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Licensed Unlicensed Requires Authentication Published by De Gruyter 2016 (Print 1980)

Analytical Biochemistry of Nickel[*]

  • F. William Sunderman

Abstract

Measurements of nickel in biological materials are reviewed, with emphasis on (a) preliminary steps for oxidation or removal of organic matter; (b) pre-concentration and separation procedures; (c) instrumental techniques for quantitation of nickel; and (d) reference values for nickel concentrations in human body fluids, tissues, and excreta. Electrothermal atomic absorption spectrometry is currently the most sensitive, convenient, and reliable technique for determination of nickel in biological materials, but it is rivalled in sensitivity by three other techniques (differential pulse polarography, particle-induced x-ray emission spectrometry, and gas chromatography). Isotope dilution gas chromatographymass spectrometry may eventually become the definitive method for analysis of nickel in biological materials. Until such a definitive method has been developed, the IUPAC provisional reference method (electrothermal atomic absorption spectrometry) will serve for comparative evaluations of other procedures for clinical measurements of nickel concentrations.

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