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Acta Facultatis Medicae Naissensis

The Journal of Faculty of Medicine in Nis

4 Issues per year

Cite Score 2016: 0.25

SCImago Journal Rank (SJR) 2015: 0.109
Source Normalized Impact per Paper (SNIP) 2015: 0.124

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Antidiabetic and Antioxidant Activities of Ethanolic Extract of Dried Flowers of Moringa oleifera in Streptozotocin-induced Diabetic Rats

Rotimi Olusanya Arise / Oluwaseun Ruth Aburo
  • Department of Biochemistry, University of Ilorin, P.M.B. 1515, Ilorin, Nigeria Nigeria
  • Department of Biochemistry, Afe Babalola University, Ado Ekiti, Ekiti, Nigeria
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Samuel Tobi Farohunbi / Adenike Adebola Adewale
  • Department of Biochemistry, University of Ilorin, P.M.B. 1515, Ilorin, Nigeria Nigeria
  • Department of Biochemistry, Bowen University, Iwo, Osun State, Nigeria
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2016-12-22 | DOI: https://doi.org/10.1515/afmnai-2016-0028


This study was undertaken to determine the antidiabetic and antioxidant effects of oral administration of ethanolic extract of Moringa oleiferaflower on stretozotocin-induced diabetic rats at 100, 200, and 300 mg/kg b.w.

Thirty (30) male experimental albino rats were grouped randomly into six groups: groups A, B, and F are the control, diabetic control and reference drug groups, while C-E received 100, 200, and 300mg/kg b.w of the extract, respectively. Blood samples and organs were collected to assay for blood glucose level and antioxidant enzymes.

Levels of blood glucose, serum lipids and lipid peroxidation as well as aspartate aminotransferase (AST), alkaline phosphatase (ALP), and alanine aminotransferase (ALT) activities were significantly reduced (p<0.05) in STZ-induced diabetic rats orally administered ethanolic extract of M. oleifera flower. However, the body weight; catalase and superoxide dismutase activities were significantly increased (p < 0.05) when compared with the controls.

M. oleifera flower ethanolic extract administered orally therefore exhibited improved lipid metabolism, glucose-lowering potential and is hence beneficial in preventing diabetic complications as a result of lipid peroxidation and oxidative systems in streptozotocin-induced diabetic rats. It could thus be employed therapeutically in managing diabetes mellitus.

Keywords: ethanolic extract; antidiabetic; antioxidant enzymes; Moringa oleifera; streptozotocin


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About the article

Published Online: 2016-12-22

Published in Print: 2016-12-01

Citation Information: Acta Facultatis Medicae Naissensis, Volume 33, Issue 4, Pages 259–272, ISSN (Online) 2217-2521, DOI: https://doi.org/10.1515/afmnai-2016-0028.

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