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Acta Chemica Iasi

The Journal of "Alexandru Ioan Cuza" University from Iasi

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2067-2446
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Diazolium Salts with Dihydroxyacetophenone Skeleton with Anticipated Anticancer and Antibacterial Activity

Dorina Mantu
  • Department of Chemistry, “Al.I. Cuza” University Iasi, 11 Carol I Bd, Iasi 700506, Romania
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/ Eliza Ene
  • Department of Chemistry, “Al.I. Cuza” University Iasi, 11 Carol I Bd, Iasi 700506, Romania
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/ Vasilichia Antocia
  • Department of Chemistry, “Al.I. Cuza” University Iasi, 11 Carol I Bd, Iasi 700506, Romania
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/ Ana Maria Zbanciocb
  • Corresponding author
  • “Gr.T. Popa” University of Medicine and Pharmacy, Iasi, School of Pharmacy, Str. Universitatii 16, 700115 Iasi, Romania
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Published Online: 2013-08-08 | DOI: https://doi.org/10.2478/achi-2013-0002

Abstract

We report herein a feasible study concerning design, syntheses and structure of some new diazolium salts with dihydroxyacetophenone skeleton of anticipated anticancer and antimicrobial activity. The syntheses of the desired imidazolium dihydroxyacetophenone salts occur smoothly, via an N-alkylation reaction, with good to excellent yields. The structure of the newly compounds were assigned without doubts by elemental and spectral analysis: IR, 1H NMR, 13C NMR, 2D-COSY, 2D-HETCOR (HMQC), long range 2D-HETCOR (HMBC).

Keywords: N-Alkylation; Imidazole; Dihydroxyacetophenone; Antibacterial; Anticancer

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About the article

Published Online: 2013-08-08

Published in Print: 2013-05-01


Citation Information: Acta Chemica Iasi, Volume 21, Issue 1, Pages 9–18, ISSN (Online) 2067-2446, DOI: https://doi.org/10.2478/achi-2013-0002.

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