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European Pharmaceutical Journal

Acta Facultatis Pharmaceuticae Universitatis Comenianae (formerly)

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CiteScore 2016: 0.28

SCImago Journal Rank (SJR) 2015: 0.195
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2453-6725
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Solubilisation of (+)-Usnic Acid in Aqueous Micellar Solutions of Gemini and Heterogemini Surfactants and their Equimolar Mixture

M. Lukáč
  • Corresponding author
  • Comenius University in Bratislava, Faculty of Pharmacy, Department of Chemical Theory of Drugs, Kalinčiakova 8, 832 32, Bratislava, Slovak Republic
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/ I. Prokipčák
  • Comenius University in Bratislava, Faculty of Pharmacy, Department of Chemical Theory of Drugs
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/ I. Lacko
  • Comenius University in Bratislava, Faculty of Pharmacy, Department of Chemical Theory of Drugs
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/ F. Devínsky
  • Comenius University in Bratislava, Faculty of Pharmacy, Department of Chemical Theory of Drugs
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Published Online: 2012-12-28 | DOI: https://doi.org/10.2478/v10219-012-0022-8

Abstract

The solubilisation of natural compound, (+)-usnic acid, in micellar solutions of gemini (N,N’-didecyl-N,N,N’,N’-tetramethylethane-1,2-diyldiammonium dibromide) and heterogemini (decyl 2-[decyl(dimethyl)ammonio]ethylphosphate) surfactants and their equimolar mixture has been studied. The highest solubility was found for gemini surfactant. The relationship between synergism in surface properties of mixture of surfactants and their solubilisation properties is also discussed.

Bola študovana solubilizacia prirodnej zlučeniny, kyseliny (+)-usnovej, v micelarnych roztokoch gemini (N,N’-didecyl-N,N,N’,N’-tetrametyletan-1,2-diyldiamoniumdibromid) a heterogemini (decyl 2-[decyl(dimetyl)ammonio]etylfosfat) tenzidov a ich ekvimolarnej zmesi. Najvyššia rozpustnosť bola zaznamenana v pripade gemini tenzidu. Diskutuje sa aj vzťah medzi synergizmom povrchovych vlastnosti zmesi tenzidov a ich solubilizačnymi vlastnosťami.

Keywords : gemini surfactant; heterogemini surfactant; usnic acid; solubilisation; solubilityin aqueous solutions

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About the article

Published Online: 2012-12-28


Citation Information: Acta Facultatis Pharmaceuticae Universitatis Comenianae, ISSN (Print) 0301-2298, DOI: https://doi.org/10.2478/v10219-012-0022-8.

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