Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Acta Veterinaria

The Journal of University of Belgrade

4 Issues per year


CiteScore 2016: 0.65

SCImago Journal Rank (SJR) 2016: 0.388
Source Normalized Impact per Paper (SNIP) 2016: 0.605

Open Access
Online
ISSN
1820-7448
See all formats and pricing
More options …

Acute Phase Proteins as Markers of Infectious Diseases in small Animals / Proteini Akutne Faze Kao Markeri Infektivnih Bolesti Malih Životinja

Elizabeth Moreira dos Santos Schmidt
  • Corresponding author
  • Department of Veterinary Clinical Sciences, Faculty of Veterinary Medicine and Animal Science, – UNESP, campus Botucatu – SP, Brazil
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Peter David Eckersall
  • Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, Glasgow G61 1QH UK
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2015-06-23 | DOI: https://doi.org/10.1515/acve-2015-0013

Abstract

During the acute phase response, there is an increased production and release of certain proteins known as acute phase proteins (APPs) which can be produced by hepatocytes and peripheral tissues such as C-reactive protein (CRP), serum amyloid A (SAA), haptoglobin (Hp), alpha-1 acid glycoprotein (AGP). These proteins have been investigated as markers of various infectious diseases in small animals and the purpose of this review is to update the current knowledge about APPs in infectious diseases in dogs and cats.

Tokom odgovora akutne faze, postoji poveć ana proizvodnja i oslobađanje određenih proteina, poznatih kao proteini akutne faze (APP), koje mogu proizvesti hepatociti i periferna tkiva. Proteini akutne faze su C-reaktivni protein (CRP), serumski amiloid A (SAA), haptoglobin (Hp), alfa-1 kiseli glikoprotein (AGP). Ovi proteini su ispitivani kao markeri raznih infektivnih oboljenja pasa i mačaka. Svrha ovog rada je da se ažuriraju savremena saznanja o APP tokom zaraznih bolesti pasa i mačaka

Keywords : acute phase proteins; Haptoglobin; C-reactive protein; Serum amyloid A; dogs

References

  • 1. Eckersall PD, Bell R. Acute phase proteins: biomarkers of infection and infl ammation. Vet Journal 2010, 185:23-27.Google Scholar

  • 2. Murata H,Shimada N, Yoshioka M. Current research on acute phase proteins in veterinary diagnosis: an overview. Vet Journal 2004, 168:28-40.Google Scholar

  • 3. Cerón JJ, Eckersall PD, Martínez-Subiela S. Acute phase proteins in dogs and cats: current knowledge and future perspectives. Vet ClinPathol 2005, 34:85-99.Google Scholar

  • 4. Petersen HH, Nielsen JP, Heegaard PMH. Application of acute phase protein measurements in veterinary clinical chemistry. Vet Res 2004, 35:163-187.CrossrefPubMedGoogle Scholar

  • 5. Eckersall PD. Proteins, proteomics, and the dysproteinemias. In: Clinical biochemistry of domestic animals. San Diego, USA: Academic Press; 2008, 117-155.Google Scholar

  • 6. Kajikawa T, Furuta A, Onishi T, Tajima T, Sugii S. Changes in concentrations of serum amyloid A, alpha 1-acid glycoprotein, haptoglobin and C-reactive protein in feline sera due to induced inflammation and surgery. Vet ImmunolImmunopathol 1999, 68:91-98.Google Scholar

  • 7. Christensen MB, Langhorn R, Goddard A, Andreasen EB, Moldal E, Tvarijonaviciute A, Kirpenteijn J, Jakobsen S, Persson F, Kjelgaard-Hansen M. Canine serum amyloid A (SAA) measured by automated latex agglutination turbidimetry is useful for routine sensitive and specific detection of systemic inflammation in a general clinical setting. J Vet Med Sci 2013, 75:459-466.CrossrefGoogle Scholar

