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Stem Cells - From Drug to Drug Discovery

Ed. by Haider, Khawaja Husnain

With contrib. by Tong, Cao / Gopu, Sriram / Saleem, Asmat / Khan, Irfan / Naeem, Nadia / Ali, Anwar / Sheikh, Riazuddin / Tarar, Moazzam Nazeer / Mehmood, Azra / Latief, Noreen / Alsharida, Mansour / Abdalla, Elmuataz Elmansi / Afroze, Salman / Zhu, Kai / Guo, Changfa / Ziaee, Seyyed Mohyeddin / Tabeshmehr, Parisa / Lei, Ye

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March 2017
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5. The skeletal muscle stem cells: biology and use in regenerative medicine

Alsharidah, Mansour Saleh / Haider, Khawaja Husnain / Abdalla, Elmuataz Elmansi / Mohammed, Salman Afroze Azmi


Despite being considered a postmitotic tissue, skeletal muscle shows extensive reparability capacity in the event of injury and repairs itself by intrinsic repair mechanisms. This reparability of skeletal muscle has been attributed to the existence of satellite cells; a pool of muscle resident population of progenitor cells which are now considered as resident stem cells of skeletal muscle on par with resident stem cells in other organs and tissues. Their loss has been shown to significantly impact the capacity of skeletal muscle to repair itself during postnatal life. Satellite cells are mono-nucleated myogenic cells that are located between the sarcolemma and basement membrane, adherent to existing muscle fibers and lying dormant until stimulated by chemical cues emanating from the muscle injury. Once stimulated, satellite cells show extensive proliferation, migration and fusion with the existing fibers to participate in the regeneration process of the muscle. These characteristics strongly support their candidature as one of the choice cells for use in regenerative medicine as well as carriers of transgene delivery in vivo for stem-cell-based gene therapy. The present chapter discusses at length the biology of satellite cells, their characterization in experimental studies, their successful reprogramming to pluripotency and applications in regenerative medicine and drug development.

Citation Information

Mansour Saleh Alsharidah, Khawaja Husnain Haider, Elmuataz Elmansi Abdalla, Salman Afroze Azmi Mohammed (2017). 5. The skeletal muscle stem cells: biology and use in regenerative medicine. In Khawaja Husnain Haider (Editor), Stem Cells - From Drug to Drug Discovery (pp. 111–128). Berlin, Boston: De Gruyter. https://doi.org/10.1515/9783110493764-005

Book DOI: https://doi.org/10.1515/9783110493764

Online ISBN: 9783110493764

© 2017 Walter de Gruyter GmbH, Berlin/Munich/BostonGet Permission

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