Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Acta Pharmaceutica

The Journal of Croatian Pharmaceutical Society

4 Issues per year


IMPACT FACTOR 2016: 1.288
5-year IMPACT FACTOR: 1.600

CiteScore 2016: 1.55

SCImago Journal Rank (SJR) 2016: 0.353
Source Normalized Impact per Paper (SNIP) 2016: 0.854

Open Access
Online
ISSN
1846-9558
See all formats and pricing
More options …
Volume 57, Issue 2 (Jun 2007)

Issues

Hepatoprotective effect of the ethyl acetate extract of Teucrium polium L. against carbontetrachloride-induced hepatic injury in rats

Tatjana Panovska
  • Institute of Toxicology Faculty of Pharmacy, University »Ss. Cyril and Methodius«, 1000 Skopje, Republic of Macedonia
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Svetlana Kulevanova
  • Institute of Pharmacognosy Faculty of Pharmacy, University »Ss. Cyril and Methodius«, 1000 Skopje, Republic of Macedonia
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Icko Gjorgoski
  • Institute of Biology Faculty of Natural Sciences and Mathematics, University »Ss. Cyril and Methodius«, P. B. 126, 1000 Skopje Republic of Macedonia
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Mirjana Bogdanova / Gordana Petrushevska
  • Institute of Pathology, University »Ss. Cyril and Methodius«, 1000 Skopje, Republic of Macedonia
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2007-05-16 | DOI: https://doi.org/10.2478/v10007-007-0020-x

Hepatoprotective effect of the ethyl acetate extract of Teucrium polium L. against carbontetrachloride-induced hepatic injury in rats

Hepatoprotective activity of the ethyl acetate extract of Teucrium polium L. was investigated using rats with CCl4--induced liver damage. Specific biochemical parameters (glutathione peroxidase, superoxide dismutase, reduced glutathione and total antioxidative status) were estimated in blood and in liver homogenate. Lipid peroxidation in CCl4--intoxicated rats was evidenced by a marked increment in the levels of thiobarbituric acid reactive substances. Histopatological examinations of the liver were undertaken to monitor the liver status. Silymarin was used as a standard to compare the hepatoprotective activity of the extract. Some biochemical parameters in groups treated with the Teucrium polium extract at a dose of 25 mg kg-1, showed significantly different values than that of the CCl4--treated group. The liver biopsy of all experimental rat groups treated with the Teucrium polium ethyl acetate extract showed significant restoration of the normal histomorphological pattern of liver cells. The study substantiates the potential hepatoprotective activity of the ethyl acetate extract of Teucrium polium L.

Hepatoprotective effect of the ethyl acetate extract of Teucrium polium L. against carbontetrachloride-induced hepatic injury in rats

Hepatoprotektivno djelovanje etil-acetatnog ekstrakta biljke Teucrium polium L. ispitivano je na Štakorima čija je jetra oštećena tetraklormetanom. Specifični biokemijski parametri (glutation peroksidaza, superoksid dismutaza, reducirani glutation i ukupni antioksidativni status) procijenjeni su u krvi i homogenatu jetre. Lipidna peroksidacija u Štakora intoksiciranih tetraklormetanom dokazana je povećanjem koncentracije reaktivnih derivata tiobarbiturne kiseline. Stanje jetre procijenjeno je histopatološkim ispitivanjima. U ispitivanjima hepatoprotektivnog djelovanja ekstrakta Teucrium polium upotrebljen je silimarin kao standard. Neki biokemijski parametri u skupini životinja tretiranih ispitivanim ekstraktom u dozi od 25 mg kg-1 imali su značajno različite vrijednosti od skupine tretirane s CCl4. Biopsija jetre u svim ispitivanim životinjama tretiranim ekstraktom pokazala je uspostavu normalnih histomorfoloških uvjeta u stanicama, Što ukazuje na hepatoprotektivno djelovanje biljke Teucrium polium.

