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Stem Cells – From Hype to Real Hope

Ed. by Haider, Khawaja Husnain / Aziz, MD, Salim

eBook (PDF)
Publication Date:
December 2018
Copyright year:
2019
ISBN
978-3-11-058704-3
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4. Myoblasts provide safe and effective treatments for hereditary muscular dystrophies, cardiomyopathies, type 2 diabetes, solid tumors, and aging

Law, Peter K. / Law, Danlin M. / Ye, Lei / Haider, Khawaja Husnain / Song, Shi Jun / Lu, Ping / Ma, Jian-Hua / Ren, Jun

Abstract

In the 500 million years of vertebrate evolution, the skeletal muscle, being externally located in the body, has developed specific characteristics for frontline defense against predation, including diseases. Myoblast implantation is a unique, patented technology of muscle regeneration having been tested in phase III clinical trials of muscular dystrophy and ischemic cardiomyopathy, phase II trial of cancer, and phase I trial of type 2 diabetes. Differentiated and committed, myoblasts are not stem cells. They fuse spontaneously and develop to form “new” myofibers, replenishing skeletal myofibers in muscular dystrophy. They develop to become cardiomyocytes in the infracted myocardium. They also fuse with degenerative myofibers of muscular dystrophy or type 2 diabetes, transferring their nuclei containing the normal human genome to provide stable, long-term expression of the missing gene products. When billions of myoblasts are injected into a solid tumor, membrane breakage prior to cell fusion releases high concentration of tumor necrosis factor-α to inhibit cancer growth and metastasis by inducing apoptosis and cell cycle arrest of cancer cells. Newly formed myotubes use up most of the nutrients and oxygen within the tumor and starve the cancer cells. They wrap around cancer cells and prevent them from metastasis. Furthermore, myoblast allograft generates antibodies and triggers localized immune attack on the cancer cells nearby. Myoblasts, because of their small size, spindle shape, and resilience, grow readily within wrinkles and on skin surfaces, thus enhancing the color, luster, and texture of the skin “plated” with them. They can be injected subcutaneously as a cellular filler to reduce wrinkles. Intramuscular injection of myoblasts can augment the size, shape, consistency, tone, and strength of muscle groups, improving the lines, contours, and vitality from the sculpture for a youthful appearance. This highly promising technology has great social economic values in treating hereditary, fatal, and debilitating disease conditions.

Citation Information

Peter K. Law, Danlin M. Law, Lei Ye, Khawaja Husnain Haider, Shi Jun Song, Ping Lu, Jian-Hua Ma, Jun Ren (2018). 4. Myoblasts provide safe and effective treatments for hereditary muscular dystrophies, cardiomyopathies, type 2 diabetes, solid tumors, and aging. In , (Eds.), Stem Cells – From Hype to Real Hope (pp. 71–97). Berlin, Boston: De Gruyter. https://doi.org/10.1515/9783110587043-004

Book DOI: https://doi.org/10.1515/9783110587043

Online ISBN: 9783110587043

© 2018 Walter de Gruyter GmbH, Berlin/Munich/BostonGet Permission

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