao G.F. (2020): A novel coronavirus outbreak of global health concern. The Lancet 395: 470–473.

PIŚMIENNICTWO 1. Kahn JS, McIntosh K. History and recent advances in coronavirus discovery. Pediatr Infect Dis. 2005;24:223-7. 2. Zhong N, Zheng BY, Li Y, et al. Epidemiology and cause of severe acute respiratory syndrome (SARS) in Guangdong. People’s Republic of China, in February, 2003. Lancet. 2003;362(9393):1353-8. 3. Wang N, Shi L, Zhang S, et al. Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4. Cell Res. 2013;23:986-90. 4. Lu R, Zhao X, Li J, et al. Genomic characterisation and epidemiology of 2019 novel coronavirus

References Gates B., How to Avoid a Climate Disaster: The Solutions We Have and the Breakthroughs We Need, Kindle Edition, 2020 Figus A., Sistema Europa. L’organizzazione politica dell’Unione europea, il complesso cammino verso l’unione politica. Eurilink University Press, Rome, 2019. Web references www.money.it www.lastampa.it http://www.lazardfreresgestion.fr www.oecd.com www.who.int www.salute.gov.it https://ec.europa.eu/health/home http://www.cdc.gov/ncidod/EID/vol10no2/03-0812.htm . http://www.governo.it/it/coronavirus-dieci-regole https

Introduction Coronavirus disease 2019, abbreviated to COVID-19, is a viral infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) [ 1 ], [ 2 ]. As with other members of the Coronaviridae family, inter-human transmission of this microorganism is mostly due to respiratory tract infection, mediated by the so-called respiratory droplets, which are formed by water and various inclusions, and can be generated while talking, breathing, coughing or sneezing [ 3 ]. Human droplets are circular elements with ~5 μm diameter that rapidly

-called “coronavirus-SARS” was diagnosed in Wuhan, known today as the epicenter of the COVID-19 pandemic ( Report of the WHO 2020 ). Launched by the emergency department at Wuhan Central Hospital, the first alert was rebuffed by a staff inspector who instructed the physician not to speak out to prevent alarming the population. Also on December 30, a young ophthalmologist warned his medical school classmates about a possible “SARS” outbreak affecting seven people using We Chat – he also became infected with SARS-CoV-2 some weeks later, which eventually took his life. That same day

Introduction Coronavirus disease 2019, abbreviated to COVID-19, is the latest biological hazard to assume the relevance of insidious worldwide threat. The responsible pathogen is a virus belonging to the Coronaviridae family, finally defined as “severe acute respiratory syndrome coronavirus 2” (SARS-CoV-2) for high sequence identity (i.e. up to 80%) with the homologous virus which caused the SARS outbreak in 2003 (i.e. SARS-CoV) [ 1 ]. At the time of writing this article, SARS-CoV-2 has already infected over 115,000 people in more than 115 different countries

Introduction Coronaviruses are enveloped, non-segmented, positive-sense RNA viruses, known to cause disease in humans and animals, ranging from common cold to more severe and even deadly respiratory infections [ 1 ]. Since 2003, two highly pathogenic human betacoronaviruses have emerged in two separate outbreaks, i.e. severe acute respiratory syndrome coronavirus (SARS-CoV-1) and Middle East respiratory syndrome coronavirus (MERS-CoV-1) [ 2 ], [ 3 ]. These microorganisms have caused the homologous diseases SARS and MERS, characterized by lower respiratory tract

1 Introduction Novel coronavirus disease (COVID-19, previously known as novel coronavirus pneumonia [NCP]) is an acute pulmonary inflammation caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In December 2019, several cases with pneumonia caused by unknown reasons occurred in Hubei Province, China. Most of these patients worked or lived nearby the local Huanan China Seafood Wholesale Market. Some of them rapidly developed acute respiratory distress syndrome (ARDS) and other complications after a few days of onset. In January 2020

1 Introduction In December 2019, a succession of pneumonia cases, which were later proven to be caused by a novel coronavirus (named as novel coronavirus pneumonia-19 [COVID-19] by the World Health Organization [WHO] on January 12, 2020), emerged in Wuhan City, Hubei Province, China. In the following days, COVID-19 had quickly spread inside of Hubei Province, throughout China and other countries. A global health emergency was declared by the WHO on January 30, 2020 [ 1 , 2 ]. As of March 23, 2020, a total of 3,49,828 COVID-19 cases had been reported in at least

Introduction Since early December 2019, several cases of pneumonia of unknown etiology had been reported in Wuhan, Hubei province, China, and promptly drew much attention [ 1 ], [ 2 ]. Severe acute respiratory infection symptoms occurred in most patients, and some rapidly developed into acute respiratory distress syndrome (ARDS) and acute respiratory failure. In early January 2020, a novel coronavirus was identified from an infected patient using next-generation sequencing by the Chinese Center for Disease Control and Prevention [ 3 ], and was formally named