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Addiction Genetics


Emerging Science

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2084-7688
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Molecular Genetic Testing in Pain and Addiction: Facts, Fiction and Clinical Utility

Kenneth Blum / Mary Hauser / James Fratantonio / Rajendra D. Badgaiyan
Published Online: 2015-08-28 | DOI: https://doi.org/10.1515/addge-2015-0001

Abstract

The Brain Reward Cascade (BRC) is an interaction of neurotransmitters and their respective genes to control the amount of dopamine released within the brain. Any variations within this pathway, whether genetic or environmental (epigenetic), may result in addictive behaviors as well as altered pain tolerance. While there are many studies claiming a genetic association with addiction and other behavioral infractions, defined as Reward Deficiency Syndrome (RDS), not all are scientifically accurate and in some case just wrong. Albeit our bias, we discuss herein the facts and fictions behind molecular genetic testing in RDS (including pain and addiction) and the significance behind the development of the Genetic Addiction Risk Score (GARSPREDX™), the first test to accurately predict one’s genetic risk for RDS.

Keywords : Reward Deficiency Syndrome; Brain Reward Cascade; DRD2; Gene variations; Genetic Addiction Risk Score

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About the article


Published Online: 2015-08-28


Citation Information: Addiction Genetics, Volume 2, Issue 1, ISSN (Online) 2084-7688, DOI: https://doi.org/10.1515/addge-2015-0001.

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©2015 Kenneth Blum, et al.. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

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