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European Pharmaceutical Journal

Acta Facultatis Pharmaceuticae Universitatis Comenianae (formerly)

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2453-6725
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Synthesis and enantioseparation of derivatives of propranolol

R. Čižmáriková
  • Faculty of Pharmacy, Department of Chemical Theory of Drugs, Comenius University in Bratislava
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ S. Chudáčiková
  • Faculty of Pharmacy, Department of Chemical Theory of Drugs, Comenius University in Bratislava
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ J. Valentová
  • Faculty of Pharmacy, Department of Chemical Theory of Drugs, Comenius University in Bratislava
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ A. Némethy
  • Faculty of Pharmacy, Department of Chemical Theory of Drugs, Comenius University in Bratislava
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  • De Gruyter OnlineGoogle Scholar
Published Online: 2012-08-13 | DOI: https://doi.org/10.2478/v10219-012-0012-x

Synthesis and enantioseparation of derivatives of propranolol

Propranolol is one of the first prepared and in therapeutic praxis used beta- adrenolytics. In this paper novel derivatives of propranolol with cyclohexylamino and pyrrolidin-1-yl groups in hydrophilic part were prepared. HPLC-enantioseparation propranolol (as reference compound) and of the prepared derivatives has been achieved using a Chiralpak AD CSP based on the amylose tris (3,5-dimethylphenylcarbamate).(R)-enantiomer of the propranolol was prepared by stereoselective synthesis using Jacobsen catalyst.

Syntéza a Enantioseparácia Derivátov Propranololu

Propranolol je jedným z prvých pripravených a v klinickej praxi používaných beta-adrenolytík. V tejto práci boli pripravené nové deriváty propranololu s cyklohexylamino a pyrolidín-1-ylom v hydrofilnej časti molekuly. HPLC-enantioseparácia propranololu ako štandardu a pripravených deriváTov bola uskutočnená na kolóne CHIRALPAC AD s chirálnou fázou amylóza tris (3,5-dimetylfenylkarbamát). Stereoselektívnou syntézou bol pripravený pomocou Jacobsenovho katalyzátora (R)-enantiomér propranololu.

Keywords: propranolol; β-blockers; enantioseparation; HPLC; Chiralpak AD CSP

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About the article


Published Online: 2012-08-13

Published in Print: 2012-01-01


Citation Information: Acta Facultatis Pharmaceuticae Universitatis Comenianae, ISSN (Print) 0301-2298, DOI: https://doi.org/10.2478/v10219-012-0012-x.

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