Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Acta Chimica Slovaca

The Journal of Slovak University of Technology in Bratislava

2 Issues per year

Open Access
Online
ISSN
1337-978X
See all formats and pricing
More options …

Current problems in the use of organic UV filters to protect skin from excessive sun exposure

Zuzana Klimová
  • Corresponding author
  • Institute of Biotechnology and Food Science, Faculty of Chemical and Food Technology, Slovak University of Technology, Radlinského 9, 812 37 Bratislava, Slovak Republic
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Jarmila Hojerová
  • Institute of Biotechnology and Food Science, Faculty of Chemical and Food Technology, Slovak University of Technology, Radlinského 9, 812 37 Bratislava, Slovak Republic
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Silvia Pažoureková
  • Institute of Biotechnology and Food Science, Faculty of Chemical and Food Technology, Slovak University of Technology, Radlinského 9, 812 37 Bratislava, Slovak Republic
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2013-05-22 | DOI: https://doi.org/10.2478/acs-2013-0014

Abstract

The evidences of the harmful effects of skin exposure to excessive UltraViolet (UV) radiation, primarily on the development of skin cancer, have increased over the last decade. Therefore, national and international health authorities have encouraged the public to take protective sunscreens, and respectively also everyday cosmetics containing UV filters. In these products, a mixture of the UV filters, including both inorganic and organic nature, has been shown to be more effective than the individual UV filter. However, currently there are concerns about the safety and actual effectiveness of some UV filters; especially about certain UV-absorbing compounds (organic UV filters). Three cardinal problems are the most questionable. First, that certain UV filters are absorbed through the skin resulting in systemic exposure with unknown consequences. Second, that certain UV filters show the potential to be adversely endocrine disruptors. Third, that certain UV filters are partially degraded by UV radiation, what making them photounstable and unable to fulfil their basic protective function. The purpose of this article is to discuss these problems.

Keywords: sunscreens; organic UV filters; endocrine disruptors; dermal absorption; photostability; safety

  • Bonda CA, Steinberg DC (2000) Cos. Toil. 115: 37-45.Google Scholar

  • Cambon M, Castell D, Robert C (2001) Int. J. Cosmet. Sci. 52: 1-11.Google Scholar

  • Carou ME, Deguiz ML, Reynoso R, Szwarcfarb B, Carbone S, Meguilevsky JA, Scacchi P, Ponzo OJ (2009) Environ. Toxicol. Pharmacol. 27: 410-414.Google Scholar

  • COLIPA, 2006. COLIPA Guidelines: International Sun Protection Factor (SPF) test method, 46 p.Google Scholar

  • Couteau C, Faure A, Fortin J, Paparis E, Coiffard LJM (2007) J. Pharm. Biomed. Anal. 44: 270-273.Google Scholar

  • Couteau C, El-Boury S, Paparis E, Sebille-Rivain V, Coiffard LJM (2009) Pharm. Dev. Technol. 14: 369-372.Google Scholar

  • Damiani E, Baschong W, Greci L (2007) J. Photochem. Photobiol. B. 87: 95-104.Google Scholar

  • Diffey BL, Tanner PR, Matts PJ, Nash JF (2000) J. Am. Acad. Dermatol. 43: 1024-1035.Google Scholar

  • Dondi D, Albini A, Serpone N (2006) Photochem. Photobiol. Sci. 5: 835-843.Google Scholar

  • Durand L, Habran N, Henschel V, Amighi K (2008) Int. J. Cosmet. Sci. 31: 279-292.Google Scholar

  • EC (2006) European Commission. Of. J. Eur. Comm. L 265/39: 1-5.Google Scholar

  • EC (2009) European Commission. Of. J. Eur. Comm. L 342/59: 59-209.Google Scholar

  • FDA (2011) U.S. Food and Drug Administration. Federal Register 76: 35678-35681.Google Scholar

  • Felix T, Hall BJ, Brodbelt JS (1998) Anal. Chim. Acta. 371: 195-203.Google Scholar

  • Gaspar LRM, Campos PMBG (2007) Int. J. Pharm. 343: 181-189.Google Scholar

  • Giokas DL, Amparo S, Chisvert A (2007) Trends Anal. Chem. 26: 360-374.Google Scholar

  • Gonzalez H, Farbort A, Larko O, Wennberg AM (2006) Br. J. Dermatol. 154: 337-340.Google Scholar

  • Guldson B, Wong H, Korsch M, Gomez L, Casey P, McCall M, McCulloch M, Trotter J, Stauber J, Greenoak G (2012) Sci. Total Environ. 420: 313-318.Google Scholar

  • Hany J, Nagel R (1995) Dtsch. Lebensm. Rundsch. 91: 341-345.Google Scholar

  • Herzog B, Wehrle M, Quass K (2009) Photochem. Photobiol. 85: 869-878.Google Scholar

  • Herzog B, Mongiat S, Deshayes C, Neuhaus M, Sommer K, Mantler A (2000) Int. J. Cosmetic. Sci. 24: 170-185.Google Scholar

  • Hojerova J, Šovčikova D, Mikula M (2006) J. Pol. Soc. Cosmet. Chem. 9: 11-16.Google Scholar

