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Acta Pharmaceutica

The Journal of Croatian Pharmaceutical Society

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IMPACT FACTOR 2016: 1.288
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ISSN
1846-9558
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Volume 63, Issue 3

Issues

Quantification of ascorbic acid and sodium ascorbate in powder blends for tableting and in vitamin C chewable tablets by NIR-chemometry

Ioan Tomuţă
  • Corresponding author
  • Iuliu Hatieganu University of Medicine and Pharmacy, Department of Pharmaceutical Technology and Biopharmaceutics, 400023 Cluj-Napoca Romania
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  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Dana Dudaş
  • Iuliu Hatieganu University of Medicine and Pharmacy, Department of Pharmaceutical Technology and Biopharmaceutics, 400023 Cluj-Napoca Romania
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Andreea Loredana Vonica / Sorin E. Leucuţa
  • Iuliu Hatieganu University of Medicine and Pharmacy, Department of Pharmaceutical Technology and Biopharmaceutics, 400023 Cluj-Napoca Romania
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2013-10-22 | DOI: https://doi.org/10.2478/acph-2013-0029

Abstract

The paper proposes a near infrared method able to directly and simultaneously quantify ascorbic acid and sodium ascorbate in powder blends for tableting and in vitamin C chewable tablets without any sample preparation. In the first step, calibration models for the quantification of ascorbic acid and sodium ascorbate in powder blends for tableting and subsequently in chewable vitamin C tablets (corresponding to 80-120 % active substance) were developed according to an experimental design with 2 variables and 5 levels. Then, using the best calibration models, the methods were fully validated in terms of recovery, precision and accuracy for both powder blends and vitamin C chewable tablets. The validated concentration range was 15.14-18.51 % for ascorbic acid and 12.06-14.49 % for sodium ascorbate in powder blends and 91.85-111.03 mg per tablet for ascorbic acid and 71.01-84.50 mg per tablet for sodium ascorbate in tablets. Validation results showed good precision and accuracy.

Keywords: NIR spectroscopy; chemometrics; ascorbic acid; sodium ascorbate; validation; powder blends

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About the article

Published Online: 2013-10-22

Published in Print: 2013-09-01


Citation Information: Acta Pharmaceutica, Volume 63, Issue 3, Pages 373–384, ISSN (Online) 1846-9558, ISSN (Print) 1330-0075, DOI: https://doi.org/10.2478/acph-2013-0029.

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