  • 8. Tamamoto T, Ohno K, Takahashi M, Nakashima K, Fujino Y, Tsujimoto H. Serum amyloid A as a prognostic marker in cats with various diseases. J Vet Diagn Invest 2013, 25:428-432.PubMedCrossrefGoogle Scholar

  • 9. Kjelgaard-Hansen M, Jacobsen S. Assay validation and diagnostic applications of major acute-phase protein testing in companion animals. Clin Lab Med 2011, 31:51-70.CrossrefGoogle Scholar

  • 10. Dabrowski R, Kostro K, Lisiecka U, Szczubial M, Krakowski L. Usefulness of C-reactive protein, serum amyloid A component, and haptoglobin determinations in bitches with pyometra for monitoring early post-ovariohysterectomy complications. Theriogenology 2009, 72:471-476.PubMedCrossrefGoogle Scholar

  • 11. Ceciliani F, Cerón JJ, Eckersall PD, Sauerwein H. Acute phase proteins in ruminants. Journal of Proteomics 2012, 75:4207-4231.CrossrefPubMedGoogle Scholar

  • 12. Martínez-Subiela S, Ginel PJ, Cerón JJ. Effects of different glucocorticoids treatments on serum acute phase proteins in dogs. Vet Rec 2004, 154:814-817.Google Scholar

  • 13. Levy AP, Asleh R, Blum S, Levy NS, Miller-Lotan R, Kalet-Litman S, Anbinder Y, lache O, Nakhoul FM, Asaf R, Farbstein D, Pollak M, Soloveichik YZ, Strauss M, Alsshiek J, Livshits A, Schwartz A, Awad H, Jad K, Goldenstein H. Haptoglobin: basic and clinical aspects. Antiox Redox Signal 2010, 12:293-304.Google Scholar

  • 14. Duthie S, Eckersall PD, Addie DD, Lawrence CE, Jarrett O. Value of alpha 1-acid glycoprotein in the diagnosis of feline infectious peritonitis. Vet Rec 1997, 141:299-303.Google Scholar

  • 15. Giordano A, Spagnolo V, Colombo A, Paltrinieri S. Changes in some acute phase protein and immunoglobulin concentrations in cats affected by feline infectious peritonitis or exposed to feline coronavirus infection. Vet J 2004, 167:38-44.Google Scholar

  • 16. Tvarijonaviciute A, Tecles F, Caldin M, Tasca S, Cerón JJ. Validation of spectrophotometric assays for serum paraoxonase type-1 measuremnet in dogs. Am J Vet Res 2012, 73:34-40.CrossrefGoogle Scholar

  • 17. McClure V, van Schoor M, Thompson PN, Kjelgaard-Hansen M, Goddard A. Evaluation of the use of serum C-reactive protein concentration to predict outcome in puppies infected with canine parvovirus. JAVMA 2013, 243:361-366.CrossrefGoogle Scholar

  • 18. Kocaturk M, Tvarijonaviciute A, Martínez-Subiela S, Tecles F, Eralp O, Yilmaz Z, Cerón JJ. Inflammatory and oxidative biomarkers of disease severity in dogs with parvoviral enteritis. J Small Anim Pract 2014, 56:1-6.Google Scholar

  • 19. Alayash AI. Haptoglobin: old protein with new functions. Clin Chim Acta 2011, 42:493-498. CrossrefGoogle Scholar

  • 20. Ulutas B, Bayramli G, Ulutas PA, Karagenc T. Serum concentration of some acute phase proteins in naturally occurring canine babesiosis: a preliminary study. Vet Clin Pathol 2005, 34:144-147.PubMedCrossrefGoogle Scholar

  • 21. Wicher KB, Fries E. Evolutionary aspects of hemoglobin scavengers. Antiox Redox Signal 2010, 12:249-259.Google Scholar

