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Acta Pharmaceutica

The Journal of Croatian Pharmaceutical Society

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Volume 57, Issue 3 (Sep 2007)

Issues

Design, development and evaluation of novel nanoemulsion formulations for transdermal potential of celecoxib

Sanjula Baboota
  • Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), New Delhi-110062, India
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Faiyaz Shakeel
  • Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), New Delhi-110062, India
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  • De Gruyter OnlineGoogle Scholar
/ Alka Ahuja
  • Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), New Delhi-110062, India
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/ Javed Ali
  • Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), New Delhi-110062, India
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  • De Gruyter OnlineGoogle Scholar
/ Sheikh Shafiq
  • Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), New Delhi-110062, India
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2007-09-18 | DOI: https://doi.org/10.2478/v10007-007-0025-5

Design, development and evaluation of novel nanoemulsion formulations for transdermal potential of celecoxib

The aim of the present study was to investigate the potential of nanoemulsion formulations for transdermal delivery of celecoxib (CXB). The in vitro skin permeation profile of optimized formulations was compared with CXB gel and nanoemulsion gel. Significant increase in the steady state flux (Jss), permeability coefficient (Kp) and enhancement ratio (Er) was observed in nanoemulsion formulations T1 and T2 (p < 0.05). The highest value of these permeability parameters was obtained in formulation T2, which consisted of 2% (m/m) of CXB, 10% (m/m) of oil phase (Sefsol 218 and Triacetin), 50% (m/m) of surfactant mixture (Tween-80 and Transcutol-P) and 40% (m/m) water. The anti-inflammatory effects of formulation T2 showed a significant increase (p < 0.05) in inhibition after 24 h compared to CXB gel and nanoemulsion gel on carrageenan-induced paw edema in rats. These results suggested that nanoemulsions are potential vehicles for improved transdermal delivery of CXB.

Dizajn, razvoj i vrednovanje novih nanoemulzija za transdermalnu primjenu celekoksiba

U radu su opisana ispitivanja nanoemulzija za transdermalnu primjenu celekoksiba (CXB). Profil permeacije kroz kožu ispitivan je in vitro i uspoređivan sa CXB gelom i nanoemulzijskim gelom. U formulacijama T1 i T2 postignuto je značajno povećanje ustaljenog fluksa (Jss), koeficijenta permeabilnosti (Kp) i povećanje omjera (Er) (p < 0.05). Najveće vrijednosti parametara permeabilnosti dobivene su u formulaciji T2 koja je sadržala 2% m/m CXB, 10% m/m uljne faze (Sefsol 218 i Triacetin), 50% m/m površinski-aktivnih tvari (Tween-80 i Transcutol-P) i 40% m/m vode. Protuupalno djelovanje formulacije T2 na edem šape štakora uzrokovan karageninom značajno je povećano (p < 0.05) poslije 24 h u usporedbi sa CXB gelom i nanoemulzijskim gelom. Rezultati ukazuju na poboljšanu isporuku celekoksiba putem nanoemulzija.

Keywords: celecoxib; nanoemulsions; microemulsions; nanoemulsion gels; transdermal delivery; anti-inflammatory effect

Keywords: celekoksib; nanoemulzije; mikroemulzije; nanoemulzijksi gel; transdermalna primjena; protuupalno djelovanje

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About the article


Published Online: 2007-09-18

Published in Print: 2007-09-01


Citation Information: Acta Pharmaceutica, ISSN (Online) 1846-9558, ISSN (Print) 1330-0075, DOI: https://doi.org/10.2478/v10007-007-0025-5.

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