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Licensed Unlicensed Requires Authentication Published by De Gruyter 2016 (Print 1995)

National Approaches for Standardisation

From: Pesticides Report 33. Immunoassays for Residue Analysis of Agrochemicals: Proposed Guidelines for Precision, Standardization and Quality Control

  • Arno J. Krotzky and Bernd Zeeh

Abstract

Immunoassays (ELISA) for agrochemicals are analytical techniques which make use of antibodies as “biochemical detectors” for the quantification of active ingredients or their derivatives. In contrast to clinical chemistry the application of immunoanalytics to residue analyses of agrochemicals by industries and the acceptance of ELISA data by registration agencies is still in its infancy. Missing performance quality control criteria for ELISA in the past have raised questions about the reliability of this technique for the analysis of agrochemicals. This report gives basic technical information on immunoassays such as test formats and detection systems. Parameters critical for the reliability of this methodology such as matrix interference and cross reactivity are discussed. Guidelines are proposed for precision requirements, standardised evaluation procedures and the distribution of immunoanalytical methods for agrochemicals. Follow-up activities are summarised with the intention of generating a wide data base on the precision and applicability of immunoassays for agrochemical analysis.

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