Keywords: Teucrium polium (Lamiaceae); hepatoprotective effect; carbon tetrachloride; sylimarin; glutathione

Keywords: Teucrium polium Lamiaceae; hepatoprotektivni učinak; tetraklormetan; silimarin; glutation

  • T. Sunita, V. Vupta and B. Sandeep, Comparative study of antioxidant potential of tea with and without additivies, Indian. J. Physiol. Pharmacol.44 (2000) 215-219.Google Scholar

  • B. Halliwell and J. M. C. Gutteridge, Free Radicals in Biology and Medicine, 2nd ed., Oxford University Press, Oxford 1989, pp. 78-93.Google Scholar

  • S. K. Mitra, M. V. Venkataranganna, R. Sudaram and S. Gopumadhavan, Protective effect of HD-03, a herbal formulation, against various hepatotoxic agents in rats, J. Ethnopharmacol.63 (1998) 181-186; DOI: 10.1016/S0378-8741(98)00088-9Google Scholar

  • B. Uday, D. Das and K. R. Banerjee, Reactive oxygen species: Oxidative damage and pathogenesis, Curr. Sci.77 (1999) 658-666.Google Scholar

  • C. Fraga, B. Leibovitz and A. Tappel, Halogenated compounds as inducers of lipid peroxidation in tissue slices, Free Rad. Biol. Med.3 (1987) 119-123.Google Scholar

  • P. Hochstein and A. S. Atallah, The nature of oxidants and antioxidant systems in the inhibition of mutation and cancer, Mutation Res.202 (1988) 363-375; DOI: 10.1016/0027-5107(88)90198-4.CrossrefGoogle Scholar

  • M. S. Suleiman, A. S. Abdul-Ghani, S. Al-Khalil and R. Amin, Effect of Teucrium polium boiled leaf extract on intestinal motility and blood pressure, J. Ethnopharmacol.22 (1988) 111-116; DOI: 10.1016/0378-8741(88)90236-X.CrossrefGoogle Scholar

  • M. Tariq, A. M. Ageel and M. S. Al-Said, Antiinflammatory activity of T. polium, Int. J. Tissue React.11 (1989) 185-188.Google Scholar

  • M. N. Gharaibeh, H. H. Elayan and A. S. Salhab, Hypoglycemic effects of Teucrium polium, J. Ethnopharmacol.24 (1988) 93-99; DOI: 10.1016/0378-8741(88)90139-0.CrossrefGoogle Scholar

  • Z. Yaniv, A. Dafni, J. Friedman and D. Palevitch, Plants used for the treatment of diabetes in Isreal, J. Ethnopharmacol.19 (1987) 145-151; DOI: 10.1016/0378-8741(87)90038-9.CrossrefGoogle Scholar

  • G. Autore, F. Capasso, R. De Fusco, M. P. Fasulo, M. Lembo, N. Mascolo and A. Menghini, Antipyretic and antibacterial actions of Teucrium polium (L.), Pharmacol. Res. Commun.16 (1984) 21-29; DOI: 10.1016/S0031-6989(84)80101-0.PubMedCrossrefGoogle Scholar

  • G. Ilhami, U. Metin, O. Munir, B. Suktru and K. Irfan, Antioxidant and antimicrobial activities of Teucrium polium L., J. Food Technol.1 (2003) 9-16.Google Scholar

  • T. Kadifkova Panovska, S. Kulevanova and M. Stefova, In vitro antioxidant activity of some Teucrium species (Lamiaceae), Acta Pharm.55 (2005) 207-214.Google Scholar

  • T. Kadifkova Panovska and S. Kulevanova, Effect of some Teucrium species (Lamiaceae) on lipid peroxidation in rat liver microsomes, Fresenius Environ. Bull.14 (2005) 957-959.Google Scholar

  • R. O. Recknagel, A new direction in the study of carbon tetrachloride hepatotoxicity, Life Sci.33 (1983) 401-408; DOI: 10.1016/0024-3205(83)90787-7.CrossrefGoogle Scholar

  • M. J. Ellenhorn, Ellenhorn's Medical Toxicology: Diagnosis and Treatment of Human Poisoning, 2nd ed., Williams and Wilkins Publications, Los Angeles 1997.Google Scholar

  • E. Beutler, O. Duron and B. M. Kelly, Improved method for the determination of blood glutathione, J. Lab. Clin. Med.61 (1963) 882-888.Google Scholar

  • H. Ohkawa, N. Ohishi and K. Yagi, Assay for lipid peroxides in animal tissue by thiobarbituric acid reaction, Anal. Biochem.95 (1979) 351-358; DOI: 10.1016/0003-2697(79)90738-3.PubMedCrossrefGoogle Scholar

