Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Acta Veterinaria

The Journal of University of Belgrade

4 Issues per year


CiteScore 2016: 0.65

SCImago Journal Rank (SJR) 2016: 0.388
Source Normalized Impact per Paper (SNIP) 2016: 0.605

Open Access
Online
ISSN
1820-7448
See all formats and pricing
More options …

Genotype and allele frequencies of polymorphisms in ABCG2, PPARGC1A and OLR1 genes in indigenous cattle breeds in Turkey

Atila Ateş
  • Department of Biochemistry, Faculty of Veterinary Medicine, University of Istanbul, Avcılar, Istanbul, Turkey
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Gülhan Türkay Hoştürk
  • Department of Biochemistry, Faculty of Veterinary Medicine, University of Istanbul, Avcılar, Istanbul, Turkey
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Iraz Akiş
  • Department of Biochemistry, Faculty of Veterinary Medicine, University of Istanbul, Avcılar, Istanbul, Turkey
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Feraye Esen Gürsel
  • Department of Biochemistry, Faculty of Veterinary Medicine, University of Istanbul, Avcılar, Istanbul, Turkey
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Hasret Yardibi
  • Corresponding author
  • Department of Biochemistry, Faculty of Veterinary Medicine, University of Istanbul, Avcılar, Istanbul, Turkey
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Kemal Öztabak
  • Department of Biochemistry, Faculty of Veterinary Medicine, University of Istanbul, Avcılar, Istanbul, Turkey
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2014-03-25 | DOI: https://doi.org/10.2478/acve-2014-0008

Abstract

This study was carried out to determine polymorphisms of four genes in South Anatolian Red (SAR) and East Anatolian Red (EAR) indigenous cattle breeds in Turkey. Single nucleotide polymorphisms (SNPs) monitored in this study are Y581S in ATP binding cassette sub family G member 2 (ABCG2) gene, c.1892T>C and c.3359A>C in peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PPARGC1A) gene and g.8232C>A in oxidized low-density lipoprotein receptor 1 (OLR1) gene. The frequency of the ancestral allele A of the ABCG2 gene Y581S polymorphism was found to be very high (SAR: 0.63; EAR: 0.64) in both cattle breeds. The CC genotypes of PPARGC1A gene c.1892T>C (SAR: 0.65; EAR: 0.80) and OLR1 gene g.8232C>A polymorphisms (SAR: 0.82; EAR: 0.86), which are associated with high milk fat percentage, had higher frequencies than those of the other genotypes. In conclusion, we might suggest that the allele distribution of the ABCG2 gene Y581S polymorphism can be the evidence indicating autosomal gene flow from zebu cattle to SAR and EAR cattle breeds.

Keywords: ABCG2 gene; East Anatolian Red; gene polymorphism; OLR1 gene; PPARGC1A gene; South Anatolian Red

References

  • 1. Farke C, Mayer HH, Bruckmaier RM, Albrecht C: Differential expression of ABC transporters and their regulatory genes during lactation and dry period in bovine mammary tissue. J Dairy Sci 2008, 75:406-414.Web of ScienceGoogle Scholar

  • 2. Van Herwaarden AE, Wagenaar E, Merino G, Jonker JW, Rosing H, Beijnen JH, Schinkel AH: Multidrug transporter ABCG2/breast cancer resistance protein secretes ribofl avin (vitamin B2) into milk. Mol Cell Biol 2007, 27:1247-1253.CrossrefGoogle Scholar

  • 3. Cohen-Zinder M, Seroussi E, Larkin DM, Loor JJ, Everts-van der Wind A, Lee JH: Identifi cation of a missense mutation in the bovine ABCG2 gene with a major effect on the QTL on chromosome 6 affecting milk yield and composition in Holstein cattle. Genome Res 2005, 15:936-944.CrossrefGoogle Scholar

  • 4. Puigserver P: Tissue-spesifi c regulation of metabolic pathways trough the transcriptional coactivator PGC1-alpha. Int J Obes 2005, 29:5-9.CrossrefGoogle Scholar

  • 5. Linang H, Ward WF: PGC-1alpha: a key regulator of energy metabolism. Adv Physiol Educ 2006, 30:145-151.CrossrefGoogle Scholar

  • 6. Weikard R, Kühn C, Goldammer T, Freyer G, Schwerin M: The bovine PPARGC1A gene: molecular characterization and association of an SNP with variation of milk fat synthesis. Physiol Genomics, 2005, 21:1-13CrossrefGoogle Scholar

