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Archives of Industrial Hygiene and Toxicology

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Volume 62, Issue 1


Cadmium Toxicity Revisited: Focus on Oxidative Stress Induction and Interactions with Zinc and Magnesium

Vesna Matović
  • Department of Toxicology "Akademik Danilo Soldatović", Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Aleksandra Buha
  • Department of Toxicology "Akademik Danilo Soldatović", Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Zorica Bulat
  • Department of Toxicology "Akademik Danilo Soldatović", Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Danijela Đukić-Ćosić
  • Department of Toxicology "Akademik Danilo Soldatović", Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2011-03-21 | DOI: https://doi.org/10.2478/10004-1254-62-2011-2075

Cadmium Toxicity Revisited: Focus on Oxidative Stress Induction and Interactions with Zinc and Magnesium

Discovered in late 1817, cadmium is currently one of the most important occupational and environmental pollutants. It is associated with renal, neurological, skeletal and other toxic effects, including reproductive toxicity, genotoxicity, and carcinogenicity. There is still much to find out about its mechanisms of action, biomarkers of critical effects, and ways to reduce health risks. At present, there is no clinically efficient agent to treat cadmium poisoning due to predominantly intracellular location of cadmium ions. This article gives a brief review of cadmium-induced oxidative stress and its interactions with essential elements zinc and magnesium as relevant mechanisms of cadmium toxicity. It draws on available literature data and our own results, which indicate that dietary supplementation of either essential element has beneficial effect under condition of cadmium exposure. We have also tackled the reasons why magnesium addition prevails over zinc and discussed the protective role of magnesium during cadmium exposure. These findings could help to solve the problem of prophylaxis and therapy of increased cadmium body burden.

Još o toksičnosti kadmija - s posebnim osvrtom na nastanak oksidacijskoga stresa i na interakcije s cinkom i magnezijem

Iako je otkriven tek 1817. godine, kadmij je trenutačno jedan od najvažnijih onečišćivača životne i radne sredine. Štetno djeluje na bubrege, živčani sustav, kosti, reproduktivni sistem, a ima i genotoksične i karcinogene efekte. Nužna su dalja istraživanja vezana za mehanizme njegove toksičnosti, biomarkere efekata, kao i načine smanjenja rizika za zdravlje. Osim toga, do danas nije otkriven agens efikasan u terapiji trovanja kadmijem s obzirom na to da je kadmij intracelularni kation. U ovom radu dan je sažet pregled važnih mehanizama toksičnosti kadmija, kao što su nastanak oksidativnog stresa i interakcije s esencijalnim elementima, cinkom i magnezijem, na osnovi dostupnih literaturnih podataka, kao i naših ispitivanja koja upućuju na to da povećani unos navedenih esencijalnih elemenata pokazuje pozitivne efekte pri ekspoziciji kadmiju. Obrazložena je prednost suplementacije magnezijem pred suplementacijom cinkom i razmatrana preventivna uloga magnezija pri intoksikaciji kadmijem. Ovi su rezultati doprinos rješavanju problema profilakse i terapije trovanja kadmijem.

Keywords: carcinogenicity; chelation therapy; dietary supplementation; essential elements

Keywords: esencijalni elementi; karcinogenost; kelatna terapija; suplementacija

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About the article

Published Online: 2011-03-21

Published in Print: 2011-03-01

Citation Information: Archives of Industrial Hygiene and Toxicology, Volume 62, Issue 1, Pages 65–76, ISSN (Print) 0004-1254, DOI: https://doi.org/10.2478/10004-1254-62-2011-2075.

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Stefania Pacini, Maria G. Fiore, Stefano Magherini, Gabriele Morucci, Jacopo J.V. Branca, Massimo Gulisano, and Marco Ruggiero
Medical Hypotheses, 2012, Volume 79, Number 3, Page 403
Tanja Živković, Blanka Tariba, and Alica Pizent
J. Anal. At. Spectrom., 2014, Volume 29, Number 11, Page 2114
Yolande Asara, Juan Marchal, Esther Carrasco, Houria Boulaiz, Giuliana Solinas, Pasquale Bandiera, Maria Garcia, Cristiano Farace, Andrea Montella, and Roberto Madeddu
International Journal of Molecular Sciences, 2013, Volume 14, Number 8, Page 16600
Kee-Yeon Kum, Qiang Zhu, Kamran Safavi, Yu Gu, Kwang-Shik Bae, and Seok Woo Chang
Australian Endodontic Journal, 2013, Volume 39, Number 3, Page 126
Aleksandra Buha, Biljana Antonijević, Zorica Bulat, Vesna Jaćević, Vesna Milovanović, and Vesna Matović
Toxicology Letters, 2013, Volume 221, Number 2, Page 83
Robin A. Bernhoft
The Scientific World Journal, 2013, Volume 2013, Page 1
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Journal of Applied Toxicology, 2014, Volume 34, Number 2, Page 205
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Chemical Reviews, 2012, Volume 112, Number 10, Page 5193
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The Scientific World Journal, 2012, Volume 2012, Page 1
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The Journal of Toxicological Sciences, 2012, Volume 37, Number 1, Page 191

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