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Acta Pharmaceutica

The Journal of Croatian Pharmaceutical Society

4 Issues per year

IMPACT FACTOR 2016: 1.288
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CiteScore 2016: 1.55

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Volume 65, Issue 1


Formulation and characterization of solid lipid nanoparticles, nanostructured lipid carriers and nanoemulsion of lornoxicam for transdermal delivery

Ümit Gönüllü
  • Istanbul University Faculty of Pharmacy Department of Pharmaceutical Technology, Istanbul, Turkey
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Melike Üner
  • Corresponding author
  • Istanbul University Faculty of Pharmacy Department of Pharmaceutical Technology, Istanbul, Turkey
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Gülgün Yener
  • Istanbul University Faculty of Pharmacy Department of Pharmaceutical Technology, Istanbul, Turkey
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Ecem Fatma Karaman
  • Istanbul University Faculty of Pharmacy Department of Pharmaceutical Technology, Istanbul, Turkey
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Zeynep Aydoğmuş
Published Online: 2015-03-11 | DOI: https://doi.org/10.1515/acph-2015-0009


Solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC) and nanoemulsion (NE) of lornoxicam (LRX) were prepared for the treatment of painful and inflammatory conditions of the skin. Compritol® 888 ATO, Lanette® O and oleic acid were used as solid and liquid lipids. SLN, NLC and NE were found physically stable at various temperatures for 6 months. Case I diffusional drug release was detected as the dominant mechanism indicating Fickian drug diffusion from nanoparticles and nanoemulsion. The highest rate of drug penetration through rat skin was obtained with NE followed by NLC, SLN and a gel formulation. Nanoformulations significantly increased drug penetration through rat skin compared to the gel (p < 0.05). Thus, SLN, NLC and NE of LRX can be suggested for relieving painful and inflammatory conditions of the skin

Keywords: lornoxicam; solid lipid nanoparticles; nanostructured lipid carriers; nanoemulsion; transdermal delivery; inflammation


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About the article

Received: 2014-10-23

Published Online: 2015-03-11

Published in Print: 2015-03-01

Citation Information: Acta Pharmaceutica, Volume 65, Issue 1, Pages 1–13, ISSN (Online) 1846-9558, DOI: https://doi.org/10.1515/acph-2015-0009.

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© by Melike Üner. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

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