  • 7. Khatip H, Zaitoun I, Wiebelhaus-Finger J, Chang YM, Rosa GJM: The association of bovine PPARGC1A and OPN genes with milk composition in two independent Holstein cattle populations. J Dairy Sci 2007, 90:2966-2970.Web of ScienceCrossrefGoogle Scholar

  • 8. Komisarek J, Dorynek Z: Effect of ABCG2, PPARGC1A, OLR1 and SCD1 gene polymorphism on estimated breeding values for functional and production traits in polish Holstein-Friesian bulls. J Appl Genet 2009, 50:125-132.Web of ScienceCrossrefGoogle Scholar

  • 9. Metha JL, Li D: Identifi cation, regulation and function of a novel lectin-like oxidized lowdensity lipoprotein receptor. J Am Coll Cardiol 2002, 39:1429-1435.Google Scholar

  • 10. Khatip H, Leonard SD, Schutzkus V, Luo W, Chang YM: Association of the OLR1 gene with milk composition in Holstein dairy cattle. J Dairy Sci 2006, 89:1753-1760.CrossrefGoogle Scholar

  • 11. Miller M, Dykes DD, Polesky HF: A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 1985, 16:1215-1219.Google Scholar

  • 12. Yeh, F, Yang RC, Boyle T: Popgene (v. 1.32): Microsoft Windows-based freeware for Population Genetic Analysis. [http://www.ualberta.ca/~fyeh/popgene_download.html]Google Scholar

  • 13. Khatkar MS, Thomson PC, Imke T, Herman WR: QTL mapping in dairy cattle: review and meta-analysis. Genet Sel Evol 2004, 36:163-190.CrossrefPubMedGoogle Scholar

  • 14. Ron M, Cohen-Zinder, M, Peter C, Weller JI, Erhardt GA: Polymorphism in ABCG2 in Bos indicus and Bos taurus cattle breeds. J Dairy Sci 2006, 89:4921-4923.CrossrefGoogle Scholar

  • 15. Tantia MS, Vijh RK, Mishra BP, Mishra B, Kumar B, Sodhi M: DGAT I and ABCG2 polymorphism in Indian cattle (Bos indicus) and Buffalo (Bubalus bubalis) breeds. BMC Vet Res 2006, 2:1-5.Google Scholar

  • 16. Akis I, Oztabak K: Bos indicus associated alleles in Anatolian cattle breeds support zebu introgression into Near East. J Biol Res -Thessalon 2013, 19:131-138.Google Scholar

  • 17. Edwards CJ, Baird JF, MacHugh DE: Taurine and Zebu admixture in Near Eastern cattle: A comparison of mitochondrial, autosomal and Y-chromosomal data. Anim Genet 2007, 38:520-524.Web of ScienceCrossrefGoogle Scholar

  • 18. Alim MA, Fan Y, Xie Y, Xiaoping W, Sun D, Zhang Y, Zhang S, Zhang Y, Zhang Q, Liu L: Single nucleotide polymorphism (SNP) in PPARGC1A gene associates milk production traits in Chinese Holstein Cattle. Pak Vet J 2012, 32:609-612.Google Scholar

  • 19. Komisarek J, Walendowska A: Analysis of the PPARGC1A gene as a potantial marker for productive and reproduktive traits in cattle. Folia Biol-Karakow 2012, 60:171-174.CrossrefGoogle Scholar

  • 20. Kowalewska-Luczak I, Kulig H, Kmiec M: Associations between the bovine PPARGC1A gene and milk production traits. Czech J Anim Sci 2010, 55:195-199.Google Scholar

  • 21. Schennink A, Bovenhuis H, Leon-Koosterziel KM, van Arendonk, JAM, Visker MHPW: Effect of polymorphisms in the FASN, OLR1, PPARGC1A, PRL and STAT5A genes on bovine milk-fat composition. Anim Genet 2009, 40:909-916. Google Scholar

About the article

Published Online: 2014-03-25

Published in Print: 2014-03-01


Citation Information: Acta Veterinaria, Volume 64, Issue 1, Pages 73–80, ISSN (Online) 1820-7448, DOI: https://doi.org/10.2478/acve-2014-0008.

Export Citation

This content is open access.

Comments (0)

Please log in or register to comment.
Log in