  • Hojerova J, Medovčikova A, Mikula M (2007) J. Pol. Soc. Cosmet. Chem. 9: 191-197.Google Scholar

  • Hojerova J, Boskovičova E (2009). Kozmetika-zdraviekrasa (in Slovak). MetroMedia, Bratislava, pp. 354.Google Scholar

  • Hojerova J, Medovčikova A, Mikula M (2011) Int. J. Pharm. 408: 27-38.Google Scholar

  • Chisvert A, Leon-Gonzalez Z, Tarazona I, Salvador A, Giokas D (2012) Anal. Chim. Acta 752: 11-29.Google Scholar

  • Janjua NR, Mogensen B, Andersson AM, Petersen JH, Henriksen M, Skakkebaek NE, Wulf HC (2004) J. Invest. Dermatol. 123: 57-61.Google Scholar

  • Klocker J, Oelgemoller M, Robertson S, Glass BD (2012) J. Photochem. Photobiol. 13: 91-110.Google Scholar

  • Kunisue T, Chen Z, Louis GMB, Sundaram R, Hediger M, Sun L, Kannan K (2012) Environ. Sci. Technol. 46: 4624-4632.PubMedGoogle Scholar

  • Loden M, Beitner H, Gonzalez H, Edstrom DW, Akerstrom U, Austad J, Buraczewska-Norin I, Matsson M, Wulf HC (2011) Br. J. Dermatol. 165: 255-260.Google Scholar

  • Ma RS, Cotton B, Lichtensteiger W, Schlumpf M (2003) Toxicol. Sci. 74: 43-50.Google Scholar

  • Maier H, Schauberger G., Brunnhofer K, Honigsmann H (2001) J. Invest. Dermatol. 117: 256-262. Google Scholar

  • Maier H, Schauberger G, Martincigh BS, Brunnhofer K, Honigsmann H (2005) Photodermatol. Photoimmunol. Photomed. 21: 84-92.Google Scholar

  • Marrot L, Belaidi JP, Lejeune F, Meunier JR, Asselineau D, Bernerd F (2004) Br. J. Dermatol. 151: 1234-1244.Google Scholar

  • Moyal DD, Fourtanier, AM (2008) J. Am. Acad. Dermatol. 58: 149-154.Google Scholar

  • Nashev LG, Schuster D, Laggner Ch, Sodha S, Langer T, Wolber G, Odermatt A (2010) Biochem. Pharmacol. 79: 1189-1199.Google Scholar

  • Osterwalder U, Herzog B (2010) Photochem. Photobiol. Sci. 9: 470-481.Google Scholar

  • Pescia AC, Astolfi P, Puglia C, Bonina F, Perrotta R, Herzog B, Damiani E (2012) Int. J. Pharm. 427: 217-223.Google Scholar

  • SCCS (2012) E.U. Scientific Committee on Consumer Safety. SCCS/1501/12: 1-133.Google Scholar

  • Scalia S, Mezzena M, Ramaccini D (2011) Skin. Pharmacol. Physiol. 24: 182-189.Google Scholar

  • Scalia S, Mezzena M, Bianchi, A (2010) Int. J. Cosmet. Sci. 32: 55-64.Google Scholar

  • Serpone N, Salinaro A, Emeline V, Horikoshi S, Hidaka H, Zhao JC (2002) Photochem. Photobiol. Sci. 1: 970-981.Google Scholar

  • Schlumpf M, Cotton B, Conscience M, Haller V, Steinmann B, Lichtensteiger W (2001) Environ. Health. Perspect. 109: 239-244.Google Scholar

  • Schlumpf M, Kypke K, Birchler M, Durrer S et al. (2008) Chimie 62: 345-351.Google Scholar

  • Schreurs R, Sonneveld E, Jansen JHJ, van der Burg B (2005) Toxicol. Sci. 83: 264-272.Google Scholar

  • Schreurs R, Lanser P, Seinen W, van der Burg B (2002) Arch. Toxicol. 76: 257-261.Google Scholar

  • Stanfield J, Osterwalder U, Herzog B (2010) Photochem. Photobiol. Sci. 9: 489-494.Google Scholar

  • Stokes R, Diffey BL (1999) Int. J. Cosmet. Sci. 21: 241-251.Google Scholar

  • Tarras-Wahlberg N, Stenhagen G, Larko O, Rosen A, Wennberg AM, Wennerstrom OJ (1999) Invest. Dermatol. 113: 547-553.Google Scholar

  • Toutiou E, Godin B (2008) Cl. Dermatol. 26: 375-379.Google Scholar

  • Venditti E, Spadoni T, Tiano L, Astolfi P, Greci L, Littarru GP, Damiani E (2008) Free Radical Biol. Med. 45: 345-354.Google Scholar

  • WHO (2006) Environmental Health Criteria 235: Dermal Absorption. World Health Organization Press, Geneva, pp. 197.Google Scholar

About the article

Published Online: 2013-05-22

Published in Print: 2013-04-01


Citation Information: Acta Chimica Slovaca, ISSN (Print) 1337-978X, DOI: https://doi.org/10.2478/acs-2013-0014.

Export Citation

This content is open access.

Comments (0)

Please log in or register to comment.
Log in