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Interrelations of Chemistry and Biotechnology - II. Microbial Degradation of Synthetic Recalcitrant Compounds

Interrelations of Chemistry and Biotechnology–Ii[†]

  • Randi K. Rothmel and M. Ananda

Abstract

Man-made chemicals can often be degraded to varying extents by the natural microflora. Except for simple compounds such as chlorobenzoates, the biochemical and genetic basis of biodegradation is poorly understood. Highly chlorinated compounds, which are not generally subject to rapid biodegradation, may be used as substrates for strains developed under strong selective pressure. Determining the catabolic pathways and defining the regulation of genes involved in degradation is critical for constructing improved bacterial strains capable of enhanced degradation of recalcitrant compounds.

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