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Stem Cells – From Hype to Real Hope

Ed. by Haider, Khawaja Husnain / Aziz, MD, Salim

Publication Date:
December 2018
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3. Cell-free therapy with stem cell secretions: protection, repair, and regeneration of the injured myocardium

Haider, Khawaja Husnain / Aslam, Muhammad


Experimental animal studies conducted during the last two decades have supported and reflected on the myocardial regenerative potential of bone-marrowderived stem/progenitor cells. Although the encouraging results emanating from clinical trials on bone marrow cells, which are now in phase III, provide little evidence to support their cardiogenic differentiation post transplantation in the patient heart, the beneficial effects of stem-cell-based therapy are being predominantly attributed to the paracrine activity of the donor bone marrow cells. Bone marrow cells secrete a plethora of trophic factors, including chemokines, cytokine, growth factors, micro- RNAs, microvesicles, etc., as part of their secretome, which is unique for each of its constituent cell lineages but variable in composition due to altered responsiveness of the secreting cells to their ever-changing microenvironment. Given the important role of paracrine secretions in various stem cell functions, there is a growing inclination to use stem cell conditioned medium either alone or in combination with cell-based therapy for myocardial regeneration. This chapter discusses in depth the usefulness of cell-free therapy for myocardial regeneration and elaborates on how various processes ranging from host cardiomyocyte survival to mobilization and homing-in of the host progenitor cells to heart are stimulated by treatment with a cell-free conditioned medium to ensure preservation as well as recovery of the recipient heart function.

Citation Information

Khawaja Husnain Haider, Muhammad Aslam (2018). 3. Cell-free therapy with stem cell secretions: protection, repair, and regeneration of the injured myocardium. In , (Eds.), Stem Cells – From Hype to Real Hope (pp. 34–70). Berlin, Boston: De Gruyter. https://doi.org/10.1515/9783110587043-003

Book DOI: https://doi.org/10.1515/9783110587043

Online ISBN: 9783110587043

© 2018 Walter de Gruyter GmbH, Berlin/Munich/BostonGet Permission

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