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Acta Pharmaceutica

The Journal of Croatian Pharmaceutical Society

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IMPACT FACTOR 2016: 1.288
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CiteScore 2016: 1.55

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Volume 67, Issue 2


Influence of concentration and type of microcrystalline cellulose on the physical properties of tablets containing Cornelian cherry fruits

Aleš Franc
  • Department of Pharmaceutics University of Veterinary and Pharmaceutical Sciences, 612 42 Brno, Czech Republic
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Slavomir Kurhajec
  • Department of Pharmaceutics University of Veterinary and Pharmaceutical Sciences, 612 42 Brno, Czech Republic
  • Department of Pharmacognosy and Botany, University of Veterinary Medicine and Pharmacy, 041 81 Košice, Slovakia
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Sylvie Pavloková
  • Department of Pharmaceutics University of Veterinary and Pharmaceutical Sciences, 612 42 Brno, Czech Republic
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Dana Sabadková
  • Corresponding author
  • Department of Pharmaceutics University of Veterinary and Pharmaceutical Sciences, 612 42 Brno, Czech Republic
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Jan Muselík
  • Department of Pharmaceutics University of Veterinary and Pharmaceutical Sciences, 612 42 Brno, Czech Republic
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2017-06-01 | DOI: https://doi.org/10.1515/acph-2017-0019


The aim of this study was to find the optimal tablet composition with maximum content of dried fruits (Cornus mas L.). The effect of three different concentrations (12.5, 25 and 50 %) of two types of microcrystalline cellulose (Avicel® PH 101 and Avicel® PH 200) and three different compression pressures (20, 60 and 100 MPa) on the physical properties of tablet blends and tablets was studied. Tablets containing 50 % Avicel® PH 101 compressed under 100 MPa were found to have the best physical properties. This combination of composition and compression pressure resulted in stable tablets even after storage under accelerated stability conditions (6 months, 40 °C and 75 % RH).

Keywords: Cornus mas; microcrystalline cellulose; direct compression; accelerated stability; principal component analysis


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About the article

Accepted: 2016-02-21

Published Online: 2017-06-01

Published in Print: 2017-06-27

Citation Information: Acta Pharmaceutica, Volume 67, Issue 2, Pages 187–202, ISSN (Online) 1846-9558, DOI: https://doi.org/10.1515/acph-2017-0019.

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© by Dana Sabadková. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License. BY-NC-ND 4.0

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