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European Pharmaceutical Journal

Acta Facultatis Pharmaceuticae Universitatis Comenianae (formerly)

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CiteScore 2016: 0.28

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2453-6725
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Acute Pain Treatment at Department of Traumatology

B. Kováčová
  • Corresponding author
  • Comenius University in Bratislava, Faculty of Pharmacy, Department of Pharmacology and Toxicology, Odbojárov 10, 832 32, Bratislava, Slovak Republic
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  • De Gruyter OnlineGoogle Scholar
/ T. Foltánová
  • Comenius University in Bratislava, Faculty of Pharmacy, Department of Pharmacology and Toxicology
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/ Š. Kónya / A. Ďurišová
Published Online: 2012-12-28 | DOI: https://doi.org/10.2478/v10219-012-0021-9

Abstract

The aim of this retrospective study was to characterize the acute pain management in patients admitted to Department of Traumatology and to identify the efficacy of analgesic pharmacotherapy. The study involved 83 patients divided into two groups: 52 patients (63%) in Group 1 underwent operation; the remaining 31 patients (37%) in Group 2 had conservative treatment. The characteristics of the patients (diagnosis, analgesic therapy, age, comorbidities, drugs used during hospitalisation, analgesic efficacy) were obtained from electronic database and medical reports by the hospital. Therapy during the first seven days of hospitalisation and the recommended therapy after discharging home were analysed. Records of drug adverse reactions during the whole hospitalisation were monitored. Metamizol was the most frequently prescribed as a primal analgesic. Adequate analgesia solely by metamizol was reached in 20% of all patients; the remaining 80% required increased doses or combination with another analgesic. Metamizol was combined mainly with tramadol, morphine or pethidine. Our study proved metamizol to be an effective analgesic. No clinical manifestation of agranulocytosis was observed in this study.

Cieľom tejto retrospektívnej štúdie bolo charakterizovať zvládanie akútnej bolesti u hospitalizovaných pacientov na oddelení traumatológie a identifikovať úspešnosť analgetickej farmakoterapie. Sledovaný súbor tvorilo 83 pacientov, z toho 52 pacientov (63 %) podstúpilo operáciu a 31 pacientov (37 %) bolo ošetrených konzervatívne. Charakteristiky pacientov (príčina hospitalizácie, analgetická terapia, vek, komorbidity, súčasne užívané liečivá, reakcia na analgetickú liečbu) sme získali z elektronickej databázy a chorobopisov nemocnice. Analyzovali sme terapiu počas prvých 7 dní hospitalizácie a odporúčanú terapiu do domáceho ošetrenia po ukončení hospitalizácie. Záznamy o výskyte nežiaducich reakcií sme sledovali počas celej doby hospitalizácie pacientov. Najčastejšie primárne ordinovaným analgetikom bol metamizol. Dostatočná analgézia podľa základnej ordinácie výlučne (v monoterapii) metamizolom sa dosiahla u 20 % zo všetkých pacientov, 80 % pacientov si vyžadovalo zvýšenie dávky alebo kombináciu s iným analgetikom. Metamizol sa najčastejšie kombinoval s tramadolom, morfínom alebo petidínom. V našej štúdii sa metamizol ukázal ako účinné analgetikum. Zároveň sme nezaznamenali výskyt klinických prejavov agranulocytózy.

Keywords: acute pain; traumatology; metamizol; analgesic; hospitalisation

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Published Online: 2012-12-28


Citation Information: Acta Facultatis Pharmaceuticae Universitatis Comenianae, ISSN (Print) 0301-2298, DOI: https://doi.org/10.2478/v10219-012-0021-9.

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