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Acta Pharmaceutica

The Journal of Croatian Pharmaceutical Society

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Volume 63, Issue 3


Drug interactions with statins

Anida Causevic-Ramosevac
  • Corresponding author
  • Bosnalijek, Pharmaceutical and Chemical Industry, Joint Stock Company, arajevo Bosnia and Herzegovina
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Sabina Semiz
  • Faculty of Pharmacy University of Sarajevo, Sarajevo Bosnia and Herzegovina
  • Faculty of Engineering and Natural Sciences, International University of Sarajevo, Sarajevo Bosnia and Herzegovina
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2013-10-22 | DOI: https://doi.org/10.2478/acph-2013-0022


The 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) are generally well tolerated as monotherapy. Statins are associated with two important adverse effects, asymptomatic elevation in liver enzymes and myopathy. Myopathy is most likely to occur when statins are administered with other drugs. Statins are substrates of multiple drug transporters (including OAT- -P1B1, BCRP and MDR1) and several cytochrome P450 (CYP) enzymes (including CYP3A4, CYP2C8, CYP2C19, and CYP2C9). Possible adverse effects of statins can occur due to interactions in concomitant use of drugs that substantially inhibit or induce their methabolic pathway. This review summarizes the most important interactions of statins.

Keywords: statins; drug interactions; cytochrome P450 (CYP) enzymes; drug transporters; adverse effects

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About the article

Published Online: 2013-10-22

Published in Print: 2013-09-01

Citation Information: Acta Pharmaceutica, Volume 63, Issue 3, Pages 277–293, ISSN (Online) 1846-9558, ISSN (Print) 1330-0075, DOI: https://doi.org/10.2478/acph-2013-0022.

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