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Acta Chimica Slovaca

The Journal of Slovak University of Technology in Bratislava

2 Issues per year

Open Access
Online
ISSN
1337-978X
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Therapeutic potential of curcumin in medicinal chemistry

Daniela Košťálová
  • Department of Nutrition and Food Assessment, Faculty of Chemical and Food Technology, Radlinského 9, 812 37 Bratislava
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/ Lýdia Bezáková
  • Department of Cell and Molecular Biology of Drugs, Faculty of Pharmacy, Comenius University, Odbojárov 10, 832 32 Bratislava
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/ Lucia Račkovác
  • Institute of Experimental Pharmacology and Toxicology, Slovak Academy of Sciences, Dúbravská cesta 9, 841 04 Bratislava
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/ Silvia Mošovská
  • Corresponding author
  • Department of Nutrition and Food Assessment, Faculty of Chemical and Food Technology, Radlinského 9, 812 37 Bratislava
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/ Ernest Šturdík
  • Department of Nutrition and Food Assessment, Faculty of Chemical and Food Technology, Radlinského 9, 812 37 Bratislava
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Published Online: 2013-05-22 | DOI: https://doi.org/10.2478/acs-2013-0015

Abstract

Extensive research over the past half century has shown that curcumin (diferuloylmethane), a polyphenolic compound of turmeric (Curcuma longa L.), can modulate multiple cell signaling pathways. Extensive clinical trials have addressed the pharmacokinetics, safety, and efficacy of this nutraceutical against numerous diseases in human. Curcumin, known for thousand years as a subject of Ayurvedic medicine, has undergone in recent times remarkable transformation into a drug candidate with prospective multipotent therapeutic application. Characterized by high chemical reactivity, resulting from an extended conjugated double bond system prone to nucleophilic attack, curcumin has been shown to interact with a plethora of molecular targets, in numerous experimental observations. In clinical trials, has been used either alone or in combination with other agent. However, its clinical advance has been limited by its short biological half-life, fast metabolism and poor systemic bioavailability after oral administration. To mitigate the above limitations, recently various formulation of curcumin, including nanoparticles, micelles, liposomes, phytosomes delivery system has been examined. The present review has been devoted towards better understanding of the phytonutraceutic properties of curcumin and turmeric based on their disease specific indications and enhancing their prophylactic and therapeutic nutraceutical qualities. The article deals with the biological activity, mode of action, toxicity and forthcoming application of these leads.

Keywords: curcumin; turmeric; absorption; bioavailability; metabolism; nanocurcumin; medicine

About the article

Published Online: 2013-05-22

Published in Print: 2013-04-01


Citation Information: Acta Chimica Slovaca, ISSN (Print) 1337-978X, DOI: https://doi.org/10.2478/acs-2013-0015.

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