Characterization of Biological Membranes
Structure and Dynamics
Ed. by Nieh, Mu-Ping / Heberle, Frederick A. / Katsaras, John
With contrib. by Bowerman, Charles / Bozelli Junior, José Carlos / Brown, Michael F. / Butler, Paul D. / Chan, Chun / Cheng, Xiaolin / Cherniavskyi, Yevhen / Cheung, Eugene / Chini, Corryn E. / Craig, Andrew F. / Dabney-Smith, Carole / Davis, James H. / Dimova, Rumiana / DiPasquale, Mitchell / Eells, Rebecca / Epand, Richard M. / Fisher, Alessandro / Frank, Kilian / Gorman, Brittney L. / Harroun, Thad A. / Heinrich, Frank / Hoogerheide, David P. / Kelly, Elizabeth G. / Kienzle, Paul A. / Kiessling, Volker / Komorowski, Karlo / Konkolewicz, Dominik / Kraft, Mary / Kučerka, Norbert / Li, Ying / London, Erwin / Lorigan, Gary A. / Lösche, Mathias / Majkrzak, Charles F. / Marquardt, Drew / Nagao, Michihiro / Nguyen, Michael H.L. / Nickels, Jonathan / Poloni, Laura / Sahu, Indra D. / Salditt, Tim / Schick, Michael / Schmidt, Miranda / Shen, Zhingiang / Steinkühler, Jan / Tamm, Lukas K. / Tieleman, Peter / Uhríková, Daniela / Won, Amy / Xia, Yan / Ye, Huilin / Yeager, Ashley N. / Yip, Christopher M.
Series:De Gruyter STEM
- eBook (PDF)
- Publication Date:
- July 2019
- Copyright year:
1. Biophysical perspectives of lipid membranes through the optics of neutron and X-ray scattering
Kučerka, Norbert / Uhríková, Daniela
Throughout the biological world, cell membranes are crucial to life, with lipids being one of their major components. Although the basic notion of the fluid mosaic model still holds true, the plasma membrane has been shown to be considerably more complex, especially with regard to the diversity and function of lipids. Besides proteins playing an active role in carrying out the various functions that take place in a biological membrane, much attention has recently focused on the importance of lipids in membrane function. After all, how better to explain the diversity of lipids found in nature? Biological membrane mimetics, such as liposomes, lipid bilayers, and model membranes, are used in a broad range of scientific and technological applications due to the unique physical properties of these supramolecular aggregates of amphiphilic molecules. They serve as platforms for studying the soft matter physics of membranes and membrane dynamics, interactions of bilayers with drugs or biologically important molecules like DNA or peptides, and effects of various additives or environmental changes. The modern state-of-the-art research takes advantage of joining brilliance of X-ray scattering sources with some peculiar properties of neutrons and combines results with the power of computer simulations. The advances in chemistry, and deuteration possibilities in particular, allow for better experimental spatial resolution and possibility to pinpoint labels within membranes. It is only a matter of time for many biological functions that occur at the membrane interface to be matched with the structural properties of these membranes. Several examples of pursuing correlations between the structural results of model biomembrane and functions taking place therein will be discussed.
Norbert Kučerka, Daniela Uhríková (2019). 1. Biophysical perspectives of lipid membranes through the optics of neutron and X-ray scattering. In Mu-Ping Nieh, Frederick A. Heberle, John Katsaras (Eds.), Characterization of Biological Membranes: Structure and Dynamics (pp. 1–42). Berlin, Boston: De Gruyter. https://doi.org/10.1515/9783110544657-001
Book DOI: https://doi.org/10.1515/9783110544657
Online ISBN: 9783110544657© 2019 Walter de Gruyter GmbH, Berlin/Munich/Boston