  • 22. Kocaturk M, Martinez S, Eralp O, Tvarijonaviciute A, Cerón JJ, Yilmaz Z. Prognostic value of serum acute phase proteins in dogs with parvoviral enteritis. J Small Anim Pract 2010, 51:478-483.PubMedCrossrefGoogle Scholar

  • 23. Sheahan D, Bell R, Mellanby RJ, Gow AG, Friend E, Heller J, bence LM, Eckersall PD. Acute phase protein concentrations in dogs with nasal disease. Vet Rec 2010, 167:895-899.Google Scholar

  • 24. Yamamoto S, Shida T, Honda M, Ashida Y, Rikihisa Y, Odakura M, Hayashi S, Nomura M, Isayama Y. Serum C-reactive protein and imune responses in dogs inoculated with Bordetella bronchiseptica (phase I cells). Vet Res Commun 1994a, 18:347-357.CrossrefGoogle Scholar

  • 25. Yamamoto S, Miyaji S, Ashida Y, Otabe K, Momotani E, Rikihisa Y. Preparation of anticanine serum amyloid A (SAA) serum and purifi cation of SAA from canine high-density lipoprotein. Vet Immunol Immunopathol 1994b, 41:41-53.CrossrefGoogle Scholar

  • 26. Caspi D, Snel WJJ, Batt RM, Bennett D, Rutteman GR, Hartman EG, Baltz ML, Gruys E, Pepys MB. C-reactive protein in dogs. Am J Vet Res 1987, 48:919-921.PubMedGoogle Scholar

  • 27. Mastrorilli C, Dondi F, Agnoli C, Turba ME, Vezzali E, Gentilini F. Clinicopathologic features and outcome predictors of Leptospira interrogans Australis serogroup infection in dogs: a retrospective study of 20 cases (2001-2004). J Vet Intern Med 2007, 21:3-10.Google Scholar

  • 28. Tvarijonaviciute A, Eralp O, Kocaturk M, Yilmaz Z, Cerón JJ. Adiponectin and IGF-1 are negative acute phase proteins in a dog model of acute endotoxaemia. Vet ImmunolImmunopathol 2011, 140:147-151.Google Scholar

  • 29. Dabrowski R, Kostro K, Szczubial M. Concentrations of C-reactive protein, serum amyloid A and haptoglobin in uterine arterial and peripheral blood in bitches with pyometra. Theriogenology 2013, 80:494-497.PubMedCrossrefGoogle Scholar

  • 30. Dabrowski R, Wawron W, Kostro K. Changes in CRP, SAA and haptoglobin produced in response to ovariohysterectomy in healthy bitches and those with pyometra. Theriogenology 2007, 67:321-327.CrossrefPubMedGoogle Scholar

  • 31. Jitpean S, Pettersson A, Hoglund OV, Holst BS, Olsson U, Hagman R. Increased concentrations of serum amyloid A in dogs with sepsis caused by pyometra. BMC Vet Res 2014a, 10:273-281.CrossrefPubMedGoogle Scholar

  • 32. Jitpean S, Holst BS, Hoglund OV, Pettersson A, Olsson U, Strage E, Sodersten F, Hagman R. Serum insulin-like growth factor-I, iron, C-reactive protein, and serum amyloid A for prediction of outcome in dogs with pyometra. Theriogenology 2014b, 82:43-48.PubMedCrossrefGoogle Scholar

  • 33. Hagman R. Serum alpha-1-acid glycoprotein concentrations in 26 dogs with pyometra. Vet Clin Pathol 2011, 40:52-59.CrossrefPubMedGoogle Scholar

  • 34. Fransson BA, Karlstam E, Bergstrom A, Lagerstedt AS, Park JS, Evans MA, Ragle CA. C-reactive protein in the differentiation of pyometra from cystic endometrial hyperplasia/ mucometra in dogs. J Am Anim Hosp Assoc 2004, 40:391-399.CrossrefPubMedGoogle Scholar

