Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Acta Pharmaceutica

The Journal of Croatian Pharmaceutical Society

4 Issues per year


IMPACT FACTOR 2016: 1.288
5-year IMPACT FACTOR: 1.600

CiteScore 2016: 1.55

SCImago Journal Rank (SJR) 2016: 0.353
Source Normalized Impact per Paper (SNIP) 2016: 0.854

Open Access
Online
ISSN
1846-9558
See all formats and pricing
More options …
Volume 61, Issue 1

Issues

Simultaneous spectrophotometric determination of valsartan and hydrochlorothiazide by H-point standard addition method and partial least squares regression

Karunanidhi Lakshmi
  • Department of Pharmaceutical Analysis, SRM College of Pharmacy, SRM University, Kattankulathur-603 203, India
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Sivasubramanian Lakshmi
  • Department of Pharmaceutical Analysis, SRM College of Pharmacy, SRM University, Kattankulathur-603 203, India
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2011-03-15 | DOI: https://doi.org/10.2478/v10007-011-0007-5

Simultaneous spectrophotometric determination of valsartan and hydrochlorothiazide by H-point standard addition method and partial least squares regression

Simultaneous determination of valsartan and hydrochlorothiazide by the H-point standard additions method (HPSAM) and partial least squares (PLS) calibration is described. Absorbances at a pair of wavelengths, 216 and 228 nm, were monitored with the addition of standard solutions of valsartan. Results of applying HPSAM showed that valsartan and hydrochlorothiazide can be determined simultaneously at concentration ratios varying from 20:1 to 1:15 in a mixed sample. The proposed PLS method does not require chemical separation and spectral graphical procedures for quantitative resolution of mixtures containing the titled compounds. The calibration model was based on absorption spectra in the 200-350 nm range for 25 different mixtures of valsartan and hydrochlorothiazide. Calibration matrices contained 0.5-3 μg mL-1 of both valsartan and hydrochlorothiazide. The standard error of prediction (SEP) for valsartan and hydrochlorothiazide was 0.020 and 0.038 μg mL-1, respectively. Both proposed methods were successfully applied to the determination of valsartan and hydrochlorothiazide in several synthetic and real matrix samples.

Simultano spektrofotometrijsko određivanje valsartana i hidroklorotiazida metodom H-točke standardne adicije i djelomičnom regresijom najmanjih kvadrata

U radu je opisano simultano određivanje valsartana i hidroklorotiazida metodom H-točke standardne adicije (HPSAM) i djelomičnom kalibracijom najmanjih kvadrata (PLS). Praćene su apsorbancije na dvije valne duljine, 216 i 228 nm, nakon dodatka standardne otopine valsartana. Rezultati primjene HPSAM pokazali su da se valsartan i hidroklorotiazid dadu odrediti simultano ako je omjer njihovih koncentracija u smjesi od 20:1 do 1:15. Za potpunu rezoluciju smjesa navedenih ljekovitih tvari preporučena PLS metoda ne treba niti kemijsko odjeljivanje niti grafičku obradu. Kalibracija se temelji na apsorpciji pri valnim duljinama 200-350 nm provedenoj na 25 različitih smjesa valsartana i hidroklorotiazida. Koncentracije valsartana i hidroklorotiazida u kalibracijskim matricama bile su 0.5-3 μg mL-1. Očekivane standardne greške (SEP) za valsartan i hidroklorotiazid iznosile su 0,020, odnosno 0,038 μg mL-1. Obje predložene metode uspješno su primijenjene za određivanje valsartana i hidroklorotiazida u nekoliko sintetskih i realnih uzoraka.

