Jump to ContentJump to Main Navigation
Show Summary Details
More options …

European Pharmaceutical Journal

Acta Facultatis Pharmaceuticae Universitatis Comenianae (formerly)

2 Issues per year


CiteScore 2016: 0.28

SCImago Journal Rank (SJR) 2015: 0.195
Source Normalized Impact per Paper (SNIP) 2015: 0.202

Open Access
Online
ISSN
2453-6725
See all formats and pricing
More options …

Comparison of classic and derivative UV spectrophotometric methods for determination of dextromethorphani hydrobromidum

J. Drozd
Published Online: 2012-08-13 | DOI: https://doi.org/10.2478/v10219-012-0014-8

Comparison of classic and derivative UV spectrophotometric methods for determination of dextromethorphani hydrobromidum

A method for the fast determination of dextromethorphani hydrobromidum in pharmaceutical preparations by classic spectrophotometry - zero and first-, second- and third-order derivative spectrophotometry, using "peak - peak" (P - P) and "peak - zero" (P - O) measurements has been performed. The calibration curves are linear within the concentration range of 1.0 - 25.0 μg ml-1 for dextromethorphani hydrobromidum. The procedure is simple, rapid and the results are reliable.

Keywords: Dextromethorphani hydrobromidum; classic spectrophotometry; derivative spectrophotometry

  • Brenner GM, Stevens CW. Pharmacology, Saunders; 2 ed., 2006.Google Scholar

  • Brunton L, Lazo J, Parker K. Goodman & Gilman's The Pharmacological Basis of Therapeutics, McGraw-Hill Professional; 11 ed., 2005.Google Scholar

  • Galli V, Barbas C. High-performance liquid chromatographic analysis of dextromethorphan, guaifenesin and benzoate in a cough syrup for stability testing. J Chromatogr. 2004;1048:207-211.Google Scholar

  • Lin SY, Chen CH, Ho HO, Chen HH, Sheu MT. Simultaneous analysis of dextromethorphan and its three metabolites in human plasma using an improved HPLC method with fluorometric detection. J Chromatogr. 2007;859:141-146.Web of ScienceGoogle Scholar

  • Louhaichi MR, Jebali S, Loueslati MH, Monser L. Simultaneous determination of dextromethorphan hydrobromide, pyrilamine maleate and sodium benzoate in cough cold syrup by LC. Chromatographia. 2009;69:421-427.Google Scholar

  • Louhaichi MR, Jebali S, Loueslati MH, Adhoum N, Monser L. Simultaneous determination of pseudoephedrine, pheniramine, guaifenesin, pyrilamine, chlorpheniramine and dextromethorphan in cough and cold medicines by high performance liquid chromatography. Talanta. 2009;78:991-997.Web of ScienceGoogle Scholar

  • Santagati NA, Gotti R, Ronsisvalle G. Simultaneous determination of phenytoin and dextromethorphan in urine by solid-phase extraction and HPLC-DAD. Journal of Separation Science. 2005;28:1157-1162.Google Scholar

  • Lou H, Yuan H, Ruan Z, Jiang B. Simultaneous determination of paracetamol, pseudoephedrine, dextrophan and chlorpheniramine in human plasma by liquid chromatography-tandem mass spectrometry. J Chromatogr. 2010;878:682-688.Google Scholar

  • Zhang W, Han F, Guo P, Zhao H, Lin Z, Huang MQ, Bertelsen K, Weng N. Simultaneous determination of tolbutamide, omeprazole, midazolam and dextromethorphan in human plasma by LC-MS/MS-A high throughput approach to evaluate drug-drug interactions. J Chromatogr. 2010;878:1169-1177.Google Scholar

  • Bagheri H, Es-haghi A, Rouini MR. Sol-gel-based solid-phase microextraction and gas chromatography-mass spectrometry determination of dextromethorphan and dextrorphan in human plasma. J Chromatogr. 2005;818:159-167.Google Scholar

  • Dong Y, Chen X, Chen Y, Chen X, Hu Z. Separation and determination of pseudoephedrine, dextromethorphan, diphenhydramine and chlorpheniramine in cold medicines by nonaqueous capillary electrophoresis. J Pharm Biomed Anal. 2005;39:285-289.Google Scholar

  • Yang XJ, Li OL, Chen ZG, Liu C, Lan Y, Zhao S. Determination of pseudoephedrine hydrochloride and dextromethorphan hydrobromide in cold tablet by micro-fluidic chip. Fenxi Huaxue. 2008;36:673-677.Google Scholar

  • Heli H, Majdi S, Jabbari A, Sattarahmady N, Moosavi-Movahedi AA. Electrooxidation of dextromethorphan on a carbon nanotube-carbon microparticle-ionic liquid composite: applied to determination in pharmaceutical forms. J Solid State Electrochem. 2010;14:1515-1520.Web of ScienceGoogle Scholar

  • Khaled E, Hassan HNA, Mohamed GG, Seleim AA. Carbon paste and PVC electrodes for the flow injection potentiometric determination of dextromethorphan. Talanta. 2010;81:510-515.Google Scholar

  • El-Naby EH. Polymeric membrane sensors for the selective determination of dextromethorphan in pharmaceutical preparations. Anal Sci. 2008;24:1409-1414.Web of ScienceGoogle Scholar

  • Sánchez RF, Bosch OC. Recent development in derivative ultraviolet/visible absorption spectrophotometry: 2004-2008: a review. Anal Chim Acta. 2009;635:22-44.Web of ScienceGoogle Scholar

About the article


Published Online: 2012-08-13

Published in Print: 2012-01-01


Citation Information: Acta Facultatis Pharmaceuticae Universitatis Comenianae, ISSN (Print) 0301-2298, DOI: https://doi.org/10.2478/v10219-012-0014-8.

Export Citation

This content is open access.

Comments (0)

Please log in or register to comment.
Log in