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Characterization of Biological Membranes

Structure and Dynamics

Ed. by Nieh, Mu-Ping / Heberle, Frederick A. / Katsaras, John

With contrib. by Bowerman, Charles / Bozelli Junior, José Carlos / Brown, Michael F. / Butler, Paul D. / Chan, Chun / Cheng, Xiaolin / Cherniavskyi, Yevhen / Cheung, Eugene / Chini, Corryn E. / Craig, Andrew F. / Dabney-Smith, Carole / Davis, James H. / Dimova, Rumiana / DiPasquale, Mitchell / Eells, Rebecca / Epand, Richard M. / Fisher, Alessandro / Frank, Kilian / Gorman, Brittney L. / Harroun, Thad A. / Heinrich, Frank / Hoogerheide, David P. / Kelly, Elizabeth G. / Kienzle, Paul A. / Kiessling, Volker / Komorowski, Karlo / Konkolewicz, Dominik / Kraft, Mary / Kučerka, Norbert / Li, Ying / London, Erwin / Lorigan, Gary A. / Lösche, Mathias / Majkrzak, Charles F. / Marquardt, Drew / Nagao, Michihiro / Nguyen, Michael H.L. / Nickels, Jonathan / Poloni, Laura / Sahu, Indra D. / Salditt, Tim / Schick, Michael / Schmidt, Miranda / Shen, Zhingiang / Steinkühler, Jan / Tamm, Lukas K. / Tieleman, Peter / Uhríková, Daniela / Won, Amy / Xia, Yan / Ye, Huilin / Yeager, Ashley N. / Yip, Christopher M.

Series:De Gruyter STEM

eBook (PDF)
Publication Date:
July 2019
Copyright year:
2019
ISBN
978-3-11-054465-7
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11. Study of mitochondrial membrane structure and dynamics on the molecular mechanism of mitochondrial membrane processes

Bozelli Junior, José Carlos / Epand, Richard M.

Abstract

Mitochondria play a crucial role in ATP generation and cellular energy homeostasis as well as being recognized for their other vital functions in various biosynthetic and cell signaling pathways. It is now accepted that mitochondria were acquired in an endosymbiotic event about 2 billion years ago when an alphaproteobacterium was engulfed by a eukaryotic progenitor. Like their bacterial ancestor, mitochondria are composed of two separate and functionally distinct outer and inner membranes (MOM and MIM, respectively) that encapsulate the intermembrane space and matrix compartments, respectively. The presence of two distinct bilayers makes the mitochondrial membrane structure complex. The major phospholipid composition of the smooth MOM of most mammalian cells is phosphatidylcholine (PC), phosphatidylethanolamine (PE), and phosphatidylinositol (PI). On the other hand, the highly folded MIM is enriched in nonbilayer forming lipids such as cardiolipin (CL) and PE. In addition, the physical interaction of MOM with other organelles (ER and peroxisomes) and MIM allows a highly dynamic trafficking of molecules among these locations, adding an additional intricacy to the system. Here we review the structure of mitochondrial membranes as well as the dynamics of its lipid constituents and how these are involved in the molecular mechanisms of mitochondrial membrane processes in pathophysiological conditions. Furthermore, a discussion is made on how the lipid-phase state, driven by membrane curvature or other properties related to the packing of lipids, can lead to substrate acyl chain specificity of a MIM enzyme, tafazzin. Finally, we present some of the extensive information one can get about the membrane structure and dynamics using the spectroscopic technique, nuclear magnetic resonance (NMR), focusing on the study of mitochondrial membranes.

Citation Information

José Carlos Bozelli Junior, Richard M. Epand (2019). 11. Study of mitochondrial membrane structure and dynamics on the molecular mechanism of mitochondrial membrane processes. In Mu-Ping Nieh, Frederick A. Heberle, John Katsaras (Eds.), Characterization of Biological Membranes: Structure and Dynamics (pp. 365–390). Berlin, Boston: De Gruyter. https://doi.org/10.1515/9783110544657-011

Book DOI: https://doi.org/10.1515/9783110544657

Online ISBN: 9783110544657

© 2019 Walter de Gruyter GmbH, Berlin/Munich/BostonGet Permission

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