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Stem Cells - From Drug to Drug Discovery

Ed. by Haider, Khawaja Husnain

With contrib. by Tong, Cao / Gopu, Sriram / Saleem, Asmat / Khan, Irfan / Naeem, Nadia / Ali, Anwar / Sheikh, Riazuddin / Tarar, Moazzam Nazeer / Mehmood, Azra / Latief, Noreen / Alsharida, Mansour / Abdalla, Elmuataz Elmansi / Afroze, Salman / Zhu, Kai / Guo, Changfa / Ziaee, Seyyed Mohyeddin / Tabeshmehr, Parisa / Lei, Ye

eBook (PDF)
Publication Date:
March 2017
Copyright year:
2017
ISBN
978-3-11-049376-4
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8. “Paracrining” the heart with stem cells

Lei, Ye / Haider, Khawaja Husnain

Abstract

Cell-based therapy is being investigated in preclinical and clinical settings with encouraging results. The beneficial effects of cell-based therapy for the treatment of infarcted hearts are believed to be mediated partially by paracrine mechanism. The paracrine mediators released by donor cells have biological functions to modulate inflammation, inhibit cardiomyocyte apoptosis, promote cytoprotection, proliferation, angiogenesis, reduce fibrosis and enhance myogenic repair of the diseased heart. However, the understanding of the mechanism underlying the observed therapeutic effects exerted by paracrine mediators is still limited. Here, we summarize the paracrine factors and associated mechanisms during cell-based therapy of infarcted hearts based on available data with a special focus on the cell types that, after extensive characterization in vitro and during preclinical studies, have progressed to clinical evaluation in the human patients.

Citation Information

Ye Lei, Khawaja Husnain Haider (2017). 8. “Paracrining” the heart with stem cells. In Khawaja Husnain Haider (Editor), Stem Cells - From Drug to Drug Discovery (pp. 176–203). Berlin, Boston: De Gruyter. https://doi.org/10.1515/9783110493764-008

Book DOI: https://doi.org/10.1515/9783110493764

Online ISBN: 9783110493764

© 2017 Walter de Gruyter GmbH, Berlin/Munich/BostonGet Permission

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