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Acta Pharmaceutica

The Journal of Croatian Pharmaceutical Society

4 Issues per year


IMPACT FACTOR 2016: 1.288
5-year IMPACT FACTOR: 1.600

CiteScore 2016: 1.55

SCImago Journal Rank (SJR) 2016: 0.353
Source Normalized Impact per Paper (SNIP) 2016: 0.854

Open Access
Online
ISSN
1846-9558
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Volume 66, Issue 2 (Jun 2016)

Issues

Release of selected amino acids from zinc carriers

Renata Dyja
  • Corresponding author
  • Department of Applied, Pharmacy and Drug Technology, Medical University of Silesia, 41-200 Sosnowiec, Poland
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Barbara Dolińska
  • Department of Applied, Pharmacy and Drug Technology, Medical University of Silesia, 41-200 Sosnowiec, Poland
  • Pharmaceutical Research and Product Plant »Biochefa«, 41-200 Sosnowiec, Poland
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Florian Ryszka
Published Online: 2016-05-28 | DOI: https://doi.org/10.1515/acph-2016-0024

Abstract

The paper deals with the results of an investigation of the release of selected amino acids (histidine, tryptophan, tyrosine) from model suspensions prepared by co-precipitation with zinc chloride. It has been proven that the influence of the Zn(II)/amino acid molar ratio on dissolution profiles of the tested amino acids and dissolution half-life (t1/2) of histidine or tryptophan is significant. The amount of amino acid in the dispersed phase (supporting dose) is a determinant of the amino acid release profile. There is a minimal supporting dose (30.0 μmol of histidine or 17.4 μmol of tryptophan) that provides release of similar amounts of amino acid (4.1–4.6 μmol of histidine or 8.7–9.9 μmol of tryptophan) after the same time intervals. The tyrosine release profiles follow first order kinetics since the supporting dose (0.9–11.2 μmol) is limited by the tyrosine low solubility in water.

Keywords: amino acids; zinc; suspensions; dissolution; kinetics

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About the article

Accepted: 2016-02-16

Published Online: 2016-05-28

Published in Print: 2016-06-01


Citation Information: Acta Pharmaceutica, ISSN (Online) 1846-9558, DOI: https://doi.org/10.1515/acph-2016-0024.

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© 2016 Renata Dyja et al., published by De Gruyter Open. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

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