  • M. M. Bradford, A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein dye binding, Anal. Biochem.72 (1976) 248-254; DOI: 10.1016/0003-2697(76)90527-3.CrossrefGoogle Scholar

  • A. Valenzuela, C. Lagos, K. Schmidt and K. Videla, Sylimarin protection against hepatic lipid peroxidation induced by acute ethanol intoxication in the rat, Biochem. Pharmacol.3 (1985) 2209-2212. DOI: 10.1016/0006-2952(85)90421-6.CrossrefGoogle Scholar

About the article


Published Online: 2007-05-16

Published in Print: 2007-06-01


Citation Information: Acta Pharmaceutica, ISSN (Online) 1846-9558, ISSN (Print) 1330-0075, DOI: https://doi.org/10.2478/v10007-007-0020-x.

Export Citation

This content is open access.

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Ruhollah Sayyad and Reza Farahmandfar
Journal of Food Science and Technology, 2017
[2]
Fatma Rahmouni, Mongi Saoudi, Nahed Amri, Abdelfattah El-Feki, Tarek Rebai, and Riadh Badraoui
Archives of Physiology and Biochemistry, 2017, Page 1
[3]
Rahim Amini, Razieh Yazdanparast, Safiyeh Aghazadeh, and Seyed H Ghaffari
Human & Experimental Toxicology, 2011, Volume 30, Number 9, Page 1303
[4]
Syed Muhammad Mukarram Shah, Abdul Sadiq, Syed Muhammad Hassan Shah, and Farhat Ullah
BMC Complementary and Alternative Medicine, 2014, Volume 14, Number 1
[5]
Nacera Baali, Zahia Belloum, Samiya Baali, Beatrice Chabi, Laurence Pessemesse, Gilles Fouret, Souad Ameddah, Fadila Benayache, Samir Benayache, Christine Feillet-Coudray, Gérard Cabello, and Chantal Wrutniak-Cabello
Nutrients, 2016, Volume 8, Number 4, Page 193
[6]
Sana Bakari, Marwa Ncir, Samir Felhi, Hafedh Hajlaoui, Mongi Saoudi, Neji Gharsallah, and Adel Kadri
Food Science and Biotechnology, 2015, Volume 24, Number 6, Page 1943
[7]
Abdulrahman K. Al-Asmari, Abdulrahman M. Al-Elaiwi, Md Tanwir Athar, Mohammad Tariq, Ahmed Al Eid, and Saeed M. Al-Asmary
Evidence-Based Complementary and Alternative Medicine, 2014, Volume 2014, Page 1
[8]
Nabyla Khaled-Khodja, Lila Boulekbache-Makhlouf, and Khodir Madani
Industrial Crops and Products, 2014, Volume 61, Page 41
[9]
Syed Muhammad Mukarram Shah, Farhat Ullah, Syed Muhammad Hassan Shah, Mohammad Zahoor, and Abdul Sadiq
BMC Complementary and Alternative Medicine, 2012, Volume 12, Number 1
[10]
Mohamed Ben Sghaier, Mounira Krifa, Rim Mensi, Wissem Bhouri, Kamel Ghedira, and Leila Chekir-Ghedira
Journal of Immunotoxicology, 2011, Volume 8, Number 4, Page 288
[11]
Esmaeil Darabpour, Hossein Motamedi, and Seyyed Mansour Seyyed Nejad
Asian Pacific Journal of Tropical Medicine, 2010, Volume 3, Number 2, Page 124
[12]
A Dhiman
Journal of Chinese Integrative Medicine, 2012, Volume 10, Number 2, Page 117
[13]
Seifollah Bahramikia and Razieh Yazdanparast
Phytotherapy Research, 2012, Volume 26, Number 11, Page 1581
[14]
Safiyeh Aghazadeh and Razieh Yazdanparast
Clinical Nutrition, 2010, Volume 29, Number 3, Page 381
[16]
Eric Yarnell and Kathy Abascal
Alternative and Complementary Therapies, 2010, Volume 16, Number 1, Page 15
[17]
S.M. Seyyedneja and H. Motamedi
International Journal of Pharmacology, 2010, Volume 6, Number 5, Page 551

Comments (0)

Please log in or register to comment.
Log in