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Acta Medica Bulgarica

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0324-1750
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Cardiac Glycoside Plants Self-Poisoning

J. Radenkova-Saeva / P. Atanasov
Published Online: 2014-11-05 | DOI: https://doi.org/10.2478/amb-2014-0013

Summary

Cardiac glycosides are found in a diverse group of plants including Digitalis purpurea and Digitalis lanata (foxgloves), Nerium oleander, Convallaria majalis (lily of the valley), Strophanthus gratus, etc. Nerium Oleander is an indoor and ornamental plant of an evergreen shrub. It’s widespread in countries with a Mediterranean climate. Oleander is one of the most poisonous plants known to humans. All parts of the nerium oleander are poisonous, primarily due to the contained cardiac glycosides - oleandrin, nerin, digitoxigenin, and olinerin of which oleandrin is the principal toxin. The bark contains the toxic substances of rosagenin which causes strychnine-like effects. Signs of poisoning appear a few hours after the adoption of the parts of the plant. Two cases of Nerium Oleander poisoning were presented. Clinical picture included gastrointestinal, cardiovascular and central nervous system effects. The clinical symptoms were characterized by nausea, vomiting, salivation, colic, diarrhoea, ventricular tachycardia, dysrhythmia, heart block, ataxia, drowsiness, muscular tremor. Treatment included administration of activated charcoal, symptomatic and supportive care.

Keywords : toxic plants; oleander; poisoning; glycosides; oleandrin

References

  • 1. Bessen , H. A. Therapeutic and toxic effects of digitalis: William Withering, 1785. - J. Emerg. Med., 4, 1986, № 3, 243.Google Scholar

  • 2. Bourgeois , B., P. Incagnoli, J. Hanna etV. Tirard. Traitement par anticorps antidigitalique d’une intoxication volontaire par laurier rose. - Annales Françaises d’Anesthésie et de Réanimation, 24, 2005, № 6, 640-642.Google Scholar

  • 3. Camphausen , C., N. A. Haas et A. C. Mattke. Successful treatment of oleander intoxication (cardiac glycosides) with digoxin-specifi c Fab antibody fragments in a 7-year-old child. - Zeitschrift für Kardiologie, 94, 2005, № 12, 817-823.Google Scholar

  • 4. Graeme , K. Toxic plant ingestions. In: Auerbach PS, ed. Wilderness Medicine, Chapter 58, 5th Ed. Philadelphia, Pa: Mosby Elsevier, 2007.Google Scholar

  • 5. Hostetler, M. et S. Schreiber. Poisonous plants. In: Tintinalli JE, Kelen GD, Stapczynski JS, Ma OJ, Cline DM, eds. Emergency Medicine: A Comprehensive Study Guide. Chapter 205, 6th ed. New York, NY: McGraw-Hill, 2004.Google Scholar

  • 6. LeCouteur, D. G. et A. A. Fisher. Chronic and criminal administration of Nerium oleander. - J. Toxicol. Clin. Toxicol., 40, 2002, № 4, 523-524.Google Scholar

  • 7. Sharma , P. et al. Chemical Constituents of Plants from the Genus Nerium. - Chemistry & Biodiversity, 7, 2010, № 5, 1198-1207.PubMedGoogle Scholar

  • 8. Langford S. D. et P. J. Boor. Oleander toxicity: an examination of human and animal toxic exposures. - Toxicology, 109, 1996, № 1, 1-13.PubMedGoogle Scholar

  • 9. Senthilkumaran , S. et al. (2011). Electrocardiographic changes during inhalational oleander toxicity. - J. Electrocardiol., 44, 2011, № 4, 470-472.CrossrefWeb of ScienceGoogle Scholar

  • 10. Wasfi , I. et al. (2008). A fatal case of oleandrin poisoning. - Forensic Science Int., 179, 2008, № 2-3, e31-36. Web of ScienceGoogle Scholar

About the article

Published Online: 2014-11-05

Published in Print: 2014-06-01


Citation Information: Acta Medica Bulgarica, ISSN (Online) 0324-1750, DOI: https://doi.org/10.2478/amb-2014-0013.

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© 2014. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

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