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Stem Cells - From Drug to Drug Discovery

Ed. by Haider, Khawaja Husnain

With contrib. by Tong, Cao / Gopu, Sriram / Saleem, Asmat / Khan, Irfan / Naeem, Nadia / Ali, Anwar / Sheikh, Riazuddin / Tarar, Moazzam Nazeer / Mehmood, Azra / Latief, Noreen / Alsharida, Mansour / Abdalla, Elmuataz Elmansi / Afroze, Salman / Zhu, Kai / Guo, Changfa / Ziaee, Seyyed Mohyeddin / Tabeshmehr, Parisa / Lei, Ye

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March 2017
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3. MicroRNAs as modulators of endothelial differentiation of stem cells: role in vascular regenerative medicine

Gündüz, Dursun / Aslam, Muhammad


MicroRNAs (miRNAs) are a class of small (~22 nucleotides), widely distributed and highly conserved non-coding RNA molecules, and they play an important role in posttranscriptional regulation of gene expression by directly targeting mRNA. Embryonic and induced pluripotent stem cells (ESCs and iPSC, respectively) hold great promise for vascular regenerative therapies. However, several limitations currently prohibit their therapeutic use. The importance of miRNAs in controlling the gene expression profile of a particular cell type is emerging and a multitude of miRNAs have been identified that play key roles in determining the fate and differentiation of the pluripotent cells and thus govern the vascular development and regeneration. A combination of pluripotency transcription factors and particular miRNAs not only enhances the pluripotency of stem cells but also has been reported to enhance their endothelial differentiation. This chapter will summarize the findings that focus different miRNA clusters in the induction, maintenance and directed endothelial differentiation of pluripotent stem cells.

Citation Information

Dursun Gündüz, Muhammad Aslam (2017). 3. MicroRNAs as modulators of endothelial differentiation of stem cells: role in vascular regenerative medicine. In Khawaja Husnain Haider (Editor), Stem Cells - From Drug to Drug Discovery (pp. 63–84). Berlin, Boston: De Gruyter. https://doi.org/10.1515/9783110493764-003

Book DOI: https://doi.org/10.1515/9783110493764

Online ISBN: 9783110493764

© 2017 Walter de Gruyter GmbH, Berlin/Munich/BostonGet Permission

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