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Addiction Genetics


Emerging Science

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2084-7688
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Gender Differences in Alcohol Metabolizing Hepatic Enzyme Genotypes in Korean Patients with Alcohol Dependence

Jin-Seong Lee / Sung-Gon Kim
  • Department of Psychiatry, Pusan National University Yangsan Hospital, Yangsan, Korea
  • Department of Psychiatry, School of Medicine, Pusan National University, Yangsan, Korea
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  • Other articles by this author:
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/ Sae-Heon Jang / Won-Tan Byun / In-Bok Hwang / Chang-Soo Kim / Seong-Yeon Kim / Hyun-Sook Lee / Young-Hui Yang / David W. Oslin
  • Department of Psychiatry, University of Pennsylvania, Philadelphia, PA and the Philadelphia VA Medical Center and VISN 4 MIRECC, USA
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Published Online: 2013-05-10 | DOI: https://doi.org/10.2478/addge-2013-0001

Abstract

There are a number of epidemiological studies concerning the gender differences in the genetic etiology of alcohol dependence (AD), with ADH2 and ALDH2 being strong candidates. The purpose of this study was to investigate gender differences in frequencies of ADH2 and ALDH2 genotypes in AD patients and in a normal control (NC) group of Koreans. Study subjects consisted of 228 AD patients (180 males, 48 females) and 138 NC (79 males, 59 females). For both male and female subjects, the frequency of the ADH2*1/1 genotype was significantly higher in AD patients compared to the NC group. However, the effect size of the ADH2*1/1 genotype on AD was much larger in females than in males. Furthermore, the ALDH2*1/1 genotype was positively associated with AD in male subjects but negatively associated with AD in female patients. Interestingly, AD in males was primarily determined by ALDH2 enzyme activity (92%), whereas female AD was primarily determined by ADH2 enzyme activity (60.4%). These results suggest that risk for the development of AD in males is mainly associated with the ALDH2*1/1 genotype, while in female patients, the ADH2*1/1 genotype was more highly associated with risk of AD. Overall, it is evident that gender differences associated with genetic risks for AD are present.

Keywords: Alcohol dependence; ADH2; ALDH2; Gender differences; Genetic risk

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About the article

Received: 2012-12-25

Accepted: 2013-03-18

Published Online: 2013-05-10


Citation Information: Addiction Genetics, Volume 1, Pages 12–18, ISSN (Online) 2084-7688, DOI: https://doi.org/10.2478/addge-2013-0001.

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©2012 by Versita. This content is open access.

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