  • 35. Mylonakis ME, Cerón JJ, Leontides L, Siarkou VI, Martinez S, Tvarijonaviciute A, Koutinas AF, Harrus S. Serum acute phase proteins as clinical phase indicators and outcome predictors in naturally occurring canine monocytic ehrlichiosis. J Vet Intern Med 2011, 25:811-817.PubMedCrossrefGoogle Scholar

  • 36. Shimada T, Ishida Y, Shimizu M, Nomura M, Kawato K, Iguchi K, Jinbo T. Monitoring C-reactive protein in beagle dogs experimentally inoculated with Ehrlichia canis. Vet Res Commun 2002, 26:171-177. PubMedCrossrefGoogle Scholar

  • 37. Rikihisa Y, Yamamoto S, Kwak I, Iqbal Z, Kociba G, Mott J, Chichanasiriwithaya W. C-reative protein and alpha-1-acid glycoprotein levels in dogs infected with Ehrlichia canis. Journal of Clinical Microbiology 1994, 32:912-917.Google Scholar

  • 38. Baric Rafaj R, Kules J, Selanec J, Vrkic N, Zoyko V, Zupancic M, TrampusBakija A, Matijatko V, Crnogaj M, Mrljak V. Markers of coagulation activation, endothelial stimulation, and infl ammation in dogs with babesiosis. Vet Intern Med 2013, 27:1172-1178.CrossrefGoogle Scholar

  • 39. Koster LS, Van Schoor M, Goddard A, Thompson PN, Matjila PT, Kjelgaard-Hansen M. C-reactive protein in canine babesiosis caused by Babesia rossi and its association with outcome. J S Afr Vet Assoc 2009, 80:87-91.Google Scholar

  • 40. Ndung’u JM, Eckersall PD, Jennings FW. Elevation of the concentration of acute phase proteins in dogs infected with Trypanosoma brucei. Acta Tro 1991, 49:77-86.Google Scholar

  • 41. Martínez-Subiela S, Tecles F, Eckersall PD, Cerón JJ. Serum concentrations of acute phase proteins in dogs with leishmaniasis. Vet Rec 2002, 150:241-244.Google Scholar

  • 42. Martínez-Subiela S, Strauss-Ayali D, Cerón JJ, Baneth G. Acute phase protein response in experimental canine leishmaniasis. Vet Parasitol 2011, 180:197-202.Google Scholar

  • 43. Silvestrini P, Zoia A, Planellas M, Roura X, Pastor J, Cerón JJ, Caldin M. Iron status and C-reactive protein in canine leishmaniasis. J Small AnimPract 2014, 55:95-101.CrossrefGoogle Scholar

  • 44. Méndez JC, Carretón E, Martínez S, Tvarijonaviciute A, Cerón JJ, Montoya-Alonso JA. Acute phase response in dogs with Dirofi laria immitis. Vet Parasitol 2014, 204:420-425.Google Scholar

  • 45. Venco L, Bertazzolo W, Giordano G, and Paltrinieri S. Evaluation of C - reactive protein as a clinical biomarker in naturally heartworm infected dogs: a field study. Vet Parasitol 2014, 206:48-54.Google Scholar

  • 46. Carretón E, Morchón R, Simón F, Juste MC, Méndez JC, Montoya-Alonso JA. Cardiopulmonary and infl ammatory biomarkers in the assessment of the severity of canine dirofi lariosis. Vet Parasitol 2014, 206:43-47.Google Scholar

  • 47. Pazzi P, Goddard A, Kristensen AT, Dvir E. Evaluation of hemostatic abnormalities in canine spirocercosis and its association with systemic infl ammation. J Vet Intern Med 2014, 28:21-29.CrossrefGoogle Scholar

  • 48. Nivy R, Caldin M, Lavy E, Shaabon K, Segev G, Aroch I. Serum acute phase protein concentrations in dogs with spirocercosis and their association with esophageal neoplasia - a prospective cohort study. Vet Parasitol 2014, 203:153-159.PubMedCrossrefGoogle Scholar

