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Acta Medica Marisiensis

The Journal of The University of Medicine and Pharmacy of Targu-Mures

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Internal Structure Quality Control of Solid Pharmaceuticals. A Comparative Study

Silvia Imre / Timea Haidu / Oana Ponta
  • “Babeş-Bolyai” University, Faculty of Physics & Interdisciplinary Research Institute on Bio-Nano-Sciences, Cluj-Napoca, Romania
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Szende Vancea / Camil-Eugen Vari / Amelia Tero-Vescan
Published Online: 2016-02-09 | DOI: https://doi.org/10.1515/amma-2015-0104


Objective: The aim of the study was a comparative investigation by spectral and thermal analysis in order to asses a number of characteristics of different varieties ofrawmaterials of ursodeoxycholic acid and ibuprofen. The different dissolution behavior of two ursodeoxycholic acid pharmaceutical product by crystallinity pattern was investigated. Methods: Raw materials of ursodeoxycholic acid and ibuprofen were used. IR spectroscopy, differential scanning calorimetry and X-Ray Diffraction Analysis were applied. Results: The results show no crystallinitydifferences for different batches of the tested drugs. No solid solid transition was proved during sample preparation for transmission IR analysis. Conclusions: A combination of two more affordabletests by IR spectrometry and differential scanning calorimetry lead to the same results as X-Ray diffraction analysis for crystallinity similarity assessment of the studied substances. The dissolution differences of test drugs were not related to the polymorphism of the raw materials.

Keywords: IR spectroscopy; DSC; X-Ray Diffraction Analysis (XRD); ibuprofen; ursodeoxycholic acid


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About the article

Received: 2015-08-12

Accepted: 2015-09-05

Published Online: 2016-02-09

Published in Print: 2016-03-01

Citation Information: Acta Medica Marisiensis, Volume 62, Issue 1, Pages 95–100, ISSN (Online) 2247-6113, DOI: https://doi.org/10.1515/amma-2015-0104.

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© by Silvia Imre. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License. BY-NC-ND 4.0

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