Keywords: valsartan; hydrochlorothiazide; H-point standard addition method; partial least squares regression; multicomponent analysis

Keywords: valsartan; hidroklorotiazid; metoda H-točke standardne adicije; djelomična regresija najmanjih kvadrata; višekomponentna analiza

  • H. Siragy, Angiotensin II receptor blockers: review of the binding characteristics, Am. J. Cardiol. 84 (1999) 3S-8S; DOI: 10.1016/2FS0002-9149/2899/2900727-4.CrossrefGoogle Scholar

  • E. Francotte, A. Davatz and P. Richert, Development and validation of chiral HPLC methods for the quantitation of valsartan and of the tosylate of valine benzyl ester, J. Chromatogr. B. Biomed. Appl. 686 (1996) 77-83; DOI: 10.1016/2FS0378-4347/2896/2900242-3.CrossrefGoogle Scholar

  • A. Sioufi, F. Morfil and J. Godbillon, Automated determination of an angiotensin II receptor antagonist in plasma by high performance liquid chromatography, J. Liq. Chromatogr. 17 (1994) 2179-2186; DOI: 10.1080/2F10826079408013539.CrossrefGoogle Scholar

  • H. H. Maurer, T. Kraemer and J. W. Arlt, Screening for the detection of angiotensin converting enzyme inhibitors, their metabolites and AT II receptor antagonists, Ther. Drug Monit. 20 (1998) 706-713; DOI: 10.1097/2F00007691-199812000-00022.CrossrefGoogle Scholar

  • E. Satana, S. Altinay, N. G. Goger, S. A. Ozkan and Z. Senturk, Simultaneous determination of valsartan and hydrochlorothiazide by first derivative ultraviolet spectrophotometry and LC, J. Pharm. Biomed. Anal. 25 (2001) 1009-1013; DOI: 10.1016/2FS0731-7085/2801/2900394-6.CrossrefGoogle Scholar

  • H. Li, Y. Wang, Y. Jiang, Y. Tang, J. Wang, L. Zhao and J. Gu, A LC/MS method for the simultaneous quantification of valsartan and hydrochlorothiazide in human plasma, J. Chromatogr. B 852 (2007) 436-442; DOI: 10.1016/2Fj.jchromb.2007.02.014.CrossrefGoogle Scholar

  • I. E. Panderi and P. M. Parissi, Simultaneous determination of benazepril hydrochloride and hydrochlorothiazide by microbore liquid chromatography, J. Pharm. Biomed. Anal. 21 (1999) 1017-1024; DOI: 10.1016/2FS0731-7085/2899/2900195-8.CrossrefGoogle Scholar

  • D. Farthing, I. Fakhry, E. B. Ripley and D. Sica, Simple method for determination of hydrochlorothiazide in human urine by HPLC utilizing narrow bore chromatography, J. Pharm. Biomed. Anal. 17 (1998) 1455-1459; DOI: 10.1016/2FS0731-7085/2898/2900021-1.CrossrefGoogle Scholar

  • K. Richter, R. Oerter and W. Kirch, New sensitive method for the determination of hydrochlorothiazide in human serum by high performance liquid chromatography with electrochemical detection, J. Chromatogr. A 729 (1996) 293-296; DOI: 10.1016/2F0021-9673/2895/2900900-0.CrossrefGoogle Scholar

  • D. L. Hertzog, J. F. McCafferty, X. Fang, R. J. Tyrrell and R. A. Reed, Development and validation of a stability indicating HPLC method for the simultaneous determination of losartan potassium, hydrochlorothiazide and their degradation products, J. Pharm. Biomed. Anal. 30 (2002) 747-760; DOI: 10.1016/2FS0731-7085/2802/2900385-0.CrossrefGoogle Scholar

  • M. Kartal and N. Erk, Simultaneous determination of hydrochlorothiazide and amiloride hydrochloride by ratio spectra derivative spectrophotometry and high performance liquid chromatography, J. Pharm. Biomed. Anal. 19 (1999) 477-485; DOI: 10.1016/2FS0731-7085/2898/2900241-6.CrossrefGoogle Scholar

  • F. A. El-Yazbi, H. H. Abdine and R. A. Shaalan, Simultaneous determination of amiloride HCl, hydrochlorothiazide and atenolol in combined formulations by derivative spectroscopy, J. Pharm. Biomed. Anal. 17 (1998) 877-884; DOI: 10.1016/2FS0731-7085/2897/2900241-0.CrossrefGoogle Scholar

  • I. E. Panderi, Simultaneous determination of benezapril hydrochloride and hydrochlorothiazide in tablets by second order derivative spectrophotometry, J. Pharm. Biomed. Anal. 21 (1999) 257-265; DOI: 10.1016/2FS0731-7085/2899/2900134-X.CrossrefGoogle Scholar