  • 49. Mylonakis ME, Cerón JJ, Leontides L, Rallis TS, Koutinas AF. Serum acute phase proteins in dogs with symptomatic esophageal spirocercosis. Vet Parasitol 2012, 190:191-195.Google Scholar

  • 50. Mukorera V, Dvir E, van der Merwe LL, Goddard A. Serum C-reactive protein concentration in benign and malignant canine spirocercosis. J Vet Intern Med 2011, 25:963-966.CrossrefGoogle Scholar

  • 51. Martínez-Subiela S, Bernal LJ, Tvarijonaviciute A, Garcia-Martinez JD, Tecles F, Cerón JJ. Canine demodicosis: the relationship between response to treatment of generalised disease and markers for inflammation and oxidative status. Vet Dermatol 2014, 25:72-76.CrossrefGoogle Scholar

  • 52. Paltrinieri S, Giordano A, Tranquillo V, Guazzetti S. Critical assessment of the diagnostic value of feline alpha 1-acid glycoprotein for feline infectious peritonitis using the likelihood ratios approach. J Vet Diagn Invest 2007, 19:266-272.PubMedGoogle Scholar

  • 53. Giori L, Giordano A, Giudice C, Grieco V, Paltrinieri S. Performances of different diagnostic tests for feline infectious peritonitis in challenging clinical cases. J Small Anim Pract 2011, 52:152-157. CrossrefPubMedGoogle Scholar

  • 54. Tamamoto T, Ohno K, Ohmi A, Goto-Koshino Y, Tsujimoto H. Verification of measurement of the feline serum amyloid A (SAA) concentration by human SAA turbidimetric immunoassay and its clinical application. J Vet Med Sci 2008, 70:1247-1252.CrossrefPubMedGoogle Scholar

  • 55. Korman RM, Cerón JJ, Knowles TG, Barker EN, Eckersall PD, Tasker S. Acute phase response to Mycoplasma haemofelis and ‘Candidatus Mycoplasma haemominutum” infection in FIV-infected and non-FIV-infected cats. Vet J 2012, 193:433-438.Google Scholar

  • 56. Strom Holst B, Krook L, Englund S, Lagerstedt AS, Bolske G. Shedding of Chlamydiae in relation to titers of serum chlamydiae-specifi c antibodies and serum concentrations of two acute phase proteins in cats without conjunctivitis. Am J Vet Res 2011, 72:806-812.CrossrefGoogle Scholar

  • 57. Leal RO, Gil S, Sepúlveda N, McGahie D, Duarte A, Niza MM, Tavares L. Monitoring acute phase proteins in retrovírus infected cats undergoing feline interferon-ω therapy. J Small Anim Pract 2014, 55:39-45.PubMedCrossrefGoogle Scholar

  • 58. Eckersall PD, Schmidt EMS. The final hurdles for acute phase protein analysis in small animal practice. J Small Anim Pract 2014, 55:1-3.PubMedCrossrefGoogle Scholar

About the article

Received: 2015-02-12

Accepted: 2015-03-19

Published Online: 2015-06-23

Published in Print: 2015-06-01


Citation Information: Acta Veterinaria, Volume 65, Issue 2, Pages 149–161, ISSN (Online) 1820-7448, DOI: https://doi.org/10.1515/acve-2015-0013.

Export Citation

© by Elizabeth Moreira dos Santos Schmidt. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Zorana Milanović, Anja Ilić, Jelena Francuski Andrić, Vladimir Radonjić, Anđelo Beletić, and Milica Kovačević Filipović
Ticks and Tick-borne Diseases, 2017
[2]
Hasan Oğuz Gürbüz and Pınar Alkım Ulutaş
Acta Veterinaria, 2017, Volume 67, Number 1

Comments (0)

Please log in or register to comment.
Log in