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Lead: Its Effects on Environment and Health

Ed. by Sigel, Astrid / Sigel, Helmut / Sigel, Roland K.O.

With contrib. by Aoki, Katsuyuki / Aschner, Michael / Cullen, Jay T. / Farkas, Etelka / Filella, Montserrat / Hauser, Peter / Klotz, Katrin / Küpper, Hendrik / Maret, Wolfgang / Stewart, Theodora J. / Stillman, Martin J. / Pecoraro, Vincent L. / Pohl, Hana R. / Tylkowski, Bartosz

Series:Metal Ions in Life Sciences 17

eBook (PDF)
Publication Date:
April 2017
Copyright year:
2017
ISBN
978-3-11-043433-0
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16. Toxicology of Lead and Its Damage to Mammalian Organs

Caito, Samuel / Lopes, Ana Carolina B. Almeida / Paoliello, Monica M. B. / Aschner, Michael

Abstract

The toxicity of lead has been appreciated for centuries. Lead is a commonly used metal in industrialized nations, which results in the release of lead into the environment. Governmental agencies regulate the amount of lead permissible for workers to be exposed to; however, unregulated environmental lead exposure is a high concern. While essential metals have physiologic roles, there are no health benefits from lead intake. In this chapter, we discuss sources of lead exposure, the absorption, distribution, and elimination of lead from the human body, and molecular mechanisms of lead-induced toxicity. We also discuss the evidence on the association between lead exposure and blood pressure, and the influence of sociodemographic, lifestyle and environmental determinants of lead exposure in the general population. We highlight the effects on the nervous system, kidney, immune system, blood, reproductive system, and bones.

Citation Information

Samuel Caito, Ana Carolina B. Almeida Lopes, Monica M. B. Paoliello, Michael Aschner (2017). 16. Toxicology of Lead and Its Damage to Mammalian Organs. In Astrid Sigel, Helmut Sigel, Roland K.O. Sigel (Eds.), Lead – Its Effects on Environment and Health (pp. 501–534). Berlin, Boston: De Gruyter. https://doi.org/10.1515/9783110434330-016

Book DOI: https://doi.org/10.1515/9783110434330

Online ISBN: 9783110434330

© 2017 Walter de Gruyter GmbH, Berlin/Munich/BostonGet Permission

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