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Lead: Its Effects on Environment and Health

Ed. by Sigel, Astrid / Sigel, Helmut / Sigel, Roland K.O.

With contrib. by Aoki, Katsuyuki / Aschner, Michael / Cullen, Jay T. / Farkas, Etelka / Filella, Montserrat / Hauser, Peter / Klotz, Katrin / Küpper, Hendrik / Maret, Wolfgang / Stewart, Theodora J. / Stillman, Martin J. / Pecoraro, Vincent L. / Pohl, Hana R. / Tylkowski, Bartosz

Series:Metal Ions in Life Sciences 17

eBook (PDF)
Publication Date:
April 2017
Copyright year:
2017
ISBN
978-3-11-043433-0
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7. Solid State Structures of Lead Complexes with Relevance for Biological Systems

Aoki, Katsuyuki / Murayama, Kazutaka / Hu, Ning-Hai

Abstract

Structural information on the interaction between lead ion and its targeting biological substances is important not only for enriching coordination chemistry of lead but for successfully treating lead poisoning that is a present-day problem. This chapter provides structural data, mainly metal binding sites/modes, observed in crystal structures of lead complexes with biorelevant molecules, obtained from the Cambridge Structural Database (the CSD version 5.36 updated to May 2015) and the Protein Data Bank (PDB updated to February 2016). Ligands include (i) amino acids and small peptides, (ii) proteins, (iii) nucleic acid constituents, (iv) nucleic acids, (v) simple saccharides, and (vi) other biorelevant molecules involving lead-detoxification agents. For representative complexes of these ligands, some details on the environment of the metal coordination and structural characteristics are described.

Citation Information

Katsuyuki Aoki, Kazutaka Murayama, Ning-Hai Hu (2017). 7. Solid State Structures of Lead Complexes with Relevance for Biological Systems. In Astrid Sigel, Helmut Sigel, Roland K.O. Sigel (Eds.), Lead – Its Effects on Environment and Health (pp. 123–200). Berlin, Boston: De Gruyter. https://doi.org/10.1515/9783110434330-007

Book DOI: https://doi.org/10.1515/9783110434330

Online ISBN: 9783110434330

© 2017 Walter de Gruyter GmbH, Berlin/Munich/BostonGet Permission

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