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Acta Pharmaceutica

The Journal of Croatian Pharmaceutical Society

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1846-9558
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Volume 59, Issue 3 (Sep 2009)

Issues

Metalloantibiotics: Synthesis, characterization and antimicrobial evaluation of bismuth-fluoroquinolone complexes against Helicobacter pylori

Anwar Shaikh
  • Pharmacy Department, Faculty of Technology and Engineering, The M. S. University of Baroda, Vadodara-390001, India
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Rajani Giridhar
  • Pharmacy Department, Faculty of Technology and Engineering, The M. S. University of Baroda, Vadodara-390001, India
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Francis Megraud
  • Laboratoire de Bacteriologie, Université Victor Segalen Bordeaux 2 and Hôpital Pellegrin, Place Amélie Raba-Léon 33076 Bordeaux cedex France
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Mange Yadav
  • Pharmacy Department, Faculty of Technology and Engineering, The M. S. University of Baroda, Vadodara-390001, India
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  • De Gruyter OnlineGoogle Scholar
Published Online: 2009-10-09 | DOI: https://doi.org/10.2478/v10007-009-0027-6

Metalloantibiotics: Synthesis, characterization and antimicrobial evaluation of bismuth-fluoroquinolone complexes against Helicobacter pylori

Novel organometallic compounds have been prepared by complexing the fluoroquinolones, norfloxacin, ofloxacin, ciprofloxacin, sparfloxacin, lomefloxacin, pefloxacin and gatifloxacin, with bismuth. The complexes were characterized by UV, IR, atomic absorption spectroscopy, elemental analysis, differential scanning calorimetry, thermogravimetric analysis and mass spectrometry. Their antibacterial potential against Helicobacter pylori and other microorganisms was investigated. These compounds were found to possess strong activity against Helicobacter pylori with a minimum inhibitory concentration of 0.5 mg L-1. They also exhibited moderate activity against Escherichia coli, Staphylococcus aureus, Bacillus pumilus and Staphylococcus epidermidis. These bismuth-fluoroquinolone complexes have the potential to be developed as drugs against H. pylori related ailments.

Metaloantibiotici: Sinteza, karakterizacija i antimikrobno djelovanje kompleksa fluorokinolona s bizmutom na Helicobacter pylori

Komplesacijom fluorokinolona, norfloksacina, ofloksacina, ciprofloksacina, sparfloksacina, lomefloksacina, pefloksacina i gatifloksacina s bizmutom pripravljeni su novi organometalni spojevi. Dobiveni kompleksi karakterizirani su UV, IR i atomskom apsorpcijskom spektroskopijom, elementarnom analizom, diferencijalnom pretražnom kalorimetrijom, termogravimetrijskom analizom i spektrometrijom masa. Nadalje, ispitivan je njihov učinak na Helicobacter pylori i druge mikroorganizme. Ispitivani spojevi pokazuju snažno djelovanje na Helicobacter pylori u koncentraciji 0,5 mg L-1 te umjereno djelovanje na Escherichia coli, Staphylococcus aureus, Bacillus pumilus i Staphylococcus epidermidis. Kompleksi fluorokinolona s bizmutom potencijalni su lijekovi za infekcije uzrokovane H. pylori.

Keywords: fluoroquinolone; bismuth; complex; antimicrobial activity; Helicobacter pylori

Keywords: fluorokinolon; bizmut; kompleks; antimikrobno djelovanje; Helicobacter pylory

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About the article


Published Online: 2009-10-09

Published in Print: 2009-09-01


Citation Information: Acta Pharmaceutica, ISSN (Online) 1846-9558, ISSN (Print) 1330-0075, DOI: https://doi.org/10.2478/v10007-009-0027-6.

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