  • A. Fattah, M. El Walily, S. F. Belal, E. A. Heaba and A. El-Kersh, Simultaneous determination of enelapril maleate and hydrochlorothiazide by first derivative ultraviolet spectrophotometry and high performance liquid chromatography, J. Pharm. Biomed. Anal. 13 (1995) 851-856; DOI: 10.1016/2F0731-7085/2895/2901346-M.CrossrefGoogle Scholar

  • K. Beliz, E. Dinc and D. Baleanu, Chemometric methods for the simultaneous spectrophotometric determination of telmisartan and hydrochlorothiazide in the commercial pharmaceuticals, Rev. Chim. 60 (2009) 544-560.Google Scholar

  • A. El-Gindy, S. Emara and H. Shaaban, Development and validation of chemometrics assisted spectrophotometric and liquid chromatographic methods for the simultaneous determination of two multicomponent mixtures containing bronchodilator drugs, J. Pharm. Biomed. Anal. 43 (2007) 973-982; DOI: 10.1016/2Fj.jpba.2006.09.020.Web of ScienceCrossrefGoogle Scholar

  • M. D. Luca, F. Oliverio, G. Ioele and G. Ragno, Multivariate calibration techniques applied to derivative spectroscopy data for the analysis of pharmaceutical mixtures, Chemom. Intell. Lab. Syst. 96 (2009) 14-21; DOI: 10.1016/2Fj.chemolab.2008.10.009.CrossrefWeb of ScienceGoogle Scholar

  • J. M. L. Gallego and J. P. Arroyo, Spectrophotometric resolution of ternary mixtures of dexamethasone, polymyxin B and trimethoprim in synthetic and pharmaceutical formulations, Anal. Chim. Acta 437 (2001) 247-257; DOI: 10.1016/2FS0003-2670/2801/2901008-X.CrossrefGoogle Scholar

  • M. Blanco, J. Coello, F. Gonzalez, H. Iturriaga, S. Marpoch and X. Tomas, Spectrophotometric determination of pharmaceutical dosages by partial least squares calibration, J. Pharm. Biomed. Anal. 12 (1994) 509-514; DOI: 10.1016/2F0731-7085/2893/29E0004-7.CrossrefGoogle Scholar

  • G. Bagherian, M. Arab Chamjangali and H. Eskandari, Simultaneous determination of cobalt and palladium in micellar medium using H-point standard addition method and partial least square regression, Spectrochim. Acta A 67 (2007) 378-384; DOI: 10.1016/2Fj.saa.2006.07.026.CrossrefGoogle Scholar

About the article


Published Online: 2011-03-15

Published in Print: 2011-03-01


Citation Information: Acta Pharmaceutica, Volume 61, Issue 1, Pages 37–50, ISSN (Online) 1846-9558, ISSN (Print) 1330-0075, DOI: https://doi.org/10.2478/v10007-011-0007-5.

Export Citation

This content is open access.

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[2]
Amal Mahmoud Abou Al Alamein, Lobna Abd El Aziz Hussien, and Ekram Hany Mohamed
Bulletin of Faculty of Pharmacy, Cairo University, 2015, Volume 53, Number 2, Page 173
[3]
Samya M. El-Gizawy, Osama H. Abdelmageed, Mahmoud A. Omar, Sayed M. Deryea, and Ahmed M. Abdel-Megied
American Journal of Analytical Chemistry, 2012, Volume 03, Number 06, Page 422
[4]
Ana Paula Pires Eisele, Guilherme Roberto Mansano, Fernanda Midori de Oliveira, Juliana Casarin, César Ricardo Teixeira Tarley, and Elen Romão Sartori
Journal of Electroanalytical Chemistry, 2014, Volume 732, Page 46
[5]
Mahmoud Mohamed Issa, R'afat Mahmoud Nejem, Alaa Abu Shanab, and Raluca-Ioana Stefan-van Staden
International Journal of Spectroscopy, 2013, Volume 2013, Page 1
[7]
Rasha A. Shaalan, Tarek S. Belal, Fawzy A. El Yazbi, and Sohila M. Elonsy
Arabian Journal of Chemistry, 2017, Volume 10, Page S1381
[8]

Comments (0)

Please log in or